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AB27269

Anti-PPP2R2C antibody

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(2 Publications)

Rabbit Polyclonal PPP2R2C antibody. Suitable for WB and reacts with Mouse, Rat, Human, Cow samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PPP2R2C aa 50-100 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform, IMYPNO1, PP2A subunit B isoform B55-gamma, PP2A subunit B isoform PR55-gamma, PP2A subunit B isoform R2-gamma, PP2A subunit B isoform gamma, PPP2R2C

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Cow, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human PPP2R2C aa 50-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9Y2T4

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Precipitation Ammonium Sulphate
Storage buffer
Preservative: 0.08% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Protein phosphatase 2 regulatory subunit B gamma also known as PPP2R2C or B55-gamma is a regulatory subunit of protein phosphatase 2A (PP2A). It exhibits a molecular mass of approximately 55 kDa. PPP2R2C is expressed in various tissues with higher levels found in the brain and testis. By associating with the core PP2A enzyme it modulates substrate specificity catalytic activity and subcellular localization playing a significant role in PP2A function.
Biological function summary

The protein serves as a regulatory component of the PP2A holoenzyme which consists of a structural A subunit catalytic C subunit and regulatory B subunit like PPP2R2C. This complex performs dephosphorylation functions essential for cell cycle regulation and signal transduction. By coupling with PP2A PPP2R2C influences key cellular processes such as cell growth and differentiation by modulating phosphorylation states of critical proteins.

Pathways

This regulatory subunit PPP2R2C integrates into the PI3K/AKT and MAPK signaling pathways. It serves as a modulatory bridge affecting specific protein interactions and phosphorylation events. Through these pathways PPP2R2C connects with proteins like AKT and ERK coordinating signals that regulate cell survival and proliferation while maintaining balanced phosphatase activity.

PPP2R2C associates with neurodegenerative disorders and certain cancers. Aberrations in PP2A activity regulated by PPP2R2C can lead to Alzheimer's disease where abnormal phosphorylation plays a role in tau protein aggregation. In oncology disruptions in PPP2R2C function may contribute to glioblastoma progression due to altered signaling pathways. These conditions highlight the connection of PPP2R2C with key proteins involved in disease underpinning its relevance in therapeutic research.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
See full target information PPP2R2C
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 21:793 PubMed37940996

2023

Muc2 mucin O-glycosylation interacts with enteropathogenic Escherichia coli to influence the development of ulcerative colitis based on the NF-kB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Wei,Chunyan Chen,Jing Feng,Shuping Zhou,Xiaoyue Feng,Zhao Yang,Heng Lu,Hui Tao,Liuying Li,Huabing Xv,Ji Xuan,Fangyu Wang

Investigative ophthalmology & visual science 61:10 PubMed33049058

2020

Protein Phosphatase 2A and Clathrin-Mediated Endocytosis Facilitate Robust Melanopsin Light Responses and Resensitization.

Applications

Unspecified application

Species

Unspecified reactive species

Juan C Valdez-Lopez,Meheret Gebreegziabher,Robin J Bailey,Jair Flores,Olanike Awotunde,Thomas Burnett,Phyllis R Robinson
View all publications
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