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AB11137

Anti-ProDynorphin antibody

4

(3 Reviews)

|

(7 Publications)

Rabbit Polyclonal ProDynorphin antibody. Suitable for IHC-Fr and reacts with Mouse, Rat samples. Cited in 7 publications. Immunogen corresponding to Synthetic Peptide within Rat Pdyn.

View Alternative Names

Proenkephalin-B, Beta-neoendorphin-dynorphin, Preprodynorphin, PDYN

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat

Applications

IHC-Fr

applications

Immunogen

Synthetic Peptide within Rat Pdyn. The exact immunogen used to generate this antibody is proprietary information.

P06300

Specificity

This antibody blocks specifically with leumorphin (rat only). Cells are found in the paraventricular and supraoptic nucleus and fibres in the lateral hypothalamus in rat brain of colchicine treated 4% FA perfused tissue.

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Alternative Products

Primary Antibodies

AB217160

Anti-ProDynorphin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ProDynorphin antibody (AB217160)

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Complementary Products

Assay Kits

AB309116

Rat ProDynorphin ELISA Kit

SimpleStep

Sandwich ELISA - Rat ProDynorphin ELISA Kit (AB309116)

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Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

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Primary Antibodies

AB302667

Anti-c-Fos antibody [N486/32]

BOND RX™ Validated|Recombinant|Lab Essentials|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Fos antibody [N486/32] (AB302667)

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Primary Antibodies

AB16046

Anti-FOXP2 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FOXP2 antibody (AB16046)

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Primary Antibodies

AB150346

Anti-Leu Enkephalin antibody [NOC1]

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "1/100 - 1/2000", "IHCFr-species-notes": "<p></p>" }, "Rat": { "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "1/100 - 1/2000", "IHCFr-species-notes": "<p></p>" } } }
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Product details

This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Preservative: 0.09% Sodium azide Constituents: PBS, 5% Sucrose, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Dynorphin B often referred to as Big Dynorphin is an opioid peptide that belongs to the endorphin family. This peptide is derived from the precursor protein prodynorphin also known by the gene symbol PDYN. Dynorphin B typically has a mass of around 3.4 kDa. It expresses mainly in the central nervous system particularly within the hypothalamus hippocampus and spinal cord. These locations correspond to its function as a modulator of neural activity often influencing pain perception and stress response.
Biological function summary

Dynorphin B acts as a neurotransmitter and neuromodulator. It binds to the kappa-opioid receptor forming a complex that modulates synaptic transmission. Dynorphin B influences several neurological processes including the regulation of dopamine levels and the modulation of pain pathways. Given its role in neural signaling dynorphin B is involved in regulating the body's response to stress and addiction mechanisms.

Pathways

The activity of dynorphin B integrates primarily within the nociceptive pathway and stress-related pathways. The peptide's interaction with the kappa-opioid receptor significantly influences these pathways. It's related to other opioid peptides such as beta-endorphin and enkephalins. These interactions affect the release of neurotransmitters and consequent biological responses which are important in the body's adaptation to stress and perception of pain.

Dynorphin B has significant connections to conditions like addiction and depression. In addiction altered levels and signaling of dynorphin B contribute to the reinforcing properties of addictive substances by impacting dopamine transmission. In depression the dysregulation of dynorphin B and its receptor interactions play roles in mood disturbances and stress response. These conditions also relate to the complex interplay with beta-endorphin which suggests overlapping pathways and physiological effects amongst these opioid peptides.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).. Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin (By similarity).. Leumorphin has a typical opioid activity and may have anti-apoptotic effect.
See full target information PDYN
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Publications (7)

Recent publications for all applications. Explore the full list and refine your search

eNeuro 11: PubMed39592219

2024

The External Globus Pallidus as the Hub of the Auditory Cortico-Basal Ganglia Loop.

Applications

Unspecified application

Species

Unspecified reactive species

Ryohei Tomioka,Naoki Shigematsu,Toshio Miyashita,Yukie Takahashi,Mariko Yamamoto,Yumiko Yoshimura,Kenta Kobayashi,Yuchio Yanagawa,Nobuaki Tamamaki,Takaichi Fukuda,Wen-Jie Song

Cell biology international 46:1814-1824 PubMed35989483

2022

Dynorphin/KOR inhibits neuronal autophagy by activating mTOR signaling pathway to prevent acute seizure epilepsy.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Liu,Zuoliang Liu,Chunyun Zeng,Yingtong Xu,Li He,Qing Fang,Zhiheng Chen

Neuroscience 495:58-73 PubMed35643248

2022

Anterior Insular-nucleus Accumbens Pathway Controls Refeeding-induced Analgesia under Chronic Inflammatory Pain Condition.

Applications

Unspecified application

Species

Unspecified reactive species

Grace J Lee,Yea Jin Kim,Sang Wook Shim,Kihwan Lee,Seog Bae Oh

Nature communications 11:1729 PubMed32265438

2020

TrkB-expressing paraventricular hypothalamic neurons suppress appetite through multiple neurocircuits.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Ji An,Clint E Kinney,Ji-Wei Tan,Guey-Ying Liao,Eric J Kremer,Baoji Xu

The Journal of neuroscience : the official journal of the Society for Neuroscience 35:4296-305 PubMed25762676

2015

κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake.

Applications

Unspecified application

Species

Unspecified reactive species

Timothy W Whitfield,Joel E Schlosburg,Sunmee Wee,Adam Gould,Olivier George,Yanabel Grant,Eva R Zamora-Martinez,Scott Edwards,Elena Crawford,Leandro F Vendruscolo,George F Koob

The Journal of neuroscience : the official journal of the Society for Neuroscience 33:19384-92 PubMed24305833

2013

Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake.

Applications

Unspecified application

Species

Rat

Joel E Schlosburg,Timothy W Whitfield,Paula E Park,Elena F Crawford,Olivier George,Leandro F Vendruscolo,George F Koob

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 38:1296-307 PubMed23348063

2013

Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.

Applications

Unspecified application

Species

Unspecified reactive species

Amparo Romero-Picó,Maria J Vázquez,David González-Touceda,Cintia Folgueira,Karolina P Skibicka,Mayte Alvarez-Crespo,Margriet A Van Gestel,Douglas A Velásquez,Christoph Schwarzer,Herbert Herzog,Miguel López,Roger A Adan,Suzanne L Dickson,Carlos Diéguez,Rubén Nogueiras
View all publications
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Product promise

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