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AB121856

Anti-PRAX-1 antibody

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(2 Publications)

Rabbit Polyclonal PRAX-1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TSPOAP1 aa 1150-1300.

View Alternative Names

BZRAP1, KIAA0612, RBP1, RIMBP1, TSPOAP1, Peripheral-type benzodiazepine receptor-associated protein 1, PRAX-1, Peripheral benzodiazepine receptor-interacting protein, RIMS-binding protein 1, TSPO-associated protein 1, PBR-IP, RIM-BP1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRAX-1 antibody (AB121856)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRAX-1 antibody (AB121856)

ab121856, at 1/40 dilution, staining PRAX-1 in squamous epithelial cells of paraffin-embedded Human esophagus by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human TSPOAP1 aa 1150-1300. The exact immunogen used to generate this antibody is proprietary information.

O95153

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PRAX-1 also called Proline-Rich Anxious (PRAX) Protein 1 is a protein involved in neuronal signaling processes. Its molecular mass is approximately 28 kDa. The protein shows strong expression in the central nervous system notably within neurons. PRAX-1 has regions rich in proline which facilitates interactions with other proteins. These interactions hint that the protein could have multifunctional roles in cellular environments where it is expressed.
Biological function summary

PRAX-1 aids in the regulation of neuronal signal transduction mechanisms. It does not usually function as part of a large protein complex. It acts independently to influence synaptic functions and neural plasticity suggesting its role in adapting neuron signaling to various stimuli. This function is essential in maintaining healthy neuron communication and may impact learning and memory processes within the brain.

Pathways

PRAX-1 operates within the MAP kinase signaling cascade a pathway important for transmitting extracellular signals to elicit cellular responses. The intricate interaction with other signaling proteins such as Ras and ERK signifies PRAX-1's involvement in modulating these pathways. These connections position PRAX-1 as a potential regulator at multiple levels of cell signaling networks impacting various cellular responses.

PRAX-1 has links to anxious behavior which can arise from abnormal neuronal signaling. Researchers connect dysfunction in this protein with anxiety-related conditions. Furthermore PRAX-1 interacts with GABAergic signaling involving GABA receptors which play a role in anxiety disorders. The protein’s altered function may therefore contribute significantly to the pathophysiology of these mental health disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Required for synaptic transmission regulation (PubMed : 33539324). It probably controls the recruitment of voltage-gated calcium channels to the presynaptic membrane, and modulates neurotransmitter release.
See full target information TSPOAP1
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 40:111397 PubMed36170822

2022

Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Sarni,Sonia Barroso,Alon Shtrikman,Michal Irony-Tur Sinai,Yifat S Oren,Andrés Aguilera,Batsheva Kerem

Frontiers in pharmacology 11:270 PubMed32317960

2020

microRNA-155 Modulates Hepatic Stellate Cell Proliferation, Apoptosis, and Cell Cycle Progression in Rats With Alcoholic Hepatitis the MAPK Signaling Pathway Through Targeting SOCS1.

Applications

Unspecified application

Species

Unspecified reactive species

Dengtao Liu,Ping Han,Chunhai Gao,Wei Gao,Xiaocui Yao,Shulan Liu
View all publications
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Product promise

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