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AB128698

Anti-PLOD3 antibody

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(8 Publications)

Rabbit Polyclonal PLOD3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PLOD3 aa 250-550.

View Alternative Names

Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3, PLOD3

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLOD3 antibody (AB128698)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLOD3 antibody (AB128698)

ab128698, at a dilution of 1/100, staining PLOD3 in Formalin-fixed, Paraffin-embedded human fetal small intestine by Immunohistochemistry

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PLOD3 aa 250-550. The exact immunogen used to generate this antibody is proprietary information.

O60568

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Lyophilized
Reconstitution
Reconstitute in 200 µL of water
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.02% Sodium azide Constituents: 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen (PubMed : 11956192, PubMed : 12475640, PubMed : 18298658, PubMed : 18834968, PubMed : 30089812). Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed : 11956192, PubMed : 12475640, PubMed : 18298658, PubMed : 18834968, PubMed : 30089812, PubMed : 9582318, PubMed : 9724729). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (PubMed : 12475640, PubMed : 18298658, PubMed : 18834968, PubMed : 30089812). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed : 10934207, PubMed : 11896059, PubMed : 11956192, PubMed : 12475640, PubMed : 18298658, PubMed : 18834968, PubMed : 30089812). Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like domain, giving rise to hydroxylysine and 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed : 25419660). Essential for normal biosynthesis and secretion of type IV collagens (Probable) (PubMed : 18834968). Essential for normal formation of basement membranes (By similarity).
See full target information PLOD3
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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Biomacromolecules 25:6485-6502 PubMed39214607

2024

Harnessing the Biomimetic Effect of Macromolecular Crowding in the Cell-Derived Model of Clubfoot Fibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Martina Doubková,Jarmila Knitlová,David Vondrášek,Adam Eckhardt,Tomáš Novotný,Martin Ošt'ádal,Elena Filová,Lucie Bačáková

Laboratory investigation; a journal of technical methods and pathology 101:564-569 PubMed36775379

2023

PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Guo,Chao Gu,Bin Li,Congjian Xu

Frontiers in immunology 12:722807 PubMed34646265

2021

Integrated Profiling Identifies as a Potential Prognostic and Immunotherapy Relevant Biomarker in Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Junhong Shi,Meiyu Bao,Weifeng Wang,Xuan Wu,Yueying Li,Changdong Zhao,Weiwei Liu

Laboratory investigation; a journal of technical m : PubMed33483598

2021

PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Guo,Chao Gu,Bin Li,Congjian Xu

Molecular and cellular probes 53:101608 PubMed32585183

2020

Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Da Xie,Jin Li,Shufei Wei,Pan Qi,Hongxia Ji,Jianzhi Su,Nan Du,Xiaoyu Zhang

Archives of medical science : AMS 16:436-445 PubMed32190155

2019

Lysyl hydroxylase 3 increases collagen deposition and promotes pulmonary fibrosis by activating TGFβ1/Smad3 and Wnt/β-catenin pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Songjun Shao,Haiyan Fang,Lindi Duan,Xianwei Ye,Shanshan Rao,Jin Han,Yumei Li,Guohang Yuan,Weijia Liu,Xiangyan Zhang

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 39:547-561 PubMed30516406

2018

Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Hao Li,Haochen Xu,Hongyan Wen,Tianlong Liu,Yingying Sun,Ning Xiao,Congxia Bai,Jing Ge,Xuliang Wang,Li Song,Yan Song,Yinhui Zhang,Jingzhou Chen

Medical science monitor : international medical jo 24:8592-8601 PubMed30481795

2018

Lysyl Hydroxylase Inhibition by Minoxidil Blocks Collagen Deposition and Prevents Pulmonary Fibrosis via TGF-β₁/Smad3 Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Songjun Shao,Xiangning Zhang,Lingdi Duan,Haiyan Fang,Shanshan Rao,Weijia Liu,Bing Guo,Xiangyan Zhang
View all publications
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Product promise

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