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AB203249

Anti-PMP2 antibody

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(1 Publication)

Rabbit Polyclonal PMP2 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PMP2 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Myelin P2 protein, Peripheral myelin protein 2, PMP2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PMP2 antibody (AB203249)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PMP2 antibody (AB203249)

Immunohistochemical analysis of formalin-fixed paraffin-embedded rat brain tissue sections labeling PMP2 with ab203249 at a 1/200 dilution. The secondary antibody was a goat anti-rabbit IgG-Cy3 used at a 1/200 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PMP2 antibody (AB203249)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PMP2 antibody (AB203249)

Immunohistochemical analysis of formalin-fixed paraffin-embedded rat brain tissue sections labeling PMP2 with ab203249 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PMP2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P02689

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p>1/50-1/200 when using fluorescent detection methods.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The peripheral myelin protein 2 (PMP2) also known as FABP8 is a small protein with a mass of around 14 kDa. This target acts mechanically as a fatty acid-binding protein. It plays a significant function in the peripheral nervous system specifically in the myelin sheath of Schwann cells. The myelin sheath covers nerves and PMP2 helps stabilize its structure. This protein shows high expression in the sciatic nerve and other peripheral nerves indicating its importance in maintaining nerve functions.
Biological function summary

The peripheral myelin protein 2 aids in lipid transport within the myelin sheath helping in nerve conduction by maintaining the integrity of myelin membranes. This protein does not operate in isolation but participates as a part of the myelin molecular complex interacting with other myelin-related proteins. PMP2's ability to bind fatty acids supports the myelin sheath's plasticity and resilience ensuring efficient signal transmission across nerve cells.

Pathways

Several processes involve the peripheral myelin protein 2 especially lipid transport and metabolism pathways. In particular PMP2 functions in the PPAR signaling pathway which is important for lipid homeostasis and energy balance. Proteins such as PMP22 are closely associated with PMP2 since both have roles in maintaining the structural integrity and function of the myelin sheath despite being functionally distinct.

Malfunction or misregulation of peripheral myelin protein 2 can lead to peripheral neuropathies. Charcot-Marie-Tooth disease type 1A (CMT1A) specifically associates with PMP2 where duplications in the gene region disrupt normal myelin sheath function leading to decreased nerve signal transmission. In this disease PMP2 interacts with other proteins like PMP22 amplifying the pathogenic effects when its function is disrupted highlighting its relevance in therapeutic targets for demyelinating conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
See full target information PMP2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in medicine 8:675363 PubMed34084773

2021

Enhanced mPGES-1 Contributes to PD-Related Peritoneal Fibrosis via Activation of the NLRP3 Inflammasome.

Applications

Unspecified application

Species

Unspecified reactive species

Qimei Luo,Qinghua Hu,Qingkun Zheng,Lewei Gong,Lijuan Su,Baojun Ren,Yongle Ju,Zhanjun Jia,Xianrui Dou
View all publications
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Product promise

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