JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB63605

Anti-Progesterone Receptor antibody

4

(5 Reviews)

|

(20 Publications )

Rabbit Polyclonal Progesterone Receptor antibody. Suitable for ICC, ELISA, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 20 publications. Immunogen corresponding to Synthetic Peptide within Human PGR.
4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody (AB63605)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody (AB63605)

Paraffin-embedded human liver carcinoma tissue stained for Progesterone Receptor with ab63605 at 1/50 dilution in immunohistochemical analysis.

In the right-hand panel the sample is incubated with the immunizing peptide.

Immunocytochemistry/ Immunofluorescence - Anti-Progesterone Receptor antibody (AB63605)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Progesterone Receptor antibody (AB63605)

ab63605, at a 1/500 dilution, staining Human Progesterone Receptor in A549 cells, with (+) or without (-) immunising peptide, by Immunofluorescence.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody (AB63605)
  • IHC-P

AbReview77636****

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody (AB63605)

Immunohistochemistry analysis (Formalin/PFA-fixed paraffin-embedded sections) of paraformaldehyde fixed human placenta tissue. Stained with ab63605 at 1/2000 dilution. Secondary antibody used was EnVision+ System- HRP Labelled Polymer anti rabbit. Blocking was done with 5% serum for 1 hour at 21°C. The sample was incubated with the primary antibody and 5% normal goat serum for 19 hours at 4°C. Antigen retrieval method was heat mediated Tris/EDTA pH 9.0

This image is courtesy of an anonymous Abreview

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody (AB63605)
  • IHC-P

AbReview44871****

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody (AB63605)

ab63605 staining Progesterone Receptor in Mouse uterus tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde, permeabilized with 0.3% Triton X-100 and blocked with 2% BSA for 1 hour at room temperature; antigen retrieval was by heat mediation in Tris_EDTA. Samples were incubated with primary antibody (1/100) for 10 hours at 4°C. A HRP-conjugated goat anti-rabbit IgG polyclonal (1/100) was used as the secondary antibody.

This image is courtesy of an Abreview submitted by Daniel Murta

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse

Applications

IHC-P, ICC, ICC/IF, ELISA

applications

Immunogen

Synthetic Peptide within Human PGR. The exact immunogen used to generate this antibody is proprietary information.

P06401

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab63605 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Stable for 12 months at -20°C

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The progesterone receptor (PR) also known as NR3C3 is a nuclear receptor that functions as a transcription factor in response to the hormone progesterone. This receptor has a mass of approximately 99 kDa and is expressed in tissues such as the reproductive organs including the uterus ovaries and mammary glands. It is also found in non-reproductive tissues like the brain and bone. The receptor has two main isoforms PR-A and PR-B which differ slightly in structure but have unique biological roles.
Biological function summary

The progesterone receptor plays a significant role in regulating gene expression related to reproductive processes. PR is not part of a larger complex by itself but interacts with various coactivators and corepressors to modulate transcription. In the uterus and mammary glands PR mediates the effects of progesterone by promoting cell proliferation and preparing tissues for pregnancy. In other systems PR also links to various metabolic and immunological pathways influencing cell cycle progression and immune response.

Pathways

Progesterone receptor activity is integrated within the reproductive hormone signaling pathways and the Wnt signaling pathway. The receptor interacts directly with key proteins such as estrogen receptor (ER) and steroid receptor coactivator (SRC) complexes which are pivotal in modulating response to hormonal signals. These interactions underline the essential role of PR in maintaining hormonal balance and regulating reproductive functions.

The progesterone receptor associates with breast cancer and endometriosis. Aberrant expression or mutations in PR can contribute to the development and progression of breast cancer often linked with the estrogen receptor's influence. In endometriosis PR's altered functionality affects cellular response to progesterone contributing to tissue growth outside the uterus. These conditions also involve interactions with proteins like BRCA1 in breast cancer highlighting how PR connects to broader cellular and pathological networks.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Target data

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor.. Isoform A. Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.. Isoform B. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.. Isoform 4. Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
See full target information PGR

Alternative Names

NR3C3, PGR, Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3

Publications (20)

Recent publications for all applications. Explore the full list and refine your search

JCI insight 10: PubMed40504614

2025

Role of progesterone action in inguinal hernia formation via skeletal muscle fibrosis and atrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Tianming You,Mehrdad Zandigohar,Tanvi Potluri,Natalie Piehl,John S Coon V,Elizabeth Baker,Maya Kafali,Yang Dai,Jonah J Stulberg,David J Escobar,Richard L Lieber,Hong Zhao,Serdar E Bulun

Discover oncology 16:814 PubMed40388071

2025

Mucinous breast cancer organoids: an in vitro research model.

