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Proteins and peptidesAnti-Ly6g antibody [1A8] - mouse IgG2c (Chimeric)
Low endotoxin, Azide free.
Our first-to-market chimera with mouse IgG2c backbone, this functional antibody specifically depletes neutrophils in vivo for up to 72h.
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Mouse Monoclonal Prion protein PrP antibody. Suitable for ICC, IP, Flow Cyt, WB, IHC-P, I-ELISA and reacts with Mouse, Rat, Monkey, Human, Cow, Sheep samples. Cited in 13 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Prnp.
IgG2b
Mouse
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS
Liquid
Monoclonal
ICC | IP | Flow Cyt | WB | IHC-P | I-ELISA | |
---|---|---|---|---|---|---|
Human | Expected | Expected | Expected | Predicted | Expected | Expected |
Mouse | Expected | Expected | Expected | Tested | Expected | Expected |
Rat | Expected | Expected | Expected | Predicted | Expected | Expected |
Cow | Expected | Expected | Expected | Predicted | Expected | Expected |
Monkey | Expected | Expected | Expected | Predicted | Expected | Expected |
Sheep | Expected | Expected | Expected | Predicted | Expected | Expected |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat, Monkey, Human, Cow, Sheep | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat, Monkey, Human, Cow, Sheep | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info - | Notes ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Species Rat | Dilution info - | Notes ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Species Monkey | Dilution info - | Notes ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Species Human | Dilution info - | Notes ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Species Cow | Dilution info - | Notes ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Species Sheep | Dilution info - | Notes ab170192 - Mouse monoclonal IgG2b, is suitable for use as an isotype control with this antibody. |
Species | Dilution info | Notes |
---|---|---|
Species Mouse | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Sheep, Monkey, Human, Cow, Rat | Dilution info - | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat, Monkey, Human, Cow, Sheep | Dilution info Use at an assay dependent concentration. | Notes - |
Species | Dilution info | Notes |
---|---|---|
Species Mouse, Rat, Monkey, Human, Cow, Sheep | Dilution info Use at an assay dependent concentration. | Notes - |
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
Major prion protein, PrP, ASCR, PrP27-30, PrP33-35C, PRP, ALTPRP, PRNP, PRIP
Mouse Monoclonal Prion protein PrP antibody. Suitable for ICC, IP, Flow Cyt, WB, IHC-P, I-ELISA and reacts with Mouse, Rat, Monkey, Human, Cow, Sheep samples. Cited in 13 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Prnp.
Major prion protein, PrP, ASCR, PrP27-30, PrP33-35C, PRP, ALTPRP, PRNP, PRIP
IgG2b
Mouse
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: 0.0268% PBS
Liquid
Monoclonal
8H4
IgG fraction
The antibody epitope resides within amino acids 145-180 of human Prion protein PrP.
Purified Immunoglobulin
Blue Ice
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Prion protein assists in maintaining normal cell activities. Researchers do not fully understand its exact biological role but it might be involved in copper ion uptake and protection against oxidative stress. PrP can form complexes with other cellular proteins some of which help in routing signals inside the cell. Additionally prion protein may have synaptic functions related to neurodevelopment and neuroprotection.
Prion protein also known as PrP or major prion protein plays a mechanical role in the normal functioning of brain cells. It is a glycoprotein with a flexible structure and has an approximate mass of 35-36 kDa. PrP expression is high in nervous tissue. It is present in neurons and glial cells but also surfaces in other tissues like heart and kidney. Alternate names like p-pr-p and f89 refer to specific conformations or studies related to its structure.
Prion protein links to both neuroprotective and neurodegenerative pathways. It participates in signaling pathways that protect neurons from apoptosis. This protein associates closely with copper-dependent pathways possibly related to its capacity to bind copper ions which affects oxidative stress responses. Prion protein also interacts with proteins like synapsin to modulate synaptic transmission.
Prion protein is directly related to prion diseases such as Creutzfeldt-Jakob disease and kuru. These diseases arise from misfolded forms of PrP which aggregate and cause neurodegeneration. The misfolded form referred to as PrP^Sc can induce normal PrP to misfold propagating disease. Dopamine receptor proteins and synaptic proteins can indirectly interact or be affected in these disorders highlighting a complex network of affected neural functions.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
All lanes: Western blot - Anti-Prion protein PrP antibody [8H4] (AB61409) at 4 µg/mL
All lanes: Mouse brain extract
All lanes: Goat Anti-Mouse IgG-Peroxidase
Predicted band size: 28 kDa
All lanes: Western blot - Anti-Prion protein PrP antibody [8H4] (AB61409) at 1/2500 dilution
Lane 1: Wild type mouse hippocampus whole tissue lysate at 30 µg
Lane 2: Prnp-/- mouse hippocampus whole tissue lysate at 30 µg
All lanes: HRP-conjugated sheep anti-mouse IgG monoclonal at 1/5000 dilution
Developed using the ECL technique.
Performed under reducing conditions.
Predicted band size: 28 kDa
Observed band size: 25-37 kDa
Exposure time: 30s
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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