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AB204172

Anti-Plexin-B3 antibody

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(1 Publication)

Rabbit Polyclonal Plexin-B3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PLXNB3 aa 1000 to C-terminus.

View Alternative Names

KIAA1206, PLXN6, PLXNB3, Plexin-B3

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plexin-B3 antibody (AB204172)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plexin-B3 antibody (AB204172)

Immunohistochemical analysis of paraffin-embedded Human cerebellum tissue labeling Plexin-B3 with ab204172 at 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PLXNB3 aa 1000 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9ULL4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Plexin-B3 also known as PLXNB3 is a membrane protein with an estimated mass of approximately 215 kDa. It functions as a receptor for semaphorins particularly Sema5A in cell signaling processes. Plexin-B3 influences actin cytoskeleton rearrangement by interacting with the Rho GTPase family members. It is expressed in several tissues including the brain kidney and heart which suggests its diverse roles in different cellular contexts.
Biological function summary

Plexin-B3 modulates cellular processes such as growth adhesion migration and axon guidance. It forms complexes with other proteins such as Met and ErbB2 indicating its involvement in diverse signaling pathways. This protein plays an important role in the nervous system influencing neural circuit formation and neuronal connectivity. Its function in cell migration and adhesion also implicates it in cancer metastasis-related activities in various tumors.

Pathways

Plexin-B3 participates in the semaphorin signaling pathway which is important for guiding neuronal axons and other migratory cells. It engages with proteins like RhoA and Rac1 to transmit downstream signals that affect cytoskeletal dynamics. The role of Plexin-B3 in these pathways highlights its importance in maintaining cellular architecture and regulation of cell movement.

Plexin-B3 has connections to certain cancers including prostate and brain cancer. Its interaction with Met a receptor tyrosine kinase links it to oncogenic processes including enhanced cellular proliferation and migration. Furthermore studies suggest a potential involvement in neurological disorders such as autism given its critical role in neural circuit formation and guidance although this requires further investigation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.
See full target information PLXNB3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 15:878 PubMed39632825

2024

Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance.

Applications

Unspecified application

Species

Unspecified reactive species

A Esposito,A Agostini,G Quero,G Piro,L Priori,A Caggiano,G Scaglione,A Battaglia,M A Calegari,L Salvatore,M Bensi,M G Maratta,A Ceccarelli,G Trovato,G Genovese,E Gurreri,S Ascrizzi,M Martini,C Fiorillo,A Fattorossi,F De Sanctis,S Ugel,V Corbo,S Alfieri,G Tortora,C Carbone
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Product promise

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