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AB233005

Anti-PLSCR4 antibody

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(3 Publications )

Rabbit Polyclonal PLSCR4 antibody. Suitable for WB, IHC-P and reacts with Mouse, Pig, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PLSCR4 aa 1-350.

View Alternative Names

GIG43, PLSCR4, Phospholipid scramblase 4, PL scramblase 4, Ca(2+)-dependent phospholipid scramblase 4, Cell growth-inhibiting gene 43 protein, TRA1

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLSCR4 antibody (AB233005)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PLSCR4 antibody (AB233005)

Formalin-fixed, paraffin-embedded human kidney tissue stained for PLSCR4 using ab233005 at 20 μg/mL in immunohistochemical analysis. DAB staining.

Western blot - Anti-PLSCR4 antibody (AB233005)
  • WB

Supplier Data

Western blot - Anti-PLSCR4 antibody (AB233005)

All lanes:

Western blot - Anti-PLSCR4 antibody (ab233005) at 3 µg/mL

All lanes:

Mouse stomach lysate

Predicted band size: 37 kDa

false

Western blot - Anti-PLSCR4 antibody (AB233005)
  • WB

Supplier Data

Western blot - Anti-PLSCR4 antibody (AB233005)

All lanes:

Western blot - Anti-PLSCR4 antibody (ab233005) at 2 µg/mL

All lanes:

recombinant human PLSCR4 protein

Predicted band size: 37 kDa

false

Western blot - Anti-PLSCR4 antibody (AB233005)
  • WB

Supplier Data

Western blot - Anti-PLSCR4 antibody (AB233005)

All lanes:

Western blot - Anti-PLSCR4 antibody (ab233005) at 3 µg/mL

All lanes:

Pig lung lysate

Predicted band size: 37 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human, Pig

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PLSCR4 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.

Q9NRQ2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PLSCR4 also known as Phospholipid Scramblase 4 is a member of the scramblase family and involves in phospholipid translocation across membranes. This protein has a molecular mass of approximately 34 kDa. Expressed in various tissues PLSCR4 shows significant presence in hematopoietic cells and brain tissues. Its distribution suggests diverse functional roles across different physiological systems in the body.
Biological function summary

PLSCR4 functions in modulating cellular membranes' lipid asymmetry which is important for maintaining cell membrane fluidity and other processes. It does not generally form part of a larger complex acting more independently in its role compared to some members of the scramblase family. Through its activity PLSCR4 also has a potential role in signal transduction and apoptosis regulation where lipid dynamics are essential.

Pathways

PLSCR4 mainly connects to apoptotic signaling and immune response pathways. It influences events where membrane lipid composition is important for signaling transduction. Proteins such as caspases may interact or function in parallel as they participate with scramblase family members during apoptosis. PLSCR4's involvement in these pathways highlights its importance in cell death regulation and immune system functionality.

PLSCR4 may be involved in cancer and neurological disorders where dysregulated apoptosis and signaling can contribute to disease progression. Altered expression or function of PLSCR4 linked with proteins like Bcl-2 family members might influence cancer cell survival and resistance to apoptosis. In neurological contexts its expression levels and activity may affect neurodegenerative conditions through pathways involving cell survival and signaling maintenance.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
See full target information PLSCR4
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:4124 PubMed40319020

2025

Non-canonical Wnt signaling promotes epithelial fluidization in the repairing airway.

Applications

Unspecified application

Species

Unspecified reactive species

Daniel Jun-Kit Hu,Xiaoyu Tracy Cai,Jesse Simons,Jina Yun,Justin Elstrott,Heinrich Jasper

Biological & pharmaceutical bulletin 47:1136-1143 PubMed38866522

2024

Phospholipid Scramblase 1 Localizes Proximal to Sphingomyelin Synthase Isoforms but Is Not Involved in Sphingomyelin Synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yasuhiro Hayashi,Takehiro Suzuki,Naoto Horioka,Naoshi Dohmae,Takashi Tanikawa

International journal of molecular sciences 23: PubMed36077184

2022

Phospholipid Scramblase 4 (PLSCR4) Regulates Adipocyte Differentiation via PIP3-Mediated AKT Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Lisa A G Barth,Michèle Nebe,Hermann Kalwa,Akhil Velluva,Stephanie Kehr,Florentien Kolbig,Patricia Prabutzki,Wieland Kiess,Diana Le Duc,Antje Garten,Anna S Kirstein
View all publications
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Product promise

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