Anti-PRDM13 antibody - N-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

PRDM13 often referred to as PR domain containing 13 plays an important role in the regulation of gene expression through its action as a transcriptional repressor. It acts by binding to specific regions of DNA and modifying chromatin structure to suppress or silence gene activity. PRDM13 with its molecular mass of approximately 45 kDa is predominantly expressed in the developing neural tissue particularly during early embryogenesis. Its expression is also detected in certain adult tissues but to a lesser extent.

Biological function summary

This protein contributes to the establishment of neuronal identity and differentiation. PRDM13 often operates as a part of larger protein complexes that are involved in transcriptional repression. By interacting with other proteins it fine-tunes gene expression to ensure proper development of the central nervous system. Its precise regulation during critical windows of embryonic development suggests it molds the fate of progenitor cells into specific neuronal lineages highlighting its significance in neural patterning.

Pathways

PRDM13 plays an essential role in the Notch signaling pathway which is instrumental in maintaining the balance between proliferation and differentiation in neural progenitor cells. It strategically regulates this path in cooperation with other related proteins like Hes1 and Sox2. PRDM13 indirectly influences the activity of involved genes ensuring that the cellular responses are appropriate for developmental stages. This modulation can ensure the correct morphological and functional development of the nervous system.

Associated diseases and disorders

Aberrant expression or mutation of PRDM13 associates with neurodevelopmental disorders such as intellectual disability and related cognitive impairments. PRDM13's connection to diseases stems from its interactions with proteins like NOTCH1 as disruptions in these pathways may lead to improper neuronal differentiation and development. Ongoing research aims to decipher its exact role and how its dysfunction contributes to these conditions paving the way for potential therapeutic interventions.