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AB150921

Anti-PNMA5 antibody

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(2 Publications)

Rabbit Polyclonal PNMA5 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PNMA5 aa 350 to C-terminus.

View Alternative Names

KIAA1934, PNMA5, Paraneoplastic antigen-like protein 5, Tumor antigen BJ-HCC-25

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PNMA5 antibody (AB150921)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PNMA5 antibody (AB150921)

Immunohistochemical analysis of paraffin-embedded Human testis tissue labeling PNMA5 with ab150921 at 1/200 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-PNMA5 antibody (AB150921)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PNMA5 antibody (AB150921)

Immunofluorescent staining of Human cell line U-251 MG shows positivity in centrosome. Recommended concentration of ab150921 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PNMA5 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96PV4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Recommend PFA Fixation and Triton X-100 treatment</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PNMA5 also known as Paraneoplastic Ma antigen family member 5 is a protein with a molecular mass of approximately 55 kDa. This protein localizes mainly in neuronal tissues and researchers have detected it particularly in brain regions. PNMA5 exhibits a typical structure shared with other members of the PNMA family which suggests a conserved function across this group of proteins. This structural resemblance indicates that PNMA5 likely plays a role in cellular processes important for neuronal activity.
Biological function summary

PNMA5 contributes to cellular mechanisms related to neuronal function and survival. While it is not known to form part of a defined protein complex PNMA5 interacts with other neuronal proteins to facilitate processes essential for maintaining neuronal integrity and health. The protein's function becomes valuable in understanding processes underlying cell survival and response to cellular stress.

Pathways

PNMA5 shows relevance within the neuronal signaling and cellular stress response pathways. These pathways ensure that neurons operate efficiently and adaptively especially under stress conditions. In relation to these pathways the BAX protein is an important associated element as both play roles in the regulation of apoptosis in neurons. The interaction with BAX highlights the function of PNMA5 in mediating cellular responses during critical periods of cellular stress.

PNMA5 has been associated with certain neurological conditions including paraneoplastic syndromes which involve immune-mediated neuronal damage. The dysfunction of PNMA5 in connection with other PNMA family members like PNMA1 may contribute to the pathogenesis of these disorders. Understanding the involvement of PNMA5 in these diseases might reveal new insights into their underlying mechanisms and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information PNMA5
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:2638 PubMed35551189

2022

MRNIP condensates promote DNA double-strand break sensing and end resection.

Applications

Unspecified application

Species

Unspecified reactive species

Yun-Long Wang,Wan-Wen Zhao,Shao-Mei Bai,Li-Li Feng,Shu-Ying Bie,Li Gong,Fang Wang,Ming-Biao Wei,Wei-Xing Feng,Xiao-Lin Pang,Cao-Litao Qin,Xin-Ke Yin,Ying-Nai Wang,Weihua Zhou,Daniel R Wahl,Quentin Liu,Ming Chen,Mien-Chie Hung,Xiang-Bo Wan

Frontiers in cell and developmental biology 9:678931 PubMed34136487

2021

PNMA5 Promotes Bone Metastasis of Non-small-Cell Lung Cancer as a Target of BMP2 Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Huang,Yaqiang Cao,Caihong Wang,Ruilong Lan,Bing Wu,Xianhe Xie,Jinsheng Hong,Lengxi Fu,Gui Wu
View all publications
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Product promise

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