Rabbit Recombinant Monoclonal Caspase-8 antibody. Suitable for WB, IHC-P and reacts with Rat, Mouse, Human samples. Cited in 34 publications.
Images
![Western blot - Anti-Pro Caspase-8 antibody [EPR162] (AB108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--western-blot-img155016.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Pro Caspase-8 antibody [EPR162] (AB108333)")
![Western blot - Anti-Pro Caspase-8 antibody [EPR162] (AB108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--western-blot-img4838.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Pro Caspase-8 antibody [EPR162] (AB108333)")
![Western blot - Anti-Pro Caspase-8 antibody [EPR162] (AB108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--western-blot-img163887.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Pro Caspase-8 antibody [EPR162] (AB108333)")
![Western blot - Anti-Pro Caspase-8 antibody [EPR162] (AB108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--western-blot-img115772.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Pro Caspase-8 antibody [EPR162] (AB108333)")
Publications
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- Advanced science (Weinheim, Baden-Wurttemberg, Germany) 10:e22063442023Loss of RPA1 Impairs Peripheral T Cell Homeostasis and Exacerbates Inflammatory Damage through Triggering T Cell Necroptosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJia Song,Xin Zhang,Yue Yin,Mengfan Guo,Xuyang Zhao,Likun Wang,Caixia Ren,Yuxin Yin,Xuehui Zhang,Xuliang Deng,Dan LuPubMed 36721037
- Frontiers in pharmacology 14:10824512023Exploring the molecular mechanism of Gan Shuang granules for the treatment of non-alcoholic steatohepatitis using network pharmacology, molecular docking, and experimental verification.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGuoguo Zhi,Bingjie Shao,Tianyan Zheng,Jie Mu,Jingwei Li,Yiyuan Feng,Sha Zhu,Yanni Dang,Feng Liu,Dong WangPubMed 36762105
- Frontiers in cellular and infection microbiology 12:10683242022New insights of necroptosis and immune infiltration in sepsis-induced myocardial dysfunction from bioinformatics analysis through RNA-seq in mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYan Du,Ying Zhong,Ruilin Ding,Xiaojie Wang,Fenfen Xia,Qian Zhang,Qing PengPubMed 36619743
- The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 34:211-2202022Raw Lacquer Extract from Toxicodendron vernicifluum in Combination with ONC201 Enhances the Inhibitory Effects on Colorectal Cancer Cell Activity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhezhu Jin,Yongjun JinPubMed 36511604
- Annals of translational medicine 10:4542022Long non-coding RNA MEG3 regulates the progress of osteoarthritis by regulating the miR-34a/Klotho axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGaoxin Xiong,Shuangli Wang,Zhengjun Pan,Ning Liu,Donglei Zhao,Zhengang Zha,Rende NingPubMed 35571440
- Cellular oncology (Dordrecht) 45:355-3652022Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated mA demethylation of EIF4EBP1 and MLST8 mRNA.
- Oxidative medicine and cellular longevity 2022:99556772022Exogenous Parathyroid Hormone Alleviates Intervertebral Disc Degeneration through the Sonic Hedgehog Signalling Pathway Mediated by CREB.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYou Li,Yifan Wei,He Li,Hui Che,Dengshun Miao,Cheng Ma,Yongxin RenPubMed 35265269
- Journal of translational medicine 20:1012022Promotion of microRNA-146a by histone deacetylase 4 silencing contributes to radiosensitization of esophageal carcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhonghua Lu,Yifei Yun,Yutong Zhang,Yao Ou,Meihua WangPubMed 35193602
- Chinese medical journal 135:606-6182022Paired box 5 increases the chemosensitivity of esophageal squamous cell cancer cells by promoting p53 signaling activity.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWeiwei Zhang,Wenji Yan,Niansong Qian,Quanli Han,Weitao Zhang,Guanghai DaiPubMed 35191417
- Evidence-based complementary and alternative medicine : eCAM 2022:91606162022The TCM Prescription Yi-Fei-Jie-Du-Tang Inhibit Invasive Migration and EMT of Lung Cancer Cells by Activating Autophagy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesShanshan Wang,Zaichuan Wang,Yinqiu Wu,Chao Hou,Xiaojun Dai,Qingyin Wang,Yongjian Wu,Chao Qian,Xiaochun ZhangPubMed 35132327
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA- Form
- Liquid
- Clonality
- Monoclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| WB | IHC-P | Flow Cyt | IP | |
|---|---|---|---|---|
| Human | Tested | Tested | Not recommended | Not recommended |
| Mouse | Tested | Expected | Not recommended | Not recommended |
| Rat | Tested | Expected | Not recommended | Not recommended |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1/1000 - 1/10000 | Notes - |
Species Mouse | Dilution info 1/1000 - 1/10000 | Notes - |
Species Human | Dilution info 1/1000 - 1/10000 | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100 - 1/250 | Notes Antigen retrieval is recommended. Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
Flow Cyt
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Mouse, Rat | Dilution info - | Notes - |
IP
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Mouse, Rat | Dilution info - | Notes - |
Associated Products
Select an associated product type
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Target data
Function
Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for FAS/CD95-mediated and TNFRSF1A-induced cell death (PubMed:23516580, PubMed:35338844, PubMed:35446120, PubMed:8681376, PubMed:8681377, PubMed:8962078, PubMed:9006941, PubMed:9184224). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:16916640, PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor FAS/TNFRSF6 or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-C and -D (GSDMC and GSDMD, respectively): gasdermin cleavage promotes release of the N-terminal moiety that binds to membranes and forms pores, triggering pyroptosis (PubMed:32929201, PubMed:34012073). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 and PARP2 (PubMed:8681376). Independent of its protease activity, promotes cell migration following phosphorylation at Tyr-380 (PubMed:18216014, PubMed:27109099). Isoform 5. Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. Isoform 6. Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. Isoform 7. Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). Isoform 8. Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Alternative names
MCH5, CASP8, Caspase-8, CASP-8, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, FLICE, MACH
Recommended products
Rabbit Recombinant Monoclonal Caspase-8 antibody. Suitable for WB, IHC-P and reacts with Rat, Mouse, Human samples. Cited in 34 publications.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA- Form
- Liquid
- Clonality
- Monoclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Clone number
- EPR162
- Purification technique
- Affinity purification Protein A
- Specificity
Theoretically, ab108333 should recognize p55/54, p43/41 and p18. However, in our internal tests, it only recognized pro caspase 8. We tested it side by side with ab32397. Both antibodies are KO validated, and ab32397 recognizes pro-caspase 8 and cleavage caspase 8.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Storage information
- Stable for 12 months at -20°C
Notes
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Pro Caspase-8 also known as CASP8 is an inactive precursor of caspase-8 an important enzyme in the apoptosis and necroptosis pathways. This protein has a molecular mass of approximately 55 kDa. Caspase-8 expression occurs in various tissues with higher prevalence in immune cells including T lymphocytes and natural killer cells. Researchers often use techniques like western blot for caspase 8 detection particularly when analyzing its activation state.
- Biological function summary
Pro caspase-8 plays a significant role in the regulation of apoptosis a programmed cell death process. It is initially synthesized in an inactive form and requires activation by cleavage to become functional. Pro caspase-8 integrates into the death-inducing signaling complex (DISC) following specific triggers such as Fas receptor engagement or TNF receptor activation indicating its role in response to external apoptotic signals. Its activation marks the initiation of a cascade that results in apoptosis ensuring controlled cell removal in multicellular organisms.
- Pathways
Pro caspase-8 functions within the extrinsic apoptosis pathway where it serves as an initiator caspase. Alongside other proteins like Fas-associated protein with death domain (FADD) caspase-8 forms a critical part of the apoptotic signaling network. Another important pathway involving pro caspase-8 is necroptosis an alternative form of programmed cell death where it can inhibit the function of receptor-interacting protein kinase 1 (RIPK1) and RIPK3 under certain conditions. The regulation of these pathways highlights pro caspase-8's central role in determining cell fate under stress or damage.
- Associated diseases and disorders
Aberrations in pro caspase-8 activity link to various conditions such as cancer and autoimmune diseases. In cancers insufficient caspase-8 activation results in the evasion of apoptosis allowing uncontrolled cell proliferation. Meanwhile excessive or improper activation associates with autoimmune disorders where unregulated apoptosis leads to immune system imbalance. Pro caspase-8 connects with proteins like FLICE-like inhibitory protein (c-FLIP) in cancer where it influences the apoptotic threshold and contributes to the pathology.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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8 product images
![Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--western-blot-img155016.jpg "Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)")
Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)
Lane 1: Wild-type HAP1 cell lysate (20 μg)
Lane 2: Pro Caspase-8 knockout HAP1 cell lysate (20 μg)
Lanes 1 and 2: Merged signal (red and green). Green - ab108333 observed at 55 kDa. Red - loading control, Anti-GAPDH antibody [6C5] - Loading Control ab8245, observed at 37 kDa.ab108333 was shown to specifically react with Caspase-8 when Caspase-8 knockout samples were used. Wild-type and Pro Caspase-8 knockout samples were subjected to SDS-PAGE. ab108333 and Anti-GAPDH antibody [6C5] - Loading Control ab8245 (loading control to GAPDH) were both diluted 1/1000 and incubated overnight at 4°C. Blots were developed with Goat anti-Rabbit IgG H&L (IRDye® 800CW) preadsorbed (Goat anti-Rabbit IgG H&L (IRDye® 800CW) preadsorbed ab216773) and Goat anti-Mouse IgG H&L (IRDye® 680RD) preadsorbed (Goat anti-Mouse IgG H&L (IRDye® 680RD) preadsorbed ab216776) secondary antibodies at 1/10 000 dilution for 1 h at room temperature before imaging.
