Rabbit Polyclonal PNPLA4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PNPLA4 aa 1-250.
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
WB | IHC-P | |
---|---|---|
Human | Tested | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info - | Notes - |
Has abundant triacylglycerol lipase activity (PubMed:15364929, PubMed:16150821, PubMed:17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed:17603008). Additionally possesses acylglycerol transacylase and phospholipase A2 activities (PubMed:15364929, PubMed:17603008).
DXS1283E, GS2, PNPLA4, Patatin-like phospholipase domain-containing protein 4, Calcium-independent phospholipase A2-eta, Protein GS2, iPLA2-eta
Rabbit Polyclonal PNPLA4 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PNPLA4 aa 1-250.
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
PNPLA4 also known as patatin-like phospholipase domain-containing protein 4 or GS2 is a lipid-modifying enzyme with a molecular weight of approximately 53 kDa. It plays a role in lipid metabolism by catalyzing the hydrolysis of phospholipids to glycerolipids and free fatty acids. You can find PNPLA4 widely expressed in various tissues including the liver adipose tissue and skin. This enzyme contributes to maintaining lipid homeostasis and is part of a larger family of patatin-like phospholipases that show distinct functions in lipid metabolism.
PNPLA4 participates in lipid remodeling within cellular membranes and storage lipid pools. The protein facilitates the mobilization and alteration of lipid molecules a process important for normal cellular function and response to environmental changes. PNPLA4 may operate as a part of larger enzymatic complexes involved in lipid droplet formation and utilization. By impacting lipid dynamics PNPLA4 influences cellular energy regulation and membrane composition which is critical for various physiological processes such as energy storage and cell signaling.
The PNPLA4 protein is a component of the glycerolipid metabolism and fatty acid degradation pathways. It functions alongside proteins such as ATGL (adipose triglyceride lipase) and HSL (hormone-sensitive lipase) which also regulate lipid breakdown and mobilization. PNPLA4's enzymatic activity and interactions contribute to the regulation of energy balance fatty acid availability and lipid signaling affecting metabolic processes and overall cellular health.
PNPLA4 associates with disorders related to lipid metabolism such as metabolic syndrome and liver steatosis. Altered PNPLA4 function can disrupt lipid homeostasis leading to excessive lipid accumulation within tissues particularly the liver. This dysfunction often correlates with a cascade of metabolic disturbances. PNPLA4 also connects to APOE another lipid-related protein implicated in metabolic and cardiovascular diseases. Understanding PNPLA4’s role in these conditions could offer insights into potential therapeutic approaches to manage or alleviate related metabolic disorders.
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12% SDS PAGE
All lanes: Western blot - Anti-PNPLA4 antibody (ab125879) at 1/500 dilution
All lanes: H1299 whole cell lysate at 30 µg
Predicted band size: 26 kDa, 27 kDa
Immunohistochemical analysis of paraffin-embedded Hepatoma, using ab125879 antibody at 1:500 dilution
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