AB154863

Anti-PPP3CC antibody [EPR10601]

RabMAb
Recombinant
What is this?

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(3 Publications)

Rabbit Recombinant Monoclonal PPP3CC antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

View Alternative Names

CALNA3, CNA3, PPP3CC, Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform

1 Images

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Western blot - Anti-PPP3CC antibody [EPR10601] (AB154863)

All lanes:

Western blot - Anti-PPP3CC antibody [EPR10601] (ab154863) at 1/1000 dilution

Lane 1:

Jurkat cell lysate at 10 µg

Lane 2:

Human fetal brain tissue lysate at 10 µg

Predicted band size: 58 kDa

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Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR10601

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purity

Tissue culture supernatant

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PPP3CC gene encodes the catalytic subunit of the protein phosphatase 3 also known as calcineurin gamma which weighs approximately 58 kDa. This enzyme acts as a calcium/calmodulin-dependent serine/threonine phosphatase that modulates various cellular functions by dephosphorylating target proteins. It is widely expressed across various tissues but its presence is significant in the brain where it plays an important part in neural signaling and synaptic plasticity.

Biological function summary

The protein phosphatase 3 complex involves PPP3CC which contributes to numerous cellular signaling pathways by regulating intracellular levels of calcium. This regulation impacts synaptic transmission neuronal excitability and immune responses. In the neuronal context it helps modulate pathways associated with long-term potentiation and learning by influencing the recruitment and function of neurotransmitter receptors.

Pathways

PPP3CC contributes a regulatory role to the calcium signaling pathway and the calcineurin-NFAT pathway. In these pathways it interacts with and dephosphorylates the NFAT transcription factors influencing gene transcription related to immune response and neural activities. Through these interactions it shares functional relationships with other proteins like NFAT and calmodulin which also participate in these pathways.

Irregular activity of PPP3CC links to neurological disorders such as Alzheimer’s disease and schizophrenia. Altered calcineurin signaling involving the PPP3CC subunit associates with disrupted synaptic functions and neuronal communication in these conditions. Furthermore in Alzheimer's disease the dysregulation may involve other proteins like tau or amyloid precursor protein influencing disease progression and severity.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.

See full target information PPP3CC

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 13:817213 PubMed35295332

2022

Chinese Herbal Extracts Exert Neuroprotective Effect in Alzheimer's Disease Mouse Through the Dopaminergic Synapse/Apoptosis Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qianqian Huang,Chen Zhang,Sihao Qu,Shi Dong,Qihong Ma,Ying Hao,Zimin Liu,Shanglong Wang,Haibin Zhao,Yuanyuan Shi

Autophagy 15:565-582 PubMed30324847

2018

AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Huifeng Pi,Min Li,Lingyun Zou,Min Yang,Ping Deng,Tengfei Fan,Menyu Liu,Li Tian,Manyu Tu,Jia Xie,Mengyan Chen,Huijuan Li,Yu Xi,Lei Zhang,Mindi He,Yonghui Lu,Chunhai Chen,Tao Zhang,Zheng Wang,Zhengping Yu,Feng Gao,Zhou Zhou

Cell reports 22:1695-1709 PubMed29444424

2018

Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism.

Applications

Species

Mouse

Rashi Priya,Mercedes Francisca Paredes,Theofanis Karayannis,Nusrath Yusuf,Xingchen Liu,Xavier Jaglin,Isabella Graef,Arturo Alvarez-Buylla,Gord Fishell

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PPP3CC antibody [EPR10601]

Western blot - Anti-PPP3CC antibody [EPR10601] (AB154863)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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Product promise