AB96196

Anti-Polymeric immunoglobulin receptor/PIGR antibody

Name: Anti-Polymeric immunoglobulin receptor/PIGR antibody (ab96196) | Abcam
Brand: Abcam Limited
SKU: AB96196
Price: 450 USD
Availability: InStock
Rating: 4 (5 reviews)

(5 Reviews)

(11 Publications)

Anti-Polymeric immunoglobulin receptor/PIGR antibody (ab96196) is a rabbit polyclonal antibody detecting Polymeric immunoglobulin receptor/PIGR in Western Blot, IHC-P, ICC/IF. Suitable for Human.

- Trusted since 2010

View Alternative Names

Polymeric immunoglobulin receptor, PIgR, Poly-Ig receptor, Hepatocellular carcinoma-associated protein TB6, PIGR

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Polymeric immunoglobulin receptor/PIGR antibody (AB96196)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Polymeric immunoglobulin receptor/PIGR antibody (AB96196)

ab96196 at 1/500 dilution staining Polymeric immunoglobulin receptor/PIGR in paraffin-embedded Cal27 xenograft tissue.

Immunocytochemistry/ Immunofluorescence - Anti-Polymeric immunoglobulin receptor/PIGR antibody (AB96196)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Polymeric immunoglobulin receptor/PIGR antibody (AB96196)

ab96196 at 1/200 dilution staining Polymeric immunoglobulin receptor/PIGR in methanol fixed HepG2 cells. Lower image is co-stained with Hoechst 33342.

Unknown

Western blot - Anti-Polymeric immunoglobulin receptor/PIGR antibody (AB96196)

All lanes:

Western blot - Anti-Polymeric immunoglobulin receptor/PIGR antibody (ab96196) at 1/1000 dilution

All lanes:

Molt4 whole cell lysate at 30 µg

Predicted band size: 83 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PIGR aa 150-450. The exact immunogen used to generate this antibody is proprietary information.

P01833

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/300 - 1/500", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/200", "ICCIF-species-notes": "" } } }

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Product details

What is this antibody validated in?
Anti-Polymeric immunoglobulin receptor/PIGR antibody (ab96196) is a rabbit polyclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P), Immunocytochemistry/immunofluorescence (ICC/IF) in Human samples.

What is the molecular weight of Polymeric immunoglobulin receptor/PIGR?
Anti-Polymeric immunoglobulin receptor/PIGR (ab96196) specifically detects a band for Polymeric immunoglobulin receptor/PIGR (UniProt: P01833) at a molecular weight of 83kDa.

Reviewed by scientists
Anti-Polymeric immunoglobulin receptor/PIGR (ab96196) has over 5 independent reviews from customers.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The polymeric immunoglobulin receptor often referred to as PIGR or the polymeric Ig receptor is a critical component in the immune system. This protein which has a mass of approximately 83 kDa is expressed primarily on the basolateral surface of epithelial cells. Common expression sites include the respiratory gastrointestinal and genital tracts. PIGR facilitates the transcytosis of polymeric immunoglobulins like IgA and IgM across epithelial cells ensuring that these antibodies reach mucosal sites where they perform functions.

Biological function summary

The polymeric immunoglobulin receptor plays an essential role in mucosal immunity by transporting IgA and IgM antibodies to mucosal surfaces. The PIGR is a part of a complex that includes the secretory component which protects immunoglobulins from proteolytic degradation. This mechanism is fundamental for safeguarding mucosal surfaces while allowing the immune system to respond swiftly to pathogens.

Pathways

The interaction of PIGR with polymeric immunoglobulins is an important event in the mucosal immune pathway. This pathway is important in maintaining mucosal homeostasis and pathogen defense. PIGR works closely with immunoglobulin proteins like IgA and IgM enabling their rapid and efficient transport across epithelial barriers. This ensures that the immune system rapidly addresses potential threats at mucosal sites.

Defects in PIGR function can lead to conditions like IgA nephropathy and selective IgA deficiency. These disorders highlight the importance of the polymeric Ig receptor in immune health and suggest its role in maintaining immunoglobulin balance. There is evidence suggesting potential connections between PIGR dysfunction and the proteins involved in immune regulation which helps in understanding how PIGR contributes to disease pathology.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Polymeric immunoglobulin receptor. Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.. Secretory component. Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed : 12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed : 16543244).

See full target information PIGR

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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 23:747 PubMed40624587

2025

Immunoglobulin A/PIGR axis as potential mediators of human abdominal aortic aneurysms revealed by topologically resolved proteomics.

Applications

Unspecified application

Species

Unspecified reactive species

Isabel Cerro-Pardo,Estefanía Núñez,Belén Picatoste,Cristina Márquez-Gálvez,Lucía Ortega-Villanueva,Irene Raposo-Gutiérrez,Jes S Lindholt,Luis Miguel Blanco-Colio,Almudena R Ramiro,Jesús Vázquez,José Luis Martín-Ventura

Immunity 56:2570-2583.e6 PubMed37909039

2023

Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers.

