Anti-pro Caspase-12 antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

Pro Caspase-12 involves itself in cellular stress responses especially ER stress-induced apoptosis. It integrates into complexes responsible for mediating cell death signals when ER function is compromised. Known for its function through interactions with other caspases pro Caspase-12 activates effector caspases like Caspase-3 and Caspase-7 which eventually lead to apoptotic cell death. The protein contributes significantly to maintaining homeostasis in response to perturbations within the ER environment.

Pathways

Pro Caspase-12 takes part in the unfolded protein response and ER stress pathways. These pathways are essential for managing misfolded proteins within the ER and preventing toxic aggregation. Through its activity in these pathways pro Caspase-12 connects with proteins such as CHOP a transcription factor that amplifies the apoptotic response under stress conditions and Caspase-9 which is involved in the intrinsic pathway of apoptosis. These interactions highlight its role in coordinating apoptosis triggered by severe ER stress.