Anti-Poliovirus type 3 antibody [45D5]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The replication process of poliovirus type 3 involves cellular mechanisms where the virus hijacks the host's ribosomes for protein synthesis. The viral RNA is directly translated into a polyprotein that is subsequently cleaved by viral proteases into structural and non-structural proteins necessary for viral assembly and replication. These processes take place in the cytoplasm and involve the use of host cellular machinery including membrane vesicle formation. Poliovirus type 3 does not exist as part of a stable complex but interacts transiently with cellular components throughout its lifecycle.

Pathways

Poliovirus type 3 disrupts host cell functions particularly those involved in cellular protein synthesis and apoptosis. It interacts with signaling pathways such as the PI3K/Akt pathway significantly affecting cell survival and death. The virus-induced cleavage of host proteins like eIF4G and the alteration of the host translation machinery are critical for viral propagation and are actions closely linked with these pathways. These interactions enable the virus to evade host immune responses while maximizing its replication.