Mouse Monoclonal PR3 antibody. Suitable for Flow Cyt, ELISA, WB, IHC-P, FuncS (Neut/Block), IHC-Fr and reacts with Human samples. Cited in 14 publications.
View Alternative Names
MBN, PRTN3, Myeloblastin, AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen, PR-3, PR3, NP-4
Reactivity data
Product details
Properties and storage information
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Purification technique
Purification notes
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Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
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Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Proteinase 3 serves multiple roles including modulating inflammation and immune responses. PR3 functions as part of a complex with azurophilic granules aiding in microbial defense mechanisms. In addition the protease regulates cytokine activation and deactivation which in turn influences cell signaling related to inflammation. Its enzymatic action ensures that PR3 can manage inflammatory processes by breaking down extracellular matrix components thereby allowing white blood cells to access infection sites.
Pathways
Proteinase 3 plays an important role within the serine protease and inflammatory pathways. It interacts with other proteins such as neutrophil elastase with which it shares a pathway to modulate immune responses. PR3 also partners with cathepsin G contributing to processes such as pathogen clearance and tissue remodeling providing a coordinated response during infection and injury. These interactions show PR3's involvement in regulating the balance between inflammation and tissue repair.
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Target data
Publications (14)
Recent publications for all applications. Explore the full list and refine your search
Redox biology 74:103231 PubMed38861835
2024
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Unspecified application
Species
Unspecified reactive species
Oncoimmunology 11:2052418 PubMed35309732
2022
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Unspecified application
Species
Unspecified reactive species
BMC immunology 20:22 PubMed31248381
2019
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Unspecified application
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Unspecified reactive species
Journal of the American Chemical Society 139:10115-10125 PubMed28672107
2017
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Unspecified application
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Unspecified reactive species
Disease models & mechanisms 9:885-97 PubMed27483354
2016
Applications
Unspecified application
Species
Human
PloS one 9:e110677 PubMed25330301
2014
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Unspecified application
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Unspecified reactive species
Arthritis research & therapy 16:R142 PubMed25000985
2014
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Unspecified application
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Unspecified reactive species
Innate immunity 20:440-8 PubMed24189124
2013
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Unspecified application
Species
Human
Journal of immunology (Baltimore, Md. : 1950) 189:5476-84 PubMed23105141
2012
Applications
Unspecified application
Species
Unspecified reactive species
PloS one 7:e38317 PubMed22675451
2012
Applications
Flow Cyt
Species
Human
Product promise
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