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AB231526

Anti-PRCP antibody

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(1 Publication)

Rabbit Polyclonal PRCP antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Lysosomal Pro-X carboxypeptidase aa 150-450.

View Alternative Names

Lysosomal Pro-X carboxypeptidase, Proline carboxypeptidase, Prolylcarboxypeptidase, PRCP, Prcp

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRCP antibody (AB231526)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRCP antibody (AB231526)

Formalin-fixed, paraffin-embedded mouse kidney tissue stained for PRCP using ab231526 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-PRCP antibody (AB231526)
  • WB

Supplier Data

Western blot - Anti-PRCP antibody (AB231526)

All lanes:

Western blot - Anti-PRCP antibody (ab231526) at 2 µg/mL

All lanes:

Mouse kidney lysate

Predicted band size: 56 kDa

false

Western blot - Anti-PRCP antibody (AB231526)
  • WB

Supplier Data

Western blot - Anti-PRCP antibody (AB231526)

All lanes:

Western blot - Anti-PRCP antibody (ab231526) at 2 µg/mL

All lanes:

Recombinant mouse PRCP protein

Predicted band size: 47 kDa,50 kDa,56 kDa,94 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Mouse Lysosomal Pro-X carboxypeptidase aa 150-450. The exact immunogen used to generate this antibody is proprietary information.

Q7TMR0

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab231526 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The PRCP protein also known as Prolylcarboxypeptidase is an enzyme with a molecular weight of around 55 kDa. It functions mechanically by cleaving C-terminal proline residues from peptides. This protein localizes in different tissues including the kidney brain and liver. Its expression is not limited to these areas and can be found in varying levels throughout other tissues in the body.
Biological function summary

PRCP plays a role in several physiological processes including blood pressure regulation and appetite control. It acts as part of a complex involved in degrading peptide hormones like angiotensin II. By modulating these peptide hormones PRCP influences the renin-angiotensin system which is critical for blood pressure homeostasis. The regulation of neuropeptides also impacts the brain's control of appetite and metabolism.

Pathways

PRCP integrates into the renin-angiotensin-aldosterone system (RAAS) and the kallikrein-kinin system. In the RAAS PRCP influences angiotensin II levels which affects vasoconstriction and blood pressure. It has interactions with proteins such as angiotensin-converting enzyme (ACE) within these pathways enhancing its role in vascular biology and fluid balance.

An abnormal activity of PRCP links to hypertension and obesity. Hypertension connects to its activity on the RAAS pathway where it modulates angiotensin II influencing blood vessel constriction. In obesity altered PRCP activity affects neuropeptides in the brain impacting appetite and energy balance. PRCP's modulation of these systems makes it a potential target for therapeutic interventions in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity).
See full target information Lysosomal Pro-X carboxypeptidase
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical investigation 131: PubMed34499625

2021

Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongyang Zhang,Zeguo Sun,Jia Fu,Qisheng Lin,Khadija Banu,Kinsuk Chauhan,Marina Planoutene,Chengguo Wei,Fadi Salem,Zhengzi Yi,Ruijie Liu,Paolo Cravedi,Haoxiang Cheng,Ke Hao,Philip J O'Connell,Shuta Ishibe,Weijia Zhang,Steven G Coca,Ian W Gibson,Robert B Colvin,John Cijiang He,Peter S Heeger,Barbara Murphy,Madhav C Menon
View all publications
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Product promise

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