AB103630

Anti-Poliovirus Receptor/PVR antibody

Name: Anti-Poliovirus Receptor/PVR antibody (ab103630) | Abcam
Brand: Abcam Limited
SKU: AB103630
Price: 535 USD
Availability: InStock
Rating: 3 (3 reviews)

(3 Reviews)

(5 Publications)

Rabbit Polyclonal Poliovirus Receptor/PVR antibody. Carrier free. Suitable for WB and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PVR.

View Alternative Names

CD155, PVS, PVR, Poliovirus receptor, Nectin-like protein 5, NECL-5

2 Images

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Western blot - Anti-Poliovirus Receptor/PVR antibody (AB103630)

All lanes:

Western blot - Anti-Poliovirus Receptor/PVR antibody (ab103630) at 1/500 dilution

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Mouse stomach tissue lysate at 50 µg

Predicted band size: 45 kDa

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Western blot - Anti-Poliovirus Receptor/PVR antibody (AB103630)

All lanes:

Western blot - Anti-Poliovirus Receptor/PVR antibody (ab103630) at 1/500 dilution

Lane 1:

Poliovirus Receptor/PVR transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Predicted band size: 45 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Mouse, Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PVR.

P15151

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The Poliovirus Receptor (PVR) also known as CD155 is a cell surface glycoprotein with a molecular mass of approximately 70 kDa. This receptor is expressed on a variety of cell types including epithelial and endothelial cells immune cells and fibroblasts. Another name for PVR is Necl-5 which falls under the nectin-like molecule family. It acts as an adhesion molecule and contributes to cellular signaling and junctional complexes. The expression of PVR is widespread across multiple tissues but it exhibits stronger expression in areas such as the skin and the gastrointestinal tract.

Biological function summary

The Poliovirus Receptor plays meaningful roles in immune response modulation and cell-cell adhesion. PVR interacts with components of the immune system and forms complexes with other proteins like CD226 and TIGIT. These interactions help regulate immune cell activities especially in the context of natural killer (NK) cells and T-cells. The CD155 protein also links to migration and proliferation processes which are essential for tissue formation and repair.

Pathways

PVR is involved in the regulation of immune and signaling pathways. It fits into pathways like NK cell activation and T-cell inhibitory signaling which are important for maintaining immune tolerance and preventing autoimmunity. In these pathways PVR interacts closely with other immunoregulatory proteins including CD226 and TIGIT. The partnership of PVR with these proteins shapes the delicate balance between immune activation and suppression demonstrating a clear role in immune homeostasis.

PVR relates to conditions such as cancer and viral infection. Its overexpression or altered signaling has been observed in several cancers where it may contribute to tumor growth and immune evasion. The interaction between PVR and its related protein TIGIT can affect antitumor immune responses complicating cancer progression. Additionally as its name suggests PVR binds to the poliovirus facilitating viral entry and spread during infection. This highlights the importance of PVR not only in pathogenic interactions but also in broader immune response contexts.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors : CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.. (Microbial infection) Acts as a receptor for Pseudorabies virus.. (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.

See full target information PVR

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 38:e23440 PubMed38252072

2024

CD155 is essential for skeletal muscle regeneration by regulating satellite cell proliferation and differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Wenpeng Li,Yuan Zhang,Yitian Liu,Chongyang Feng,Chujun Duan,Zhixiang Zhang,Peng Zhao,Ran Zhuang,Yong Ding

Cancer science 111:383-394 PubMed31830330

2020

CD155 contributes to the mesenchymal phenotype of triple-negative breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Qianqian Zheng,Jian Gao,Ping Yin,Wei Wang,Biao Wang,Yan Li,Chenghai Zhao

Molecular medicine reports 20:3773-3781 PubMed31485637

2019

Expression of TIGIT/CD155 and correlations with clinical pathological features in human hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangguo Duan,Juanxi Liu,Jianjian Cui,Bin Ma,Qiunan Zhou,Xiaojuan Yang,Zhenhui Lu,Yong Du,Chunxia Su

Apoptosis : an international journal on programmed cell death 23:512-520 PubMed30039180

2018

CD155 downregulation synergizes with adriamycin to induce breast cancer cell apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Jian Gao,Qianqian Zheng,Yue Shao,Wei Wang,Chenghai Zhao

Journal of cellular and molecular medicine 22:131-140 PubMed28816021

2017

CD155 knockdown promotes apoptosis via AKT/Bcl-2/Bax in colon cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Qianqian Zheng,Biao Wang,Jian Gao,Na Xin,Wei Wang,Xiaowen Song,Yue Shao,Chenghai Zhao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-Poliovirus Receptor/PVR antibody

Western blot - Anti-Poliovirus Receptor/PVR antibody (AB103630)

Western blot - Anti-Poliovirus Receptor/PVR antibody (AB103630)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

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