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AB202139

Anti-proCNP antibody - C-terminal

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(2 Publications)

Rabbit Polyclonal proCNP antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NPPC.

View Alternative Names

CNP2, NPPC, C-type natriuretic peptide

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-proCNP antibody - C-terminal (AB202139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-proCNP antibody - C-terminal (AB202139)

Immunohistochemical analysis of paraffin-embedded human gastric cancer tissue labeling proCNP with ab202139 at 1/70.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human NPPC. The exact immunogen used to generate this antibody is proprietary information.

P23582

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ProCNP also known as pro-C-type natriuretic peptide is an inactive precursor to C-type natriuretic peptide (CNP) a member of the natriuretic peptide family. ProCNP has a molecular mass of approximately 12 kDa. This peptide is particularly expressed in the central nervous system bones and blood vessels. CNP is widely distributed in brain tissues and offers significant biological effects in these areas which are contrasted to the limited distribution and distinct functions of the other natriuretic peptides.
Biological function summary

Pro-C-type natriuretic peptide plays an important role in the regulation of vascular tone and bone growth. It does not act on its own but must be processed into active CNP to exert its functions. CNP does not work as part of a complex but directly interacts with particulate guanylyl cyclase membrane receptor-B (NPR-B) which mediates its effects on target tissues by increasing cyclic guanosine monophosphate (cGMP) levels.

Pathways

ProCNP influences two main pathways: the natriuretic peptide signaling pathway and bone development pathways. In particular CNP derived from proCNP regulates endochondral ossification and promotes chondrocyte differentiation. This regulation is essential in growth plate development and bone lengthening. CNP associated with natriuretic peptide receptor B contrasts with atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) which more intensely modulate cardiovascular functions.

ProCNP when processed to CNP demonstrates a link to achondroplasia a genetic disorder of bone growth leading to dwarfism. Alterations in the CNP-NPR-B pathway due to genetic mutations can impair normal bone development. Moreover it has an association with cardiovascular conditions where abnormal levels affect vascular homeostasis. These effects relate to the interaction with other natriuretic peptides like BNP as studies frequently measure proCNP levels alongside BNP in heart-related assessments.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

CNP-22. Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic (PubMed : 1672777). Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed : 1672777, PubMed : 21098034). Binds the clearance receptor NPR3 (PubMed : 11533490).
See full target information NPPC
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Investigative ophthalmology & visual science 64:5 PubMed37792336

2023

Single-Cell Transcriptomics Reveals Cellular Heterogeneity and Complex Cell-Cell Communication Networks in the Mouse Cornea.

Applications

Unspecified application

Species

Unspecified reactive species

Yueh-Feng Wu,Nai-Wen Chang,Li-An Chu,Hsin-Yu Liu,Yu-Xian Zhou,Yun-Lin Pai,Yu-Sheng Yu,Chen-Hsiang Kuan,Yu-Ching Wu,Sung-Jan Lin,Hsin-Yuan Tan

Journal of molecular histology 51:3-13 PubMed31722080

2019

Natriuretic peptide system expression in murine and human submandibular salivary glands: a study of the spatial localisation of ANB, BNP, CNP and their receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Araz Ahmed,Alessandro Gulino,Simita Amayo,Walter Arancio,Ada Maria Florena,Beatrice Belmonte,Abdo Jurjus,Angelo Leone,Isabelle Miletich
View all publications
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