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AB171934

Anti-POGZ antibody

3

(1 Review)

|

(5 Publications)

Rabbit Polyclonal POGZ antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human POGZ aa 1-600.

View Alternative Names

KIAA0461, SUHW5, ZNF280E, ZNF635, Nbla00003, POGZ, Pogo transposable element with ZNF domain, Suppressor of hairy wing homolog 5, Zinc finger protein 280E, Zinc finger protein 635

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-POGZ antibody (AB171934)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-POGZ antibody (AB171934)

Immunofluorescenct analysis of HeLa cells (chromosome spread preparations) labeling POGZ with ab171934 at 1/500 dilution and stained with Hoechst 33342.

Immunocytochemistry/ Immunofluorescence - Anti-POGZ antibody (AB171934)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-POGZ antibody (AB171934)

Immunofluorescent analysis of Paraformaldehyde-fixed HeLa cells labeling POGZ with ab171934 at 1/500 dilution and stained with Hoechst 33342.

Western blot - Anti-POGZ antibody (AB171934)
  • WB

Supplier Data

Western blot - Anti-POGZ antibody (AB171934)

All lanes:

Western blot - Anti-POGZ antibody (ab171934) at 1/1000 dilution

Lane 1:

Crude extract of HeLa cells transfected with control siRNA

Lane 2:

Crude extract of HeLa cells transfected with POGZ siRNA

Predicted band size: 155 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human POGZ aa 1-600. The exact immunogen used to generate this antibody is proprietary information.

Q7Z3K3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Purification notes
Sterilized by filtration through 0.22 µm membrane.
Storage buffer
pH: 6.5 - 8.5
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

POGZ also known as Pogo Transposable Element with ZNF Domain is a zinc finger protein with a molecular weight of approximately 155 kDa. Scientists have studied POGZ for its role in transcription regulation. This protein localizes primarily in the nucleus and is expressed in various human tissues with higher expression levels observed in the brain. POGZ interacts with chromatin and may play a role in the regulation of gene expression through chromatin remodeling.
Biological function summary

POGZ influences genetic expression by participating in the chromatin modification process. It acts as a member of the protein complex that includes histone modifiers modifying the chromatin landscape to allow or restrict access for transcription machinery. The protein impacts neuronal differentiation and brain development among other processes therefore bearing significance in neurodevelopmental biology. It partners with several key proteins to achieve its biological functions contributing to the regulation of genes required for proper cellular function.

Pathways

More than one biological pathway has involved POGZ. Notably it participates in the chromatin remodeling pathway important for modulating chromatin structure and gene accessibility. POGZ interacts with proteins such as CHD4 part of the NuRD complex within these pathways. These interactions facilitate access to DNA regulating the transcription of genes tied to cellular differentiation and proliferation.

Genetics has linked POGZ to neurodevelopmental disorders such as intellectual disability and autism spectrum disorder (ASD). Mutations in the POGZ gene disrupt normal function contributing to these conditions. POGZ has connections with ATRX another protein associated with intellectual disabilities. Research continues to explore how these interactions contribute to the pathogenesis of neurodevelopmental disorders offering potential therapeutic targets in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (PubMed : 20562864). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (PubMed : 26721387).
See full target information POGZ
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 42:112867 PubMed37494184

2023

POGZ suppresses 2C transcriptional program and retrotransposable elements.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyun Sun,Tianzhe Zhang,Bei Tong,Linxi Cheng,Wei Jiang,Yuhua Sun

Molecular autism 13:24 PubMed35650610

2022

Autism-associated protein POGZ controls ESCs and ESC neural induction by association with esBAF.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyun Sun,Linxi Cheng,Yuhua Sun

Cell reports 37:110089 PubMed34879283

2021

Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes.

Applications

Unspecified application

Species

Unspecified reactive species

Eirene Markenscoff-Papadimitriou,Fadya Binyameen,Sean Whalen,James Price,Kenneth Lim,Athena R Ypsilanti,Rinaldo Catta-Preta,Emily Ling-Lin Pai,Xin Mu,Duan Xu,Katherine S Pollard,Alex S Nord,Matthew W State,John L Rubenstein

EMBO reports 23:e51041 PubMed34758190

2021

POGZ promotes homology-directed DNA repair in an HP1-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

John Heath,Estelle Simo Cheyou,Steven Findlay,Vincent M Luo,Edgar Pinedo Carpio,Jeesan Lee,Billel Djerir,Xiaoru Chen,Théo Morin,Benjamin Lebeau,Martin Karam,Halil Bagci,Damien Grapton,Josie Ursini-Siegel,Jean-Francois Côté,Michael Witcher,Stéphane Richard,Alexandre Maréchal,Alexandre Orthwein

Nature communications 9:3848 PubMed30242288

2018

The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation.

Applications

Unspecified application

Species

Unspecified reactive species

Ho-Soo Lee,Zhonghui Lin,Sunyoung Chae,Young-Suk Yoo,Byung-Gyu Kim,Youngsoo Lee,Jared L Johnson,You-Sun Kim,Lewis C Cantley,Chang-Woo Lee,Hongtao Yu,Hyeseong Cho
View all publications
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