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AB67226

Anti-Plxdc2 antibody

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(1 Publication)

Rabbit Polyclonal Plxdc2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PLXDC2.

View Alternative Names

TEM7R, UNQ2514/PRO6003, PLXDC2, Plexin domain-containing protein 2, Tumor endothelial marker 7-related protein

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plxdc2 antibody (AB67226)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Plxdc2 antibody (AB67226)

This image shows human brain tissue stained with ab67226 at 2.5μg/ml.

Immunocytochemistry/ Immunofluorescence - Anti-Plxdc2 antibody (AB67226)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Plxdc2 antibody (AB67226)

Immunofluorescence of Plxdc2 in Human Brain cells using ab67226 at 50 ug/ml.

Western blot - Anti-Plxdc2 antibody (AB67226)
  • WB

Unknown

Western blot - Anti-Plxdc2 antibody (AB67226)

Lane 1:

Western blot - Anti-Plxdc2 antibody (ab67226) at 0.5 µg/mL

Lane 2:

Western blot - Anti-Plxdc2 antibody (ab67226) at 1 µg/mL

All lanes:

human colon tissue lysate at 15 µg

Predicted band size: 60 kDa

Observed band size: 60 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human PLXDC2. The exact immunogen used to generate this antibody is proprietary information.

Q6UX71

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Plexin domain containing 2 (PLXDC2) also known as tumor endothelial marker 7 (TEM7) is a protein involved in cellular signaling. It has a molecular mass of approximately 65 kDa. PLXDC2 is significantly expressed in endothelial cells particularly within the vasculature where it may play a role in cell adhesion and migration processes. The expression of PLXDC2 has been observed in various tissues with notable presence in the brain and liver suggesting its importance in multiple physiological contexts.
Biological function summary

PLXDC2 functions as part of the extracellular matrix (ECM) interaction network. It potentially contributes to angiogenesis and vascular remodeling by influencing endothelial cell behavior. While not a classic receptor PLXDC2 interacts with other ECM components and cell surface molecules to support cellular communication and interaction. These activities highlight its involvement in dynamic vascular processes and possibly in tissue homeostasis and repair mechanisms.

Pathways

PLXDC2 participates in pathways related to the regulation of angiogenesis and ECM remodeling. It shows connections to the vascular endothelial growth factor (VEGF) pathway which is integral to promoting new blood vessel formation. Additionally PLXDC2 is associated with integrins which facilitate ECM interactions and influence cell movement and signaling. This involvement indicates PLXDC2's contributory role in maintaining vascular integrity and supporting tissue regeneration.

PLXDC2's aberrant expression links to cancer progression and possibly metastasis. Its expression levels have shown correlation with tumors particularly in their angiogenic regions indicating a potential role in tumor growth and vascularization. PLXDC2 association with VEGF implicates it in oncological conditions including various types of cancer where angiogenesis is a critical factor. Understanding PLXDC2's role in these contexts can offer insights into new therapeutic strategies targeting tumor vasculature.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in tumor angiogenesis.
See full target information PLXDC2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular and cellular biology 30:4698-711 PubMed20679480

2010

Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Manuela Molzan,Benjamin Schumacher,Corinna Ottmann,Angela Baljuls,Lisa Polzien,Michael Weyand,Philipp Thiel,Rolf Rose,Micheline Rose,Philipp Kuhenne,Markus Kaiser,Ulf R Rapp,Jürgen Kuhlmann,Christian Ottmann
View all publications
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Product promise

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