Anti-Progesterone Receptor antibody
4
(5 Reviews)
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(20 Publications )
- IHC-P
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody (AB63605)
Paraffin-embedded human liver carcinoma tissue stained for Progesterone Receptor with ab63605 at 1/50 dilution in immunohistochemical analysis.
In the right-hand panel the sample is incubated with the immunizing peptide.
- ICC/IF
Unknown
Immunocytochemistry/ Immunofluorescence - Anti-Progesterone Receptor antibody (AB63605)
ab63605, at a 1/500 dilution, staining Human Progesterone Receptor in A549 cells, with (+) or without (-) immunising peptide, by Immunofluorescence.
- IHC-P
AbReview77636****
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody (AB63605)
Immunohistochemistry analysis (Formalin/PFA-fixed paraffin-embedded sections) of paraformaldehyde fixed human placenta tissue. Stained with ab63605 at 1/2000 dilution. Secondary antibody used was EnVision+ System- HRP Labelled Polymer anti rabbit. Blocking was done with 5% serum for 1 hour at 21°C. The sample was incubated with the primary antibody and 5% normal goat serum for 19 hours at 4°C. Antigen retrieval method was heat mediated Tris/EDTA pH 9.0
This image is courtesy of an anonymous Abreview
- IHC-P
AbReview44871****
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody (AB63605)
ab63605 staining Progesterone Receptor in Mouse uterus tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde, permeabilized with 0.3% Triton X-100 and blocked with 2% BSA for 1 hour at room temperature; antigen retrieval was by heat mediation in Tris_EDTA. Samples were incubated with primary antibody (1/100) for 10 hours at 4°C. A HRP-conjugated goat anti-rabbit IgG polyclonal (1/100) was used as the secondary antibody.
This image is courtesy of an Abreview submitted by Daniel Murta
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Biological function summary
The progesterone receptor plays a significant role in regulating gene expression related to reproductive processes. PR is not part of a larger complex by itself but interacts with various coactivators and corepressors to modulate transcription. In the uterus and mammary glands PR mediates the effects of progesterone by promoting cell proliferation and preparing tissues for pregnancy. In other systems PR also links to various metabolic and immunological pathways influencing cell cycle progression and immune response.
Pathways
Progesterone receptor activity is integrated within the reproductive hormone signaling pathways and the Wnt signaling pathway. The receptor interacts directly with key proteins such as estrogen receptor (ER) and steroid receptor coactivator (SRC) complexes which are pivotal in modulating response to hormonal signals. These interactions underline the essential role of PR in maintaining hormonal balance and regulating reproductive functions.
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Publications (20)
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JCI insight 10: PubMed40504614
2025
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Discover oncology 16:814 PubMed40388071
2025
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Cancer cell international 24:433 PubMed39731167
2024
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Biology 13: PubMed38534461
2024
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British journal of cancer 130:1109-1118 PubMed38341511
2024
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Cancer gene therapy 30:1114-1123 PubMed37188724
2023
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iScience 26:106523 PubMed37123232
2023
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Theranostics 12:6527-6547 PubMed36185612
2022
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Frontiers in cell and developmental biology 9:723978 PubMed34957089
2021
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Nature communications 12:5389 PubMed34508101
2021
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