Anti-PNRC2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The PNRC2 protein also known as Proline-Rich Nuclear Receptor Coactivator 2 plays roles in the regulation of nuclear receptor activity. With an approximate mass of 15 kDa PNRC2 facilitates protein-protein interactions within the nucleus. This protein is expressed in various tissues indicating a widespread physiological influence. Researchers have identified it along with other proteins that contain proline-rich motifs across different cell types.

Biological function summary

PNRC2 interacts with nuclear receptors and transcriptional machinery to modulate gene expression. It acts as a coactivator meaning it enhances the activity of nuclear receptors though it does not bind to DNA directly. PNRC2 forms part of larger multi-protein complexes working in concert with transcription factors to regulate specific target genes. These interactions influence important biological processes including cell growth and apoptosis.

Pathways

PNRC2 impacts nuclear receptor signaling and gene transcription regulation. This protein involves itself in the steroid hormone receptor pathway and potentially the thyroid hormone receptor pathway. In these pathways PNRC2 interacts with proteins such as the Retinoid X Receptor (RXR) and the Estrogen Receptor (ER). These interactions allow PNRC2 to modulate cellular responses to hormones affecting processes such as cell proliferation and differentiation.

Associated diseases and disorders

PNRC2 has connections to hormone-related cancers and metabolic disorders. In breast cancer PNRC2 influences the activity of the Estrogen Receptor an important player in tumor growth and progression. PNRC2 also displays associations with proteins like the Androgen Receptor in the context of prostate cancer. Dysregulation of PNRC2 activity could contribute to abnormal cell proliferation highlighting its potential as a therapeutic target in these diseases.