Anti-PPIL3 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PPIL3 or Peptidylprolyl isomerase (cyclophilin)-like 3 is an enzyme that assists in protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. It weighs approximately 52 kDa. PPIL3 expression can be found in various tissues including liver and thymus. The protein acts as a member of the cyclophilin family which is known for its role in protein folding and immunosuppression.

Biological function summary

The function of PPIL3 includes its contribution to the assembly of spliceosomal complexes. It interacts with other proteins to aid the splicing of pre-mRNA therefore influencing gene expression regulation. Though PPIL3 operates independently it often localizes within multiprotein complexes involved in RNA processing. Its role in the spliceosome highlights its importance in the accurate and efficient editing of RNA transcripts.

Pathways

PPIL3 participates in the RNA splicing and gene expression pathways. Within these pathways PPIL3 shows interactions with the spliceosomal proteins such as U2 small nuclear ribonucleoprotein highlighting its contribution to mRNA splicing regulation. It involves itself in adjusting the splicing machinery's fine-tuning ensuring correct mRNA processing essential for cellular functions.

Associated diseases and disorders

PPIL3 has links to conditions such as cancer and neurodegeneration. Its role in RNA splicing means that any dysfunction resulting in spliceosomal assembly errors can contribute to diseases like cancer where incorrect mRNA splicing leads to aberrant gene expression. PPIL3 is also associated with cyclophilin B through their overlapping functions in protein folding and transport which can become impaired in neurodegenerative disorders.