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AB22450

Anti-Poliovirus (type 1-3) antibody

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(4 Publications)

Goat Polyclonal Poliovirus (type 1-3) antibody. Suitable for ICC/IF and reacts with Enterovirus C samples. Cited in 4 publications. Immunogen corresponding to Virus preparation containing Poliovirus (type 1-3) protein.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Enterovirus C

Applications

ICC/IF

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

Poliovirus Types 1, 2 & 3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Enterovirus C": { "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Proprietary technique
Storage buffer
pH: 7.2 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Poliovirus (type 1-3) also known as human poliovirus is a member of the Enterovirus genus. It is a small non-enveloped virus with an icosahedral capsid. The most common types are 1 2 and 3 each with slight variations in their viral capsid proteins. Poliovirus has an approximate molecular mass of 8.4 kilodaltons for its viral protein 1. It primarily expresses in human cells specifically targeting the gastrointestinal tract where initial replication occurs.
Biological function summary

Polio is a highly contagious viral pathogen responsible for initiating poliomyelitis. The virus targets motor neurons within the spinal cord and the brainstem leading to paralysis. Poliovirus achieves its biological role by interacting with the host cell receptor known as CD155 and not part of a protein complex but acts as a singular threat to CNS tissues.

Pathways

Poliovirus infection involves significant genetic replication and translation processes. This takes place through the cellular machinery of the host particularly using the internal ribosome entry site (IRES) mechanism instead of traditional cap-dependent translation. Related proteins in these pathways include eukaryotic translation initiation factors (eIFs) which are co-opted by the virus to facilitate its replication.

Poliovirus causes poliomyelitis an acute viral condition which can lead to significant neurological impairment including paralysis. The virus spreads through fecal-oral transmission and the potential for neurological damage connects it to proteins like neuron-specific enolase (NSE) commonly released as a result of neuronal injury. Additionally due to its highly infectious nature poliovirus has been studied extensively as part of efforts in eradication programs directly linking it to public health efforts in preventing outbreaks.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Poliovirus (type 1-3)
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 8:593106 PubMed33490061

2021

Modeling Poliovirus Infection Using Human Engineered Neural Tissue Enriched With Motor Neuron Derived From Embryonic Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Érika Cosset,Youssef Hibaoui,Sten Ilmjärv,Pierre-Yves Dietrich,Caroline Tapparel,Karl-Heinz Krause

Vaccines 8: PubMed32443454

2020

Vaccine-Induced Adverse Effects in Cultured Neuroblastoma 2A (N2A) Cells Duplicate Toxicity of Serum from Patients with Gulf War Illness (GWI) and Are Prevented in the Presence of Specific Anti-Vaccine Antibodies.

Applications

Unspecified application

Species

Unspecified reactive species

Effie-Photini C Tsilibary,Eric P Souto,Marian Kratzke,Lisa M James,Brian E Engdahl,Apostolos P Georgopoulos

Scientific reports 10:7939 PubMed32409751

2020

Complexity and ultrastructure of infectious extracellular vesicles from cells infected by non-enveloped virus.

Applications

Unspecified application

Species

Unspecified reactive species

Jie E Yang,Evan D Rossignol,Deborah Chang,Joseph Zaia,Isaac Forrester,Kiran Raja,Holly Winbigler,Daniela Nicastro,William T Jackson,Esther Bullitt

International journal of clinical and experimental 8:3901-6 PubMed26064291

2015

Changes of serum TNF-α, IL-5 and IgE levels in the patients of mycoplasma pneumonia infection with or without bronchial asthma.

Applications

Unspecified application

Species

Unspecified reactive species

Lan Wang,Qiang Chen,Cuiqin Shi,Hanjing Lv,Xianghuai Xu,Li Yu
View all publications
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