AB228907

Anti-PLSCR4 antibody

Name: Anti-PLSCR4 antibody (ab228907) | Abcam
Brand: Abcam Limited
SKU: AB228907
Price: 525 USD
Availability: InStock

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal PLSCR4 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PLSCR4.

View Alternative Names

GIG43, PLSCR4, Phospholipid scramblase 4, PL scramblase 4, Ca(2+)-dependent phospholipid scramblase 4, Cell growth-inhibiting gene 43 protein, TRA1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLSCR4 antibody (AB228907)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLSCR4 antibody (AB228907)

Paraffin-embedded mouse intestine tissue stained for PLSCR4 protein using ab228907 at 1/1000 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-PLSCR4 antibody (AB228907)

10% SDS-PAGE gel.

All lanes:

Western blot - Anti-PLSCR4 antibody (ab228907) at 1/1000 dilution

Lane 1:

HEK-293T (Human epithelial cell line from embryonic kidney) whole cell extracts at 30 µg

Lane 2:

A431 (human epidermoid carcinoma cell line) whole cell extracts at 30 µg

Lane 3:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell extracts at 30 µg

Lane 4:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell extracts at 30 µg

Predicted band size: 37 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PLSCR4. The exact immunogen used to generate this antibody is proprietary information.

Q9NRQ2

style

left-column

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PLSCR4 also known as Phospholipid Scramblase 4 is a member of the scramblase family and involves in phospholipid translocation across membranes. This protein has a molecular mass of approximately 34 kDa. Expressed in various tissues PLSCR4 shows significant presence in hematopoietic cells and brain tissues. Its distribution suggests diverse functional roles across different physiological systems in the body.

Biological function summary

PLSCR4 functions in modulating cellular membranes' lipid asymmetry which is important for maintaining cell membrane fluidity and other processes. It does not generally form part of a larger complex acting more independently in its role compared to some members of the scramblase family. Through its activity PLSCR4 also has a potential role in signal transduction and apoptosis regulation where lipid dynamics are essential.

Pathways

PLSCR4 mainly connects to apoptotic signaling and immune response pathways. It influences events where membrane lipid composition is important for signaling transduction. Proteins such as caspases may interact or function in parallel as they participate with scramblase family members during apoptosis. PLSCR4's involvement in these pathways highlights its importance in cell death regulation and immune system functionality.

PLSCR4 may be involved in cancer and neurological disorders where dysregulated apoptosis and signaling can contribute to disease progression. Altered expression or function of PLSCR4 linked with proteins like Bcl-2 family members might influence cancer cell survival and resistance to apoptosis. In neurological contexts its expression levels and activity may affect neurodegenerative conditions through pathways involving cell survival and signaling maintenance.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.

See full target information PLSCR4

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular and clinical oncology 23:72 PubMed40599718

2025

Nuclear factor IA-mediated transcriptional regulation of crystallin αB inhibits hepatocellular carcinoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Jin,Pingping Hu,Yihe Dai,Wenchao Gu,Jiang Han,Haihan Song

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PLSCR4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLSCR4 antibody (AB228907)

Western blot - Anti-PLSCR4 antibody (AB228907)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise