Anti-PPP2R2A antibody [2G9]

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Protein phosphatase 2 regulatory subunit B alpha (PPP2R2A) also known as B55α is a regulatory component of the protein phosphatase 2 (PP2A) complex. It is a 55 kDa subunit that modulates PP2A activity and substrate specificity. PPP2R2A is widely expressed in various human tissues with high levels in the brain heart and skeletal muscle. This regulatory subunit helps control the dephosphorylation of serine/threonine residues on target proteins playing an important role in cellular processes by directing the substrate selection of the PP2A complex.

Biological function summary

PPP2R2A influences several cellular processes through its integration into the PP2A holoenzyme complex. It directs the dephosphorylation of proteins like MAP kinases which are important for signal transduction. By associating with the catalytic and scaffolding subunits of PP2A PPP2R2A modulates cell cycle progression apoptosis and DNA replication. Its involvement in these processes highlights its importance in maintaining cellular homeostasis and function.

Pathways

PPP2R2A is integral to the MAPK/ERK and PI3K/AKT signaling pathways. It regulates the activity of several kinases and phosphatases in these pathways influencing cell growth and survival. In the MAPK/ERK pathway PPP2R2A interacts with proteins like MEK and ERK while in the PI3K/AKT pathway it can connect with the phosphatase PTEN highlighting its regulatory roles in critical cellular signaling networks.

PPP2R2A has been associated with cancer and neurodegenerative diseases. Its dysregulation can lead to aberrant cell proliferation as often seen in certain cancers. For instance altered expression of PPP2R2A has been noted in prostate cancer. In neurodegenerative conditions like Alzheimer's disease PPP2R2A interacts with tau protein affecting tau phosphorylation and potentially contributing to disease progression. The involvement of PPP2R2A in these diseases highlights its relevance as a potential therapeutic target.