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AB48001

Anti-PRODH antibody

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(1 Publication)

Goat Polyclonal PRODH antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PRODH aa 50-100.

View Alternative Names

PIG6, POX2, PRODH2, PRODH, Proline oxidase, Proline oxidase 2, p53-induced gene 6 protein

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PRODH aa 50-100. The exact immunogen used to generate this antibody is proprietary information.

O43272

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PRODH also known as proline dehydrogenase or proline oxidase is an enzyme that plays an important mechanical role in proline metabolism. This mitochondrial protein with a mass of approximately 64 kDa catalyzes the conversion of proline to pyrroline-5-carboxylate a step important in proline degradation. PRODH is mainly expressed in several tissues including the brain heart and kidney which suggests its importance in various physiological processes.
Biological function summary

PRODH contributes to cellular energy production and redox balance by participating in proline catabolism. It operates as part of the proline utilization pathway carrying out key reactions necessary for maintaining amino acid balance and energy homeostasis. Although PRODH functions independently it collaborates with other enzymes in the mitochondrial matrix to facilitate efficient energy production and metabolic regulation.

Pathways

PRODH is involved in proline and arginine metabolism which intersects with the urea cycle and glutamate metabolism. Its activity impinges on the regulation of key pathways like the Krebs cycle through its product pyrroline-5-carboxylate which further converts to glutamate. In this context PRODH is functionally related to other enzymes such as pyrroline-5-carboxylate reductase which modulates the flow and conversion of metabolites within these pathways.

Researchers have linked PRODH to disorders like schizophrenia and cancer. Altered expression or mutations in the PRODH gene can impact metabolic flux in the brain contributing to neuropsychiatric conditions such as schizophrenia. Also the enzyme's role in proline metabolism connects it to tumorogenesis where shifts in metabolic pathways support cancer cell growth. PRODH's interactions with proteins like p53 suggest a potential mechanism for its involvement in oncogenic processes highlighting its significance in disease progression and therapeutic target potential.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Converts proline to delta-1-pyrroline-5-carboxylate.
See full target information PRODH
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular cancer therapeutics 9:1158-68 PubMed20406950

2010

1,25-dihydroxyvitamin D3 enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53.

Applications

WB

Species

Human

Thelma Thompson,Michael Andreeff,George P Studzinski,Lyubomir T Vassilev
View all publications
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Product promise

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