AB179822

Anti-PRMT7 antibody [EPR13489] - N-terminal

RabMAb
Recombinant
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(5 Publications)

Rabbit Recombinant Monoclonal PRMT7 antibody. N-terminal. Suitable for WB and reacts with Human samples. Cited in 5 publications.

View Alternative Names

KIAA1933, PRMT7, Protein arginine N-methyltransferase 7, Histone-arginine N-methyltransferase PRMT7, [Myelin basic protein]-arginine N-methyltransferase PRMT7

1 Images

Supplier Data

Western blot - Anti-PRMT7 antibody [EPR13489] - N-terminal (AB179822)

All lanes:

Western blot - Anti-PRMT7 antibody [EPR13489] - N-terminal (ab179822) at 1/1000 dilution

Lane 1:

HeLa cell lysate at 10 µg

Lane 2:

293T cell lysate at 10 µg

Lane 3:

HepG2 cell lysate at 10 µg

Lane 4:

MCF-7 cell lysate at 10 µg

Predicted band size: 78 kDa

false

Carrier free

Anti-PRMT7 antibody [EPR13489] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR13489

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Product details

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PRMT7 short for Protein Arginine Methyltransferase 7 plays an important role in the methylation of arginine residues on target proteins. It acts as a type of enzyme known for catalyzing the transfer of methyl groups. PRMT7 appears in several tissues although its expression is noted in higher amounts in brain and testis tissues. This protein weighs approximately 78 kDa and undergoes different modifications influencing its activity and localization. Researchers sometimes refer to PRMT7 simply as PRMT-7.

Biological function summary

The activity of this protein regulates gene expression by modifying histones and non-histone proteins affecting chromatin structure. It does not typically act as part of a large complex but can associate with other proteins to achieve specific functions. PRMT7 influences processes like protein signaling RNA processing and cell cycle control illustrating its diverse roles in cellular biology.

Pathways

PRMT7 participates intricately in pathways involving transcriptional regulation. It regulates pathways such as the arginine methylation pathway and is connected to transcription factor binding pathways. Its action intertwines with other methyltransferases and specific epigenetic regulators such as PRMT5 highlighting the crosstalk between different protein modification pathways within cells.

PRMT7 has a connection to cancer and neurodevelopmental disorders. Altered expression or activity of PRMT7 associates with oncogenesis making it a potential target in cancer research with some studies pointing out possible links to breast cancer. In neurodevelopmental disorders the protein's role in gene expression regulation suggests its involvement. In such conditions interactions with proteins such as FMR1 linked to Fragile X syndrome highlight the importance of understanding PRMT7's function to unravel its therapeutic implications.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.

See full target information PRMT7

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:8642 PubMed41028719

2025

Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Meixia Guo,Zheng Yuan,Xiong Jin,Xinyu Li,Yilin Deng,Shuchang Zhou,Rui Niu,Joonbeom Bae,Jong Bae Park,Bingyang Shi,Jinlong Yin

Experimental & molecular medicine 56:711-720 PubMed38486105

2024

Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Byeong-Yun Ahn,Yan Zhang,Shibo Wei,Yideul Jeong,Dong-Hyun Park,Sang-Jin Lee,Young-Eun Leem,Jong-Sun Kang

International journal of molecular sciences 23: PubMed36293180

2022

PRMT7 Inhibitor SGC8158 Enhances Doxorubicin-Induced DNA Damage and Its Cytotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Ahyeon Jeong,Yena Cho,Minkyeong Cho,Gyu-Un Bae,Dae-Geun Song,Su-Nam Kim,Yong Kee Kim

Nature communications 13:1232 PubMed35264579

2022

An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Shen,Ting Ni,Jiaxuan Chen,Haitao Chen,Xiaopin Ma,Guangwen Cao,Tianzhi Wu,Haisheng Xie,Bin Zhou,Gang Wei,Hexige Saiyin,Suqin Shen,Peng Yu,Qianyi Xiao,Hui Liu,Yuzheng Gao,Xidai Long,Jianhua Yin,Yanfang Guo,Jiaxue Wu,Gong-Hong Wei,Jinlin Hou,De-Ke Jiang

Nature communications 11:2396 PubMed32409666

2020

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.

Applications

Unspecified application

Species

Unspecified reactive species

Magdalena M Szewczyk,Yoshinori Ishikawa,Shawna Organ,Nozomu Sakai,Fengling Li,Levon Halabelian,Suzanne Ackloo,Amber L Couzens,Mohammad Eram,David Dilworth,Hideto Fukushi,Rachel Harding,Carlo C Dela Seña,Tsukasa Sugo,Kozo Hayashi,David McLeod,Carlos Zepeda,Ahmed Aman,Maria Sánchez-Osuna,Eric Bonneil,Shinji Takagi,Rima Al-Awar,Mike Tyers,Stephane Richard,Masayuki Takizawa,Anne-Claude Gingras,Cheryl H Arrowsmith,Masoud Vedadi,Peter J Brown,Hiroshi Nara,Dalia Barsyte-Lovejoy

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-PRMT7 antibody [EPR13489] - N-terminal

Western blot - Anti-PRMT7 antibody [EPR13489] - N-terminal (AB179822)

Related conjugates and formulations (1)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Product promise