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AB122523

Anti-PRHOXNB antibody

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(1 Publication)

Rabbit Polyclonal PRHOXNB antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human URAD aa 1-100.

View Alternative Names

PRHOXNB, URAD, Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, OHCU decarboxylase, Parahox neighbor, Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRHOXNB antibody (AB122523)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PRHOXNB antibody (AB122523)

ab122523 at 1/850 dilution staining PRHOXNB in Paraffin-embedded Human small intestine tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-PRHOXNB antibody (AB122523)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-PRHOXNB antibody (AB122523)

Immunofluorescent staining of Human cell line U-251 MG shows positivity in plasma membrane and cytoplasm. Recommended concentration of ab122523 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human URAD aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

A6NGE7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/850", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Recommend PFA Fixation and Triton X-100 treatment</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PRHOXNB also known as paired related homeobox protein NB is a cellular protein functioning in transcriptional regulation. It has a molecular mass of approximately 32 kDa. The expression of PRHOXNB occurs predominantly in the central nervous system and some peripheral tissues. It serves an essential role in the transcription regulation by interacting with specific DNA sequences influencing gene expression.
Biological function summary

PRHOXNB influences neuronal differentiation and development. It functions as part of a larger transcriptional complex. PRHOXNB contributes to the determination of cell fate during neural development. By interacting with other transcription factors it modulates the activity of genes involved in neural cell differentiation promoting normal brain development and function.

Pathways

PRHOXNB is involved in the Wnt signaling pathway and neural development pathways. Its interactions within the Wnt signaling pathway help regulate neural patterning and synaptogenesis. PRHOXNB often cooperates with proteins like β-catenin within these pathways contributing to the regulation of target gene expression. These interactions ensure proper neural tissue development and maintenance.

PRHOXNB has been linked to neurodevelopmental disorders and certain types of cancer. Altered expression or mutations in PRHOXNB may contribute to neural developmental issues such as autism spectrum disorders. Additionally its abnormal activity has been observed in certain cancers where it might interact with proteins like p53 impacting cell cycle regulation and leading to tumorigenesis.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.
See full target information URAD
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature genetics 48:367-73 PubMed26878724

2016

NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Takaya Moriyama,Rina Nishii,Virginia Perez-Andreu,Wenjian Yang,Federico Antillon Klussmann,Xujie Zhao,Ting-Nien Lin,Keito Hoshitsuki,Jacob Nersting,Kentaro Kihira,Ute Hofmann,Yoshihiro Komada,Motohiro Kato,Robert McCorkle,Lie Li,Katsuyoshi Koh,Cesar Rolando Najera,Shirley Kow-Yin Kham,Tomoya Isobe,Zhiwei Chen,Edwynn Kean-Hui Chiew,Deepa Bhojwani,Cynthia Jeffries,Yan Lu,Matthias Schwab,Hiroto Inaba,Ching-Hon Pui,Mary V Relling,Atsushi Manabe,Hiroki Hori,Kjeld Schmiegelow,Allen E J Yeoh,William E Evans,Jun J Yang
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

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