JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB196275

Anti-PRELID1 antibody

5

(1 Review)

|

(2 Publications)

Rabbit Polyclonal PRELID1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PRELID1 aa 50-200.

View Alternative Names

PRELI, CGI-106, SBBI12, PRELID1, 25 kDa protein of relevant evolutionary and lymphoid interest, Px19-like protein

1 Images
Western blot - Anti-PRELID1 antibody (AB196275)
  • WB

Supplier Data

Western blot - Anti-PRELID1 antibody (AB196275)

All lanes:

Western blot - Anti-PRELID1 antibody (ab196275) at 1/500 dilution

All lanes:

K562 cell lysate

Predicted band size: 25 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human PRELID1 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q9Y255

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
Preservative: 0.02% Sodium azide Constituents: 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PRELID1 also known as SLMO2 is a mitochondrial phospholipid transfer protein. This protein has a molecular mass of approximately 22 kDa and is expressed in various tissues with notable presence in the liver heart and skeletal muscle. Mechanically PRELID1 transfers phosphatidic acid from the outer to the inner mitochondrial membrane a process fundamental for maintaining mitochondrial lipid homeostasis.
Biological function summary

PRELID1 operates as part of a larger multi-protein complex within the mitochondria. It associates with other proteins like TRIT1 which together play a role in lipid metabolism and regulation. PRELID1's actions impact the synthesis of cardiolipin a critical lipid for mitochondrial inner membrane structure and function. By participating in these processes PRELID1 ensures proper mitochondrial activity and energy production.

Pathways

The activity of PRELID1 intersects with key pathways involved in lipid metabolism and mitochondrial function. Notably it plays a role in the CL (cardiolipin) remodeling pathway. Furthermore PRELID1 interacts with proteins such as TAMM41 a phosphatidic acid transfer protein which facilitates cardiolipin biosynthesis. These pathways are essential for the maintenance of mitochondrial membrane potential and cellular energy output.

Abnormalities in PRELID1 function connect to mitochondrial-related diseases including Barth syndrome and certain metabolic disorders. Research indicates its malfunction could link to altered cardiolipin synthesis affecting energy metabolism. Proteins involved in these conditions such as tafazzin play a role in cardiolipin remodeling highlighting the importance of PRELID1's function in maintaining healthy mitochondrial dynamics.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1 : PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.
See full target information PRELID1
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of molecular and cellular cardiology 167:1-14 PubMed35304170

2022

EFHD1 ablation inhibits cardiac mitoflash activation and protects cardiomyocytes from ischemia.

Applications

Unspecified application

Species

Unspecified reactive species

David R Eberhardt,Sandra H Lee,Xue Yin,Anthony M Balynas,Emma C Rekate,Jackie N Kraiss,Marisa J Lang,Maureen A Walsh,Molly E Streiff,Andrea C Corbin,Ying Li,Katsuhiko Funai,Frank B Sachse,Dipayan Chaudhuri

Translational oncology 11:786-793 PubMed29702465

2018

GALNT14 Involves the Regulation of Multidrug Resistance in Breast Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jinshuai Shan,Yang Liu,Yukun Wang,Yimiao Li,Xiaochun Yu,Chen Wu
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB197123

Anti-GINS2 antibody

Western blot - Anti-GINS2 antibody (AB197123)

  • 0
  • 0
Primary Antibodies

AB92547

Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Multiplex immunohistochemistry - Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker (AB92547)

  • 5
  • 92
Primary Antibodies

AB193624

Anti-WWOX (phospho Y33) antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-WWOX (phospho Y33) antibody (AB193624)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com