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AB181214

Anti-PRMT7 antibody [EPR13495]

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(7 Publications)

Rabbit Recombinant Monoclonal PRMT7 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 7 publications.

View Alternative Names

KIAA1933, PRMT7, Protein arginine N-methyltransferase 7, Histone-arginine N-methyltransferase PRMT7, [Myelin basic protein]-arginine N-methyltransferase PRMT7

1 Images
Western blot - Anti-PRMT7 antibody [EPR13495] (AB181214)
  • WB

Supplier Data

Western blot - Anti-PRMT7 antibody [EPR13495] (AB181214)

All lanes:

Western blot - Anti-PRMT7 antibody [EPR13495] (ab181214) at 1/2000 dilution

Lane 1:

HepG2 cell lysate at 20 µg

Lane 2:

HeLa cell lysate at 20 µg

Lane 3:

293 cell lysate at 20 µg

Lane 4:

MCF7 cell lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 78 kDa

false

  • Carrier free

    Anti-PRMT7 antibody [EPR13495] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR13495

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/250", "ICCIF-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purity
Tissue culture supernatant
Storage buffer
Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PRMT7 short for Protein Arginine Methyltransferase 7 plays an important role in the methylation of arginine residues on target proteins. It acts as a type of enzyme known for catalyzing the transfer of methyl groups. PRMT7 appears in several tissues although its expression is noted in higher amounts in brain and testis tissues. This protein weighs approximately 78 kDa and undergoes different modifications influencing its activity and localization. Researchers sometimes refer to PRMT7 simply as PRMT-7.
Biological function summary

The activity of this protein regulates gene expression by modifying histones and non-histone proteins affecting chromatin structure. It does not typically act as part of a large complex but can associate with other proteins to achieve specific functions. PRMT7 influences processes like protein signaling RNA processing and cell cycle control illustrating its diverse roles in cellular biology.

Pathways

PRMT7 participates intricately in pathways involving transcriptional regulation. It regulates pathways such as the arginine methylation pathway and is connected to transcription factor binding pathways. Its action intertwines with other methyltransferases and specific epigenetic regulators such as PRMT5 highlighting the crosstalk between different protein modification pathways within cells.

PRMT7 has a connection to cancer and neurodevelopmental disorders. Altered expression or activity of PRMT7 associates with oncogenesis making it a potential target in cancer research with some studies pointing out possible links to breast cancer. In neurodevelopmental disorders the protein's role in gene expression regulation suggests its involvement. In such conditions interactions with proteins such as FMR1 linked to Fragile X syndrome highlight the importance of understanding PRMT7's function to unravel its therapeutic implications.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
See full target information PRMT7
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 30:549 PubMed41050779

2025

Protein arginine methyltransferase 7 regulates the cell cycle and promotes the progression of prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hongyuan Wan,Hangshen Zhou,Jiandong Gui,Dongjie Yang,Rong Wang,Jiang Ni,Sheng Wu,Yan Qin,Qiaowei Qi,Lijie Zhu,Ninghan Feng,Yuanyuan Mi

Nature communications 15:7421 PubMed39198433

2024

IGF2BP3 promotes mRNA degradation through internal mG modification.

Applications

Unspecified application

Species

Unspecified reactive species

Chang Liu,Xiaoyang Dou,Yutao Zhao,Linda Zhang,Lisheng Zhang,Qing Dai,Jun Liu,Tong Wu,Yu Xiao,Chuan He

Cell death & disease 14:827 PubMed38092752

2023

Fasting regulates mitochondrial function through lncRNA PRKCQ-AS1-mediated IGF2BPs in papillary thyroid carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoping Zhang,Yong Zhong,Lin Liu,Chengyou Jia,Haidong Cai,Jianshe Yang,Bo Wu,Zhongwei Lv

International journal of molecular sciences 23: PubMed36293180

2022

PRMT7 Inhibitor SGC8158 Enhances Doxorubicin-Induced DNA Damage and Its Cytotoxicity.

Applications

Unspecified application

Species

Unspecified reactive species

Ahyeon Jeong,Yena Cho,Minkyeong Cho,Gyu-Un Bae,Dae-Geun Song,Su-Nam Kim,Yong Kee Kim

Nature communications 13:1232 PubMed35264579

2022

An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Shen,Ting Ni,Jiaxuan Chen,Haitao Chen,Xiaopin Ma,Guangwen Cao,Tianzhi Wu,Haisheng Xie,Bin Zhou,Gang Wei,Hexige Saiyin,Suqin Shen,Peng Yu,Qianyi Xiao,Hui Liu,Yuzheng Gao,Xidai Long,Jianhua Yin,Yanfang Guo,Jiaxue Wu,Gong-Hong Wei,Jinlin Hou,De-Ke Jiang

Acta biochimica et biophysica Sinica 53:925-932 PubMed34041522

2021

The role of protein arginine methyltransferase 7 in human developmentally arrested embryos cultured in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Wuwen Zhang,Shifeng Li,Kai Li,L I Li,Ping Yin,Guoqing Tong

Cell reports 32:108172 PubMed32997990

2020

Actin R256 Mono-methylation Is a Conserved Post-translational Modification Involved in Transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Ashok Kumar,Yuan Zhong,Amelie Albrecht,Pau Biak Sang,Adrian Maples,Zhenan Liu,Vinesh Vinayachandran,Rohit Reja,Chia-Fang Lee,Ashutosh Kumar,Jiyuan Chen,Jing Xiao,Bongsoo Park,Jianjun Shen,Bin Liu,Maria D Person,Kathleen M Trybus,Kam Y J Zhang,B Franklin Pugh,Kristine E Kamm,Dianna M Milewicz,Xuetong Shen,Prabodh Kapoor
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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