Rabbit Polyclonal PPP1R11 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PPP1R11 aa 1 to C-terminus.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
Lyophilized
Polyclonal
WB | IHC-P | |
---|---|---|
Human | Tested | Tested |
Rat | Predicted | Predicted |
Chimpanzee | Predicted | Predicted |
Rhesus monkey | Predicted | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/200.00000 - 1/1000.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Rat, Chimpanzee, Rhesus monkey | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Rat, Chimpanzee, Rhesus monkey | Dilution info - | Notes - |
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Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442).
HCGV, TCTE5, PPP1R11, TCTE5, HCGV, E3 ubiquitin-protein ligase PPP1R11, Hemochromatosis candidate gene V protein, Protein phosphatase 1 regulatory subunit 11, Protein phosphatase inhibitor 3, HCG V
Rabbit Polyclonal PPP1R11 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PPP1R11 aa 1 to C-terminus.
IgG
Rabbit
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA
Lyophilized
Polyclonal
Affinity purification Immunogen
Reconstitute in 200ul Sterile Distilled Water.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
PPP1R11 also known as Protein Phosphatase 1 Regulatory Inhibitor Subunit 11 is a protein that acts as an inhibitor of protein phosphatase 1 (PP1) activity. It weighs approximately 14 kDa and is expressed in various tissues with higher levels in the testis and less in other tissues. Its primary role involves binding to PP1 a critical enzyme in the regulation of phosphorylation states within cells and modulating its activity.
The protein regulates the phosphorylation process which is vital for cellular functions. PPP1R11 does not work in isolation; it forms part of a complex with PP1 influencing the enzyme's ability to dephosphorylate target substrates. This function is essential in controlling cell division protein synthesis and muscle contractility through its inhibition effect on PP1.
PPP1R11 contributes significantly to cellular signaling pathways. It plays a role in the cell cycle regulation pathway and also the glycogen metabolism pathway. Within these pathways it interacts with PP1 and other regulatory proteins to maintain proper cellular functions and energy management. Alterations in these interactions can lead to dysregulation exhibiting the target's importance in cell physiology.
The alterations in the function or expression of PPP1R11 link to certain cancers and metabolic conditions. Its connection with PP1 shows a relationship with cancer through irregular cell cycle control. Furthermore its role in glycogen metabolism can relate to disorders like type 2 diabetes highlighting the interaction with insulin-regulatory proteins. Understanding PPP1R11’s function can help develop potential interventions for these conditions.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human stomach tissue labeling PPP1R11 with ab177043 at 1/100 dilution.
All lanes: Western blot - Anti-PPP1R11 antibody (ab177043) at 1/1000 dilution
All lanes: HepG2 cell lysate
Predicted band size: 14 kDa
Observed band size: 18 kDa
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