Applications

Unspecified application

Species

Unspecified reactive species

Dongyi Zhao,Shida Zhu,Xue Bai,Xuelu Li,Zuowei Zhao

Cancer cell international 24:433 PubMed39731167

2024

Organoids as a model system for researching human neuroendocrine tumor of the breast.

Applications

Unspecified application

Species

Unspecified reactive species

Dongyi Zhao,Xue Bai,Shida Zhu,Zuowei Zhao,Xuelu Li

Biology 13: PubMed38534461

2024

Estrogen and Progesterone Receptors Are Dysregulated at the BPH/5 Mouse Preeclamptic-Like Maternal-Fetal Interface.

Applications

Unspecified application

Species

Unspecified reactive species

Viviane C L Gomes,Bryce M Gilbert,Carolina Bernal,Kassandra R Crissman,Jenny L Sones

British journal of cancer 130:1109-1118 PubMed38341511

2024

Organoid forming potential as complementary parameter for accurate evaluation of breast cancer neoadjuvant therapeutic efficacy.

Applications

Unspecified application

Species

Unspecified reactive species

Hai-Shan Ye,Dan Zhou,Hong Li,Jin Lv,Hui-Qi Huang,Jia-Jun She,Jun-Hua Nie,Ting-Ting Li,Meng-Di Lu,Bo-Le Du,Shu-Qing Yang,Pei-Xian Chen,Sheng Li,Guo-Lin Ye,Wei Luo,Jia Liu

Cancer gene therapy 30:1114-1123 PubMed37188724

2023

Respective roles of Pik3ca mutations and cyproterone acetate impregnation in mouse meningioma tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Pierre-Cyril Cômes,Tuan Le Van,Suzanne Tran,Solène Huard,Samiya Abi-Jaoude,Quitterie Venot,Pauline Marijon,Julien Boetto,Antoine Blouin,Franck Bielle,Yohan Ducos,Yu Teranishi,Michel Kalamarides,Matthieu Peyre

iScience 26:106523 PubMed37123232

2023

Progesterone prevents HGSOC by promoting precancerous cell pyroptosis via inducing fibroblast paracrine.

Applications

Unspecified application

Species

Unspecified reactive species

Nayiyuan Wu,Xiaoye Zhang,Zhibin Wang,Xiu Zhang,Chao Fang,He Li,Miaochen Zhu,Ying Wang,Qianjin Liao,Tang-Yuan Chu,Jing Wang

Theranostics 12:6527-6547 PubMed36185612

2022

Single-cell transcriptome profiling of the human endometrium of patients with recurrent implantation failure.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen-Zhen Lai,Yun Wang,Wen-Jie Zhou,Zhou Liang,Jia-Wei Shi,Hui-Li Yang,Feng Xie,Wei-Dong Chen,Rui Zhu,Ce Zhang,Jie Mei,Jian-Yuan Zhao,Jiang-Feng Ye,Tao Zhang,Ming-Qing Li

Frontiers in cell and developmental biology 9:723978 PubMed34957089

2021

Disruption of Folate Metabolism Causes Poor Alignment and Spacing of Mouse Conceptuses for Multiple Generations.

Applications

Unspecified application

Species

Unspecified reactive species

Amy L Wilkinson,Katerina Menelaou,Joanna Rakoczy,Xiu S Tan,Erica D Watson

Nature communications 12:5389 PubMed34508101

2021

Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Vrutant V Shah,Aundrietta D Duncan,Shiming Jiang,Sabrina A Stratton,Kendra L Allton,Clinton Yam,Abhinav Jain,Patrick M Krause,Yue Lu,Shirong Cai,Yizheng Tu,Xinhui Zhou,Xiaomei Zhang,Yan Jiang,Christopher L Carroll,Zhijun Kang,Bin Liu,Jianjun Shen,Mihai Gagea,Sebastian M Manu,Lei Huo,Michael Gilcrease,Reid T Powell,Lei Guo,Clifford Stephan,Peter J Davies,Jan Parker-Thornburg,Guillermina Lozano,Richard R Behringer,Helen Piwnica-Worms,Jeffrey T Chang,Stacy L Moulder,Michelle Craig Barton
View all publications

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com