Anti-PPP2R2D antibody [EPR13624] - BSA and Azide free

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The PPP2R2D protein also known as B regulatory subunit of phosphatase 2A (B55-Delta) is a part of the protein phosphatase 2 (PP2A) complex. It is an important element of the holoenzyme PP2A with an approximate molecular mass of 55 kilodaltons. This protein is expressed widely in human tissues including the brain and liver. PPP2R2D functions by regulating PP2A activity affecting various substrates and controlling the dephosphorylation process.

Biological function summary

PPP2R2D plays a role in cell cycle regulation and apoptosis. As a regulatory subunit of the PP2A complex it modulates the enzyme’s activity and substrate specificity. This control makes PPP2R2D important in the mitotic spindle checkpoint facilitating proper chromosome segregation. Its influence on cell cycle arrest and apoptosis emerges from its ability to target several key signaling molecules thereby ensuring proper cell function and survival.

Pathways

The PP2A complex containing PPP2R2D is integral to the MAPK/ERK and PI3K/AKT pathways. Through these pathways PPP2R2D influences cellular processes like growth differentiation and survival. Related proteins in these pathways include RAF and AKT which interact with PP2A peptides to stabilize the signaling environment. PPP2R2D's functionality ensures the pathways remain balanced enabling cells to maintain normal physiological functions.

Associated diseases and disorders

Aberrant expression or mutation of PPP2R2D associates with cancers and neurodegenerative diseases. In cancer altered PP2A activity often linked with related proteins such as MYC contributes to uncontrolled cell proliferation. Similarly in neurological conditions like Alzheimer's disease the dysregulation of PP2A-related processes can lead to tau hyperphosphorylation highlighting deficiencies in the apoptotic pathways. Understanding PPP2R2D's role can therefore highlight potential therapeutic targets for these conditions.