AB136880

Anti-Plexin B1 antibody

Name: Anti-Plexin B1 antibody (ab136880) | Abcam
Brand: Abcam Limited
SKU: AB136880

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(1 Publication)

Rabbit Polyclonal Plexin B1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.

View Alternative Names

KIAA0407, PLXN5, SEP, PLXNB1, Plexin-B1, Semaphorin receptor SEP

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plexin B1 antibody (AB136880)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plexin B1 antibody (AB136880)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human liver tissue labelling Plexin B1 with ab136880 at 5µg/ml.

Unknown

Western blot - Anti-Plexin B1 antibody (AB136880)

The higher band represents Plexin B1 precursor and the lower band Plexin B1 cleavage product.

All lanes:

Western blot - Anti-Plexin B1 antibody (ab136880) at 1/300 dilution

All lanes:

HeLa cell membrane extract

Predicted band size: 232 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

Preservative: 0.05% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Plexin-B1 also known as PLXNB1 is a transmembrane receptor with a molecular weight of approximately 230 kDa. It plays an important role in cellular communication by binding semaphorin ligands influencing cell adhesion and migration. Plexin-B1 is widely expressed in various tissues including the nervous system where it impacts neural development. By mediating axonal guidance and cytoskeletal dynamics Plexin-B1 contributes to the signaling processes fundamental to neuronal pathfinding and connection establishment.

Biological function summary

Plexin-B1 associates with multiple proteins to form signaling complexes that regulate cellular processes. Its interaction with small GTPases like RhoA influences actin cytoskeleton organization impacting cell morphology and motility. Plexin-B1 also plays a role in epithelial cell function and survival acting through pathways that restrict or allow cellular proliferation. These interactions facilitate diverse physiological responses including changes in cell shape cellular migration and apoptosis.

Pathways

Plexin-B1 is involved in signaling cascades such as the semaphorin-plexin pathway and the RhoA/Rho kinase (ROCK) pathway. Through these pathways Plexin-B1 interacts with the receptor tyrosine kinase MET influencing cell motility and invasive growth responses. Plexin-B1 links to Rho GTPases modulating actin dynamics and contributing to cell shape alterations and motility in these pathways. These interactions exemplify Plexin-B1's integration within complex signaling networks that control developmental and cellular processes.

Plexin-B1 shows associations with cancer progression and neural abnormalities. Altered Plexin-B1 expression or function relates to prostate cancer where it participates with MET in promoting epithelial-mesenchymal transition and tumor metastasis. In the neurological domain Plexin-B1 dysfunction connects with schizophrenia by potentially affecting neural connectivity and synaptic integrity. These insights underline Plexin-B1's involvement with critical proteins in pathological contexts influencing the progression and severity of these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Receptor for SEMA4D (PubMed : 19843518, PubMed : 20877282, PubMed : 21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed : 12196628, PubMed : 15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed : 12198496).

See full target information PLXNB1

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Diabetes, metabolic syndrome and obesity : targets and therapy 14:3461-3470 PubMed34366677

2021

Osteoclasts May Affect Glucose Uptake-Related Insulin Resistance by Secreting Resistin.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangqi Li,Fei Sun,Jiancan Lu,Jichen Zhang,Jingnan Wang,Hongling Zhu,Mingjun Gu,Junhua Ma

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Plexin B1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plexin B1 antibody (AB136880)

Western blot - Anti-Plexin B1 antibody (AB136880)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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