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AB244716

Anti-Prealbumin antibody [EPR20073-79] - BSA and Azide free (Capture)

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Anti-Prealbumin antibody [EPR20073-79] - BSA and Azide free (Capture) (ab244716) is a rabbit recombinant monoclonal antibody provided in a PBS only buffer for easy conjugation detecting Prealbumin in ELISA. Suitable for Human.

- Effortless conjugation workflows: free from BSA, sodium azide, and glycerol
- Consistent performance across batches: ensured by rigorous biophysical quality control
- Pre-screened with matching detector antibody: Anti-Prealbumin antibody [EPR20073-79] - BSA and Azide free (Capture) (ab244983)

View Alternative Names

PALB, TTR, Transthyretin, ATTR, Prealbumin, TBPA

1 Images
Sandwich ELISA - Anti-Prealbumin antibody [EPR20073-79] - BSA and Azide free (Capture) (AB244716)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-Prealbumin antibody [EPR20073-79] - BSA and Azide free (Capture) (AB244716)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab231920).

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR20073-79

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Product details

Product Specifications
Anti-Prealbumin antibody [EPR20073-79] - BSA and Azide free (Capture) (ab244716) is a recombinant rabbit monoclonal antibody which was developed by Abcam using patented rabbit monoclonal antibody technology.
ab244716 is provided in a carrier-free, conjugation ready format, and is validated in sELISAin human samples.
Carrier-free antibodies are compatible with our best-in-class range of Lightning-Link® conjugation kits.
Anti-Prealbumin antibody [EPR20073-79] - BSA and Azide free (Capture) (ab244716) specifically detects Prealbumin (UniProt ID: P02766; Molecular weight: 14kDa) and is sold in 100 ug and 1mg selling sizes.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prealbumin also known as transthyretin is a protein with a molecular mass of approximately 55 kDa. The liver primarily synthesizes prealbumin and it is present in the bloodstream. Functionally prealbumin transports thyroxine and retinol-binding protein-retinol complex facilitating the distribution of these molecules to target tissues. As such it plays an integral role in maintaining retinol and thyroid hormone homeostasis.
Biological function summary

Prealbumin interacts with retinol-binding protein to form a complex essential for vitamin A transportation. This complex prevents renal filtration of retinol-binding protein thereby conserving vitamin A in circulation. The protein's role extends beyond transport as it influences neurophysiological processes due to its ability to bind thyroid hormones and affect gene expression related to metabolism. Prealbumin is primarily a part of the thyroxine-transferring complex reinforcing its critical position in hormonal and vitamin dynamics.

Pathways

Prealbumin's role in the thyroxine-binding globulin pathway highlights its importance in the endocrine system. Another pathway where prealbumin contributes significantly is the vitamin A metabolic pathway. In these pathways prealbumin maintains functional relationships with proteins like retinol-binding protein and thyroxine-binding globulin which jointly modulate thyroid hormone transport and vitamin A dynamics across cellular membranes.

Prealbumin directly associates with familial amyloid polyneuropathy and malnutrition. Familial amyloid polyneuropathy involves the deposition of prealbumin-derived amyloid fibrils in peripheral nerves impacting neuron function. In malnutrition decreased prealbumin levels serve as a biomarker reflecting poor nutritional status. Clinically prealbumin's relation to retinol-binding protein and thyroid hormone levels facilitates its use in diagnosing and monitoring these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
See full target information TTR
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Product promise

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