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Rabbit Polyclonal PPP1R11 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PPP1R11 aa 1 to C-terminus.


Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP1R11 antibody (AB177043), expandable thumbnail
  • Western blot - Anti-PPP1R11 antibody (AB177043), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 98% PBS, 1% BSA

Form

Lyophilized

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human PPP1R11 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O60927

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested
Rat
Predicted
Predicted
Chimpanzee
Predicted
Predicted
Rhesus monkey
Predicted
Predicted

Tested
Tested

Species

Human

Dilution info

1/200.00000 - 1/1000.00000

Notes

-

Predicted
Predicted

Species

Rat, Chimpanzee, Rhesus monkey

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

1/100.00000 - 1/500.00000

Notes

-

Predicted
Predicted

Species

Rat, Chimpanzee, Rhesus monkey

Dilution info

-

Notes

-

Associated Products

Select an associated product type

1 product for Alternative Product

Target data

Function

Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442).

Alternative names

Recommended products

Rabbit Polyclonal PPP1R11 antibody. Suitable for WB, IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human PPP1R11 aa 1 to C-terminus.

Key facts

Isotype

IgG

Form

Lyophilized

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human PPP1R11 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O60927
Purification technique

Affinity purification Immunogen

Reconstitution

Reconstitute in 200ul Sterile Distilled Water.

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PPP1R11 also known as Protein Phosphatase 1 Regulatory Inhibitor Subunit 11 is a protein that acts as an inhibitor of protein phosphatase 1 (PP1) activity. It weighs approximately 14 kDa and is expressed in various tissues with higher levels in the testis and less in other tissues. Its primary role involves binding to PP1 a critical enzyme in the regulation of phosphorylation states within cells and modulating its activity.

Biological function summary

The protein regulates the phosphorylation process which is vital for cellular functions. PPP1R11 does not work in isolation; it forms part of a complex with PP1 influencing the enzyme's ability to dephosphorylate target substrates. This function is essential in controlling cell division protein synthesis and muscle contractility through its inhibition effect on PP1.

Pathways

PPP1R11 contributes significantly to cellular signaling pathways. It plays a role in the cell cycle regulation pathway and also the glycogen metabolism pathway. Within these pathways it interacts with PP1 and other regulatory proteins to maintain proper cellular functions and energy management. Alterations in these interactions can lead to dysregulation exhibiting the target's importance in cell physiology.

Associated diseases and disorders

The alterations in the function or expression of PPP1R11 link to certain cancers and metabolic conditions. Its connection with PP1 shows a relationship with cancer through irregular cell cycle control. Furthermore its role in glycogen metabolism can relate to disorders like type 2 diabetes highlighting the interaction with insulin-regulatory proteins. Understanding PPP1R11’s function can help develop potential interventions for these conditions.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
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2 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP1R11 antibody (ab177043), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PPP1R11 antibody (ab177043)

    Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human stomach tissue labeling PPP1R11 with ab177043 at 1/100 dilution.

  • Western blot - Anti-PPP1R11 antibody (ab177043), expandable thumbnail

    Western blot - Anti-PPP1R11 antibody (ab177043)

    All lanes: Western blot - Anti-PPP1R11 antibody (ab177043) at 1/1000 dilution

    All lanes: HepG2 cell lysate

    Predicted band size: 14 kDa

    Observed band size: 18 kDa

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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