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AB69206

Anti-PRDM15 antibody

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(2 Publications)

Mouse Polyclonal PRDM15 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PRDM15.

View Alternative Names

C21orf83, ZNF298, PRDM15, PR domain zinc finger protein 15, PR domain-containing protein 15, Zinc finger protein 298

1 Images
Immunocytochemistry/ Immunofluorescence - Anti-PRDM15 antibody (AB69206)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PRDM15 antibody (AB69206)

ab69206 at 10µg/ml staining PRDM15 in human Hela cells by ICC/IF.

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human PRDM15.

P57071

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PRDM15 also known as PR Domain Zinc Finger Protein 15 functions as a transcriptional regulator with a zinc finger domain. It influences gene expression through epigenetic modifications. The protein has a mass of approximately 97 kDa. Research shows that PRDM15 is expressed in pluripotent stem cells and certain tissues during early developmental stages playing a role in maintaining cellular identity.
Biological function summary

The protein participates in regulating stem cell pluripotency and differentiation. PRDM15 forms part of transcriptional complexes that modulate the expression of important developmental genes. It ensures the correct activation of target genes allowing for proper cellular function and development. Researchers have found it maintains a balance between pluripotency and differentiation during embryogenesis affecting various developmental processes.

Pathways

PRDM15 acts within the Wnt signaling pathway and also influences the Hedgehog pathway. These pathways are significant for cell differentiation and developmental processes. The protein works closely with other transcription factors such as TCF/LEF in the Wnt pathway impacting gene regulation. PRDM15 modulates the expression of pathway-specific genes linking it to several important cellular functions.

PRDM15's dysfunction associates with congenital malformations and cancer. Mutations in PRDM15 can lead to an increased risk of certain developmental disorders due to its role in embryogenesis. There is also evidence connecting PRDM15 to tumorigenesis where its dysregulation may contribute to oncogenic processes. Researchers have observed interactions with proteins like GLI1 in the context of cancer highlighting its potential role in disease pathogenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Also plays a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed : 28740264).
See full target information PRDM15
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

PLoS biology 20:e3001554 PubMed36026478

2022

The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Katie J Smith,Danielle Minns,Brian J McHugh,Rebecca K Holloway,Richard O'Connor,Anna Williams,Lauren Melrose,Rhoanne McPherson,Veronique E Miron,Donald J Davidson,Emily Gwyer Findlay

Journal of the American Society of Nephrology : JASN 32:580-596 PubMed33593823

2021

Mutations in Are a Novel Cause of Galloway-Mowat Syndrome.

Applications

Unspecified application

Species

Unspecified reactive species

Nina Mann,Slim Mzoughi,Ronen Schneider,Susanne J Kühl,Denny Schanze,Verena Klämbt,Svjetlana Lovric,Youying Mao,Shasha Shi,Weizhen Tan,Michael Kühl,Ana C Onuchic-Whitford,Ernestine Treimer,Thomas M Kitzler,Franziska Kause,Sven Schumann,Makiko Nakayama,Florian Buerger,Shirlee Shril,Amelie T van der Ven,Amar J Majmundar,Kristina Marie Holton,Amy Kolb,Daniela A Braun,Jia Rao,Tilman Jobst-Schwan,Eva Mildenberger,Thomas Lennert,Alma Kuechler,Dagmar Wieczorek,Oliver Gross,Beate Ermisch-Omran,Anja Werberger,Martin Skalej,Andreas R Janecke,Neveen A Soliman,Shrikant M Mane,Richard P Lifton,Jan Kadlec,Ernesto Guccione,Michael J Schmeisser,Martin Zenker,Friedhelm Hildebrandt
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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