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AB229719

Anti-PRELP antibody

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(3 Publications)

Rabbit Polyclonal PRELP antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PRELP.

View Alternative Names

SLRR2A, PRELP, Prolargin, Proline-arginine-rich end leucine-rich repeat protein

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRELP antibody (AB229719)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRELP antibody (AB229719)

Paraffin-embedded mouse kidney tissue stained for PRELP using ab229719 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRELP antibody (AB229719)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRELP antibody (AB229719)

Paraffin-embedded mouse prostate tissue stained for PRELP using ab229719 at 1/500 dilution in immunohistochemical analysis.

Western blot - Anti-PRELP antibody (AB229719)
  • WB

Supplier Data

Western blot - Anti-PRELP antibody (AB229719)

10% SDS-PAGE gel.

All lanes:

Western blot - Anti-PRELP antibody (ab229719) at 1/500 dilution

All lanes:

Mouse heart tissue extract at 50 µg

Predicted band size: 44 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human PRELP. The exact immunogen used to generate this antibody is proprietary information.

P51888

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Primary Antibodies

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Secondary Antibodies

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Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

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Primary Antibodies

AB15251

Anti-Wnt1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Wnt1 antibody (AB15251)

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  • 8
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PRELP also known as proline/arginine-rich end leucine-rich repeat protein is a member of the leucine-rich repeat protein family. It has a molecular weight of approximately 48 kDa. This protein is expressed in connective tissues such as cartilage and tendons. PRELP interacts with many components of the extracellular matrix including biglycan and decorin contributing to the structural organization of these tissues.
Biological function summary

PRELP plays a role in maintaining the integrity of the extracellular matrix by acting as a bridge between fibrous collagens and basement membranes. It is not part of any well-defined complex but its ability to bind to both collagen and basement membrane components is essential for tissue stabilization. PRELP's interaction with heparan sulfate proteoglycans contributes to its function in tissue maintenance and integrity.

Pathways

Some pathways are affected by PRELP's interaction with the extracellular matrix components. PRELP is part of the extracellular matrix organization pathway and can influence collagen fibril formation. Its relationship with fibromodulin and lumican through extracellular interactions suggests its role in the stabilization and assembly of collagen fibrils and overall matrix regulation.

A connection exists between PRELP and conditions involving compromised connective tissues such as osteoarthritis and Ehlers-Danlos syndrome. In these cases altered interaction of PRELP with collagen and extracellular matrix components contributes to disease pathogenesis. The protein's linkage to decorin and fibromodulin further highlights its role in diseases affecting the structural integrity of connective tissues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May anchor basement membranes to the underlying connective tissue.
See full target information PRELP
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in genetics 16:1615259 PubMed41031085

2025

Characterization of the phenotype and function of PRELP fibroblast subtype in liver metastatic colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yuting Dai,Xingying Huang,Min Sun,Shiyu Zhang,Weiqiang Yu,Kongwang Hu,Qiang Wu,Qingfa Wu

Cardiovascular journal of Africa 33:228-233 PubMed35788244

2022

PRELP promotes myocardial fibrosis and ventricular remodelling after acute myocardial infarction by the wnt/β-catenin signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Zhang,Chunli Fu,Shaohua Zhao,Honglei Jiang,Wei Li,Xiangju Liu

Journal of cellular and molecular medicine 23:6822-6834 PubMed31386303

2019

Molecular mechanism of tumour necrosis factor alpha regulates hypocretin (orexin) expression, sleep and behaviour.

Applications

Unspecified application

Species

Unspecified reactive species

Shuqin Zhan,Pulin Che,Xue-Ke Zhao,Ning Li,Yan Ding,Jianghong Liu,Spring Li,Karyn Ding,Lynn Han,Zhaoyang Huang,Liyong Wu,Yuping Wang,Meng Hu,Xiaosi Han,Qiang Ding
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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