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AB204997

Anti-Prealbumin antibody [2E10C5]

5

(1 Review)

|

(2 Publications)

Mouse Monoclonal Prealbumin antibody. Suitable for Flow Cyt, WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human TTR.

View Alternative Names

PALB, TTR, Transthyretin, ATTR, Prealbumin, TBPA

6 Images
Immunocytochemistry/ Immunofluorescence - Anti-Prealbumin antibody [2E10C5] (AB204997)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Prealbumin antibody [2E10C5] (AB204997)

Immunofluorescence analysis of A549 cells labeling Prealbumin with ab204997 at a 1/200 dilution (green), followed by Alexa Fluor® 555 phalloidin (red). Nuclear counterstain DRAQ5 fluorescent DNA dye used (blue).

Flow Cytometry - Anti-Prealbumin antibody [2E10C5] (AB204997)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-Prealbumin antibody [2E10C5] (AB204997)

Flow cytometric analysis of A549 cells labelling Prealbumin with ab204997 (green) at a 1/200 dilution and negative control (red).

Immunocytochemistry/ Immunofluorescence - Anti-Prealbumin antibody [2E10C5] (AB204997)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Prealbumin antibody [2E10C5] (AB204997)

Immunofluorescence analysis of MCF-7 cells labeling Prealbumin with ab204997 at a 1/200 dilution (green), followed by Alexa Fluor® 555 phalloidin (red). Nuclear counterstain DRAQ5 fluorescent DNA dye used (blue).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prealbumin antibody [2E10C5] (AB204997)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prealbumin antibody [2E10C5] (AB204997)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded section) analysis of Human liver cancer tissue labeling Prealbumin with ab204997 at a 1/200 dilution. DAB staining used.

Western blot - Anti-Prealbumin antibody [2E10C5] (AB204997)
  • WB

Supplier Data

Western blot - Anti-Prealbumin antibody [2E10C5] (AB204997)

All lanes:

Western blot - Anti-Prealbumin antibody [2E10C5] (ab204997) at 1/500 dilution

All lanes:

Human Prealbumin (aa1-147) recombinant protein

Predicted band size: 15 kDa

Observed band size: 45.8 kDa

false

Western blot - Anti-Prealbumin antibody [2E10C5] (AB204997)
  • WB

Supplier Data

Western blot - Anti-Prealbumin antibody [2E10C5] (AB204997)

All lanes:

Western blot - Anti-Prealbumin antibody [2E10C5] (ab204997) at 1/500 dilution

Lane 1:

HEK293 whole cell lysate

Lane 2:

Prealbumin (aa1-147)-hIgGFc transfected HEK293 whole cell lysate

Predicted band size: 15 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

2E10C5

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P, WB, Flow Cyt

applications

Immunogen

Recombinant Full Length Protein corresponding to Human TTR.

P02766

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/200 - 1/400", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/1000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/200 - 1/1000", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purified from tissue culture supernatant.
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prealbumin also known as transthyretin is a protein with a molecular mass of approximately 55 kDa. The liver primarily synthesizes prealbumin and it is present in the bloodstream. Functionally prealbumin transports thyroxine and retinol-binding protein-retinol complex facilitating the distribution of these molecules to target tissues. As such it plays an integral role in maintaining retinol and thyroid hormone homeostasis.
Biological function summary

Prealbumin interacts with retinol-binding protein to form a complex essential for vitamin A transportation. This complex prevents renal filtration of retinol-binding protein thereby conserving vitamin A in circulation. The protein's role extends beyond transport as it influences neurophysiological processes due to its ability to bind thyroid hormones and affect gene expression related to metabolism. Prealbumin is primarily a part of the thyroxine-transferring complex reinforcing its critical position in hormonal and vitamin dynamics.

Pathways

Prealbumin's role in the thyroxine-binding globulin pathway highlights its importance in the endocrine system. Another pathway where prealbumin contributes significantly is the vitamin A metabolic pathway. In these pathways prealbumin maintains functional relationships with proteins like retinol-binding protein and thyroxine-binding globulin which jointly modulate thyroid hormone transport and vitamin A dynamics across cellular membranes.

Prealbumin directly associates with familial amyloid polyneuropathy and malnutrition. Familial amyloid polyneuropathy involves the deposition of prealbumin-derived amyloid fibrils in peripheral nerves impacting neuron function. In malnutrition decreased prealbumin levels serve as a biomarker reflecting poor nutritional status. Clinically prealbumin's relation to retinol-binding protein and thyroid hormone levels facilitates its use in diagnosing and monitoring these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
See full target information TTR
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in immunology 16:1577781 PubMed40534859

2025

Integrated machine learning and single-cell analysis reveal the prognostic and therapeutic potential of SUMOylation-related genes in ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengrong Deng,Yicong Xu,Peidong Zhang,Yixiang Peng,Jiaxing Tan,Zihang Chen,Yimei Ma

Drug testing and analysis 14:80-91 PubMed34397154

2021

Transthyretin as a target of alkylation and a potential biomarker for sulfur mustard poisoning: Electrophoretic and mass spectrometric identification and characterization.

Applications

Unspecified application

Species

Unspecified reactive species

Wolfgang Schmeißer,Robin Lüling,Dirk Steinritz,Horst Thiermann,Theo Rein,Harald John
View all publications
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Product promise

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