All lanes: Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)
Predicted band size: 55 kDa
![Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--western-blot-img4838.jpg "Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)")
Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)
Lanes 1 - 3: Merged signal (red and green). Green - ab108333 observed at 55 kDa. Red - loading control, Anti-GAPDH antibody [6C5] - Loading Control ab8245, observed at 37 kDa.
This blot was produced using a 4-12% Bis-tris gel under the MOPS buffer system. The gel was run at 200V for 50 minutes before being transferred onto a Nitrocellulose membrane at 30V for 70 minutes. The membrane was then blocked for an hour using Licor blocking buffer before being incubated with ab108333 and Anti-GAPDH antibody [6C5] - Loading Control ab8245 (loading control) overnight at 4°C. Antibody binding was detected using Goat anti-Rabbit IgG H&L (IRDye® 800CW) preabsorbed (Goat anti-Rabbit IgG H&L (IRDye® 800CW) preadsorbed ab216773) and Goat anti-Mouse IgG H&L (IRDye® 680RD) preabsorbed (Goat anti-Mouse IgG H&L (IRDye® 680RD) preadsorbed ab216776) at a 1:10000 dilution for 1hr at room temperature and then imaged.
All lanes: Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333) at 1/1000 dilution
Lane 1: HepG2 whole cell lysate at 20 µg
Lane 2: Rat liver tissue lysate at 20 µg
Lane 3: Mouse liver tissue lysate at 20 µg
SecondaryAll lanes: Western blot - Goat anti-Rabbit IgG H&L (IRDye® 800CW) preadsorbed (Goat anti-Rabbit IgG H&L (IRDye® 800CW) preadsorbed ab216773) at 1/10000 dilution
Performed under reducing conditions.
Predicted band size: 55 kDa
Observed band size: 55 kDa
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pro Caspase-8 antibody [EPR162] (ab108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img137554.gif "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)
ab108333, at 1/100 dilution, staining Pro Caspase-8 in paraffin-embedded human tonsil tissue by Immunohistochemistry.
Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
![Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--western-blot-img163887.jpg "Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)")
Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)
Lane 1: Wild-type HAP1 cell lysate (20 μg)
Lane 2: Pro Caspase-8 knockout HAP1 cell lysate (20 μg)
Lanes 1 and 2: Merged signal (red and green).Green - target observed at 55 kDa. Red - loading control, Anti-GAPDH antibody [6C5] - Loading Control ab8245, observed at 37 kDa.
This western blot image is a comparison between ab108333 and a competitor's top cited mouse monoclonal antibody.
All lanes: Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)
Predicted band size: 55 kDa
![Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--western-blot-img115772.jpg "Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)")
Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)
All lanes: Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333) at 1/1000 dilution
Lane 1: Jurkat cell lysate at 10 µg
Lane 2: IM9 cell lysate at 10 µg
Lane 3: HepG2 cell lysate at 10 µg
Lane 4: HL60 cell lysate at 10 µg
Predicted band size: 55 kDa
![Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--western-blot-img116272.jpg "Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)")
Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)
All lanes: Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333) at 1/1000 dilution
Lane 1: Jurkat cell lysate, treated with etoposide at 10 µg
Lane 2: Jurkat cell lysate at 10 µg
Lane 3: HeLa cell lysate, treated staurosporine at 10 µg
Lane 4: HeLa cell lysate at 10 µg
Predicted band size: 55 kDa
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pro Caspase-8 antibody [EPR162] (ab108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--immunohistochemistry-formalin-pfa-fixed-paraffin-embedded-sections-img138835.gif "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)")
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)
ab108333, at 1/100 dilution, staining Pro Caspase-8 in paraffin-embedded human hepatocellular carcinoma by Immunohistochemistry.
Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
![Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--western-blot-img438509.jpg "Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)")
Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)
Blocking and diluting buffer: 5% NFDM /TBST.
Exposure time:
Lane 1 & 2: 7 seconds
Lane 3 & 4: 3 seconds
Lanes 1 - 2: Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333) at 1/1000 dilution
Lanes 3 - 4: Western blot - Anti-Caspase-10/CASP-10 antibody [EPR10890] (Anti-Caspase-10/CASP-10 antibody [EPR10890] ab177475) at 1/1000 dilution
Lanes 1 - 2: His-tagged Human full-length Caspase 8 recombinant protein at 10 ng
Lanes 3 - 4: His-tagged Human full-length Caspase 10 recombinant protein at 10 ng
SecondaryAll lanes: Western blot - Goat Anti-Rabbit IgG H&L (HRP) (Goat Anti-Rabbit IgG H&L (HRP) ab97051) at 1/20000 dilution
Observed band size: 60-70 kDa
![Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--western-blot-img116272.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)")
![Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333), expandable thumbnail](https://content.abcam.com/products/images/pro-caspase-8-antibody-epr162-ab108333--western-blot-img438509.jpg/_jcr_content/renditions/webp-475.webp "Western blot - Anti-Pro Caspase-8 antibody [EPR162] (ab108333)")
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