Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
Learn about all product ranges with our product overviews.
Featured events
Make new connections at our global events.
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Product Insider Program
Be the first to know about our latest product launches - and unlock exclusive offers and discounts.
Rabbit Polyclonal PPP3CC antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human PPP3CC conjugated to Keyhole Limpet Haemocyanin.
IgG
Rabbit
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
IHC-P | |
---|---|
Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 5 µg/mL | Notes - |
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, CNA3, PPP3CC, CALNA3
Rabbit Polyclonal PPP3CC antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human PPP3CC conjugated to Keyhole Limpet Haemocyanin.
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, CNA3, PPP3CC, CALNA3
IgG
Rabbit
pH: 7.4
Preservative: 0.09% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Precipitation Ammonium Sulphate
Blue Ice
Up to 6 months
+4°C
-20°C
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
The protein phosphatase 3 complex involves PPP3CC which contributes to numerous cellular signaling pathways by regulating intracellular levels of calcium. This regulation impacts synaptic transmission neuronal excitability and immune responses. In the neuronal context it helps modulate pathways associated with long-term potentiation and learning by influencing the recruitment and function of neurotransmitter receptors.
The PPP3CC gene encodes the catalytic subunit of the protein phosphatase 3 also known as calcineurin gamma which weighs approximately 58 kDa. This enzyme acts as a calcium/calmodulin-dependent serine/threonine phosphatase that modulates various cellular functions by dephosphorylating target proteins. It is widely expressed across various tissues but its presence is significant in the brain where it plays an important part in neural signaling and synaptic plasticity.
PPP3CC contributes a regulatory role to the calcium signaling pathway and the calcineurin-NFAT pathway. In these pathways it interacts with and dephosphorylates the NFAT transcription factors influencing gene transcription related to immune response and neural activities. Through these interactions it shares functional relationships with other proteins like NFAT and calmodulin which also participate in these pathways.
Irregular activity of PPP3CC links to neurological disorders such as Alzheimer’s disease and schizophrenia. Altered calcineurin signaling involving the PPP3CC subunit associates with disrupted synaptic functions and neuronal communication in these conditions. Furthermore in Alzheimer's disease the dysregulation may involve other proteins like tau or amyloid precursor protein influencing disease progression and severity.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
ab118893 at 5μg/ml, staining PPP3CC in Formalin-fixed, Paraffin-embedded Human Prostate tissue by Immunohistochemistry.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com