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AB167368

Anti-POLRMT antibody

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(3 Publications)

Mouse Polyclonal POLRMT antibody. Suitable for WB and reacts with Transfected cell lysate samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human POLRMT.

View Alternative Names

MtRPOL, POLRMT

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human POLRMT.

O00411

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Transfected cell lysate": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p>This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed : 21278163, PubMed : 33602924). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed : 29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed : 29149603). Has DNA primase activity (PubMed : 18685103, PubMed : 33602924). Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL) (PubMed : 18685103, PubMed : 33602924).
See full target information POLRMT
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

The EMBO journal 43:2337-2367 PubMed38649537

2024

SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.

Applications

Unspecified application

Species

Unspecified reactive species

Weiwei Yan,Chengmei Xie,Sijun Sun,Quan Zheng,Jingyi Wang,Zihao Wang,Cheuk-Him Man,Haiyan Wang,Yunfan Yang,Tianshi Wang,Leilei Shi,Shengjie Zhang,Chen Huang,Shuangnian Xu,Yi-Ping Wang

Cell metabolism 33:1027-1041.e8 PubMed33770508

2021

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Ping Wang,Azeem Sharda,Shuang-Nian Xu,Nick van Gastel,Cheuk Him Man,Una Choi,Wei Zhong Leong,Xi Li,David T Scadden

Molecular medicine reports 20:1113-1120 PubMed31173210

2019

Electroacupuncture alleviates morphine‑induced hyperalgesia by regulating spinal CB1 receptors and ERK1/2 activity.

Applications

Unspecified application

Species

Unspecified reactive species

Yuxin Zheng,Yang Yu,Keliang Xie,Yuan Yuan,Yi Chen,Chunyan Wang,Guolin Wang,Yonghao Yu
View all publications
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Product promise

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