Rabbit Recombinant Monoclonal PRMT7 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications.
Images
![Western blot - Anti-PRMT7 antibody [EPR13495] (AB181214), expandable thumbnail](https://content.abcam.com/products/images/prmt7-antibody-epr13495-ab181214--western-blot-img111137.png/_jcr_content/renditions/webp-475.webp "Western blot - Anti-PRMT7 antibody [EPR13495] (AB181214)")
Publications
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- Cell death & disease 14:8272023Fasting regulates mitochondrial function through lncRNA PRKCQ-AS1-mediated IGF2BPs in papillary thyroid carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaoping Zhang,Yong Zhong,Lin Liu,Chengyou Jia,Haidong Cai,Jianshe Yang,Bo Wu,Zhongwei LvPubMed 38092752
- International journal of molecular sciences 23:2022PRMT7 Inhibitor SGC8158 Enhances Doxorubicin-Induced DNA Damage and Its Cytotoxicity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAhyeon Jeong,Yena Cho,Minkyeong Cho,Gyu-Un Bae,Dae-Geun Song,Su-Nam Kim,Yong Kee KimPubMed 36293180
- Nature communications 13:12322022An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTing Shen,Ting Ni,Jiaxuan Chen,Haitao Chen,Xiaopin Ma,Guangwen Cao,Tianzhi Wu,Haisheng Xie,Bin Zhou,Gang Wei,Hexige Saiyin,Suqin Shen,Peng Yu,Qianyi Xiao,Hui Liu,Yuzheng Gao,Xidai Long,Jianhua Yin,Yanfang Guo,Jiaxue Wu,Gong-Hong Wei,Jinlin Hou,De-Ke JiangPubMed 35264579
- Acta biochimica et biophysica Sinica 53:925-9322021The role of protein arginine methyltransferase 7 in human developmentally arrested embryos cultured in vitro.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWuwen Zhang,Shifeng Li,Kai Li,L I Li,Ping Yin,Guoqing TongPubMed 34041522
- Cell reports 32:1081722020Actin R256 Mono-methylation Is a Conserved Post-translational Modification Involved in Transcription.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAshok Kumar,Yuan Zhong,Amelie Albrecht,Pau Biak Sang,Adrian Maples,Zhenan Liu,Vinesh Vinayachandran,Rohit Reja,Chia-Fang Lee,Ashutosh Kumar,Jiyuan Chen,Jing Xiao,Bongsoo Park,Jianjun Shen,Bin Liu,Maria D Person,Kathleen M Trybus,Kam Y J Zhang,B Franklin Pugh,Kristine E Kamm,Dianna M Milewicz,Xuetong Shen,Prabodh KapoorPubMed 32997990
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000 - 1/10000 | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/250 | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.
Alternative names
KIAA1933, PRMT7, Protein arginine N-methyltransferase 7, Histone-arginine N-methyltransferase PRMT7, [Myelin basic protein]-arginine N-methyltransferase PRMT7
Recommended products
Rabbit Recombinant Monoclonal PRMT7 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.01% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- EPR13495
- Purity
- Tissue culture supernatant
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PRMT7 short for Protein Arginine Methyltransferase 7 plays an important role in the methylation of arginine residues on target proteins. It acts as a type of enzyme known for catalyzing the transfer of methyl groups. PRMT7 appears in several tissues although its expression is noted in higher amounts in brain and testis tissues. This protein weighs approximately 78 kDa and undergoes different modifications influencing its activity and localization. Researchers sometimes refer to PRMT7 simply as PRMT-7.
- Biological function summary
The activity of this protein regulates gene expression by modifying histones and non-histone proteins affecting chromatin structure. It does not typically act as part of a large complex but can associate with other proteins to achieve specific functions. PRMT7 influences processes like protein signaling RNA processing and cell cycle control illustrating its diverse roles in cellular biology.
- Pathways
PRMT7 participates intricately in pathways involving transcriptional regulation. It regulates pathways such as the arginine methylation pathway and is connected to transcription factor binding pathways. Its action intertwines with other methyltransferases and specific epigenetic regulators such as PRMT5 highlighting the crosstalk between different protein modification pathways within cells.
- Associated diseases and disorders
PRMT7 has a connection to cancer and neurodevelopmental disorders. Altered expression or activity of PRMT7 associates with oncogenesis making it a potential target in cancer research with some studies pointing out possible links to breast cancer. In neurodevelopmental disorders the protein's role in gene expression regulation suggests its involvement. In such conditions interactions with proteins such as FMR1 linked to Fragile X syndrome highlight the importance of understanding PRMT7's function to unravel its therapeutic implications.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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1 product image
![Western blot - Anti-PRMT7 antibody [EPR13495] (ab181214), expandable thumbnail](https://content.abcam.com/products/images/prmt7-antibody-epr13495-ab181214--western-blot-img111137.png "Western blot - Anti-PRMT7 antibody [EPR13495] (ab181214)")
Western blot - Anti-PRMT7 antibody [EPR13495] (ab181214)
All lanes: Western blot - Anti-PRMT7 antibody [EPR13495] (ab181214) at 1/2000 dilution
Lane 1: HepG2 cell lysate at 20 µg
Lane 2: HeLa cell lysate at 20 µg
Lane 3: 293 cell lysate at 20 µg
Lane 4: MCF7 cell lysate at 20 µg
SecondaryAll lanes: Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution
Predicted band size: 78 kDa
Downloads
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