Applications

Unspecified application

Species

Unspecified reactive species

Subir Biswas,Gunjan Mandal,Carmen M Anadon,Ricardo A Chaurio,Luis U Lopez-Bailon,Mate Z Nagy,Jessica A Mine,Kay Hänggi,Kimberly B Sprenger,Patrick Innamarato,Carly M Harro,John J Powers,Joseph Johnson,Bin Fang,Mostafa Eysha,Xiaolin Nan,Roger Li,Bradford A Perez,Tyler J Curiel,Xiaoqing Yu,Paulo C Rodriguez,Jose R Conejo-Garcia

Cancer research 82:859-871 PubMed34949671

2021

IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Gunjan Mandal,Subir Biswas,Carmen M Anadon,Xiaoqing Yu,Chandler D Gatenbee,Sandhya Prabhakaran,Kyle K Payne,Ricardo A Chaurio,Alexandra Martin,Patrick Innamarato,Carlos Moran,John J Powers,Carly M Harro,Jessica A Mine,Kimberly B Sprenger,Kristen E Rigolizzo,Xuefeng Wang,Tyler J Curiel,Paulo C Rodriguez,Alexander R Anderson,Ozlen Saglam,Jose R Conejo-Garcia

Veterinary research communications 46:79-91 PubMed34559380

2021

Assessment of intestinal macromolecular absorption in young piglets to pave the way to oral vaccination: preliminary results.

Applications

Unspecified application

Species

Unspecified reactive species

Brodie Deluco,Heather L Wilson

Nature 591:464-470 PubMed33536615

2021

IgA transcytosis and antigen recognition govern ovarian cancer immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Subir Biswas,Gunjan Mandal,Kyle K Payne,Carmen M Anadon,Chandler D Gatenbee,Ricardo A Chaurio,Tara Lee Costich,Carlos Moran,Carly M Harro,Kristen E Rigolizzo,Jessica A Mine,Jimena Trillo-Tinoco,Naoko Sasamoto,Kathryn L Terry,Douglas Marchion,Andrea Buras,Robert M Wenham,Xiaoqing Yu,Mary K Townsend,Shelley S Tworoger,Paulo C Rodriguez,Alexander R Anderson,Jose R Conejo-Garcia

Oncology reports 44:252-262 PubMed32627041

2020

High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ryotaro Ohkuma,Erica Yada,Shumpei Ishikawa,Daisuke Komura,Yutaro Kubota,Kazuyuki Hamada,Atsushi Horiike,Tomoyuki Ishiguro,Yuya Hirasawa,Hirotsugu Ariizumi,Midori Shida,Makoto Watanabe,Rie Onoue,Kiyohiro Ando,Junji Tsurutani,Kiyoshi Yoshimura,Tetsuro Sasada,Takeshi Aoki,Masahiko Murakami,Tomoko Norose,Nobuyuki Ohike,Masafumi Takimoto,Shinichi Kobayashi,Takuya Tsunoda,Satoshi Wada

Journal of cancer research and therapeutics 15:420-425 PubMed30964121

2019

Expression of polymeric immunoglobulin receptor and its biological function in endometrial adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Mingshu Zhou,Chongdong Liu,Guangming Cao,Huiqiao Gao,Zhenyu Zhang

ACS omega 4:1272-1280 PubMed30729226

2019

Glycoproteomic Profiling Provides Candidate Myocardial Infarction Predictors of Later Progression to Heart Failure.

Applications

Unspecified application

Species

Unspecified reactive species

Kristine Y Deleon-Pennell,Osasere K Ero,Yonggang Ma,Rugmani Padmanabhan Iyer,Elizabeth R Flynn,Ingrid Espinoza,Solomon K Musani,Ramachandran S Vasan,Michael E Hall,Ervin R Fox,Merry L Lindsey

Biomolecules 8: PubMed30453527

2018

Giantin Is Required for Post-Alcohol Recovery of Golgi in Liver Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Carol A Casey,Paul Thomes,Sonia Manca,Armen Petrosyan

Experimental and therapeutic medicine 16:4367-4372 PubMed30542385

2018

A study on the mechanism of agonists in regulating transcriptional level of pIgR in salivary gland epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Li Huang,Chuankong Sun,Ruobing Peng,Zhiming Liu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Polymeric immunoglobulin receptor/PIGR antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Polymeric immunoglobulin receptor/PIGR antibody (AB96196)

Immunocytochemistry/ Immunofluorescence - Anti-Polymeric immunoglobulin receptor/PIGR antibody (AB96196)

Western blot - Anti-Polymeric immunoglobulin receptor/PIGR antibody (AB96196)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (11)

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