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AB191138

Anti-Progesterone Receptor antibody - C-terminal

4

(7 Reviews)

|

(11 Publications)

Rabbit Polyclonal Progesterone Receptor antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PGR aa 550 to C-terminus.

View Alternative Names

NR3C3, PGR, Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody - C-terminal (AB191138)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody - C-terminal (AB191138)

Immunohistochemical analysis of paraffin-embedded Human Mammary Cancer Tissue labeling Progesterone Receptor with ab191138 at 1 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody - C-terminal (AB191138)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody - C-terminal (AB191138)

Immunohistochemical analysis of paraffin-embedded Human Lung Cancer Tissue labeling Progesterone Receptor with ab191138 at 1 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody - C-terminal (AB191138)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody - C-terminal (AB191138)

Immunohistochemical analysis of paraffin-embedded Human Intestinal Cancer Tissue labeling Progesterone Receptor with ab191138 at 1 μg/ml.

Western blot - Anti-Progesterone Receptor antibody - C-terminal (AB191138)
  • WB

Supplier Data

Western blot - Anti-Progesterone Receptor antibody - C-terminal (AB191138)

Blocking buffer : 5% non-fat milk/ TBS for 1.5 hours at room temperature.

All lanes:

Western blot - Anti-Progesterone Receptor antibody - C-terminal (ab191138) at 0.1 µg/mL

All lanes:

Human T-47D whole cell lysates. at 50 µg

Secondary

All lanes:

Goat anti-Rabbit IgG-HRP for 1.5 hours at room temperature at 1/10000 dilution

Predicted band size: 98 kDa

Observed band size: 90 kDa,99 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PGR aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P06401

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.025% Sodium azide Constituents: 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The progesterone receptor (PR) also known as NR3C3 is a nuclear receptor that functions as a transcription factor in response to the hormone progesterone. This receptor has a mass of approximately 99 kDa and is expressed in tissues such as the reproductive organs including the uterus ovaries and mammary glands. It is also found in non-reproductive tissues like the brain and bone. The receptor has two main isoforms PR-A and PR-B which differ slightly in structure but have unique biological roles.
Biological function summary

The progesterone receptor plays a significant role in regulating gene expression related to reproductive processes. PR is not part of a larger complex by itself but interacts with various coactivators and corepressors to modulate transcription. In the uterus and mammary glands PR mediates the effects of progesterone by promoting cell proliferation and preparing tissues for pregnancy. In other systems PR also links to various metabolic and immunological pathways influencing cell cycle progression and immune response.

Pathways

Progesterone receptor activity is integrated within the reproductive hormone signaling pathways and the Wnt signaling pathway. The receptor interacts directly with key proteins such as estrogen receptor (ER) and steroid receptor coactivator (SRC) complexes which are pivotal in modulating response to hormonal signals. These interactions underline the essential role of PR in maintaining hormonal balance and regulating reproductive functions.

The progesterone receptor associates with breast cancer and endometriosis. Aberrant expression or mutations in PR can contribute to the development and progression of breast cancer often linked with the estrogen receptor's influence. In endometriosis PR's altered functionality affects cellular response to progesterone contributing to tissue growth outside the uterus. These conditions also involve interactions with proteins like BRCA1 in breast cancer highlighting how PR connects to broader cellular and pathological networks.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as a transcriptional activator or repressor.. Isoform A. Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.. Isoform B. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.. Isoform 4. Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
See full target information PGR
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Publications (11)

Recent publications for all applications. Explore the full list and refine your search

PloS one 20:e0331209 PubMed40911583

2025

Expression of hormonal receptors and Toll-like receptors in cultured canine uterine explants with pseudoplacentational endometrial hyperplasia and bacterial-elicited endometrial inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Clarissa Helena Santana,Monique Ferreira Silva Souza,Laice Silva,Lucas Dos Reis Souza,Ayisa Rodrigues Oliveira,Álan Maia Borges,Tatiane Paixão,Renato Lima Santos

Veterinary world 18:1725-1740 PubMed40689167

2025

Establishment and molecular characterization of novel luminal A and luminal B canine mammary cancer cell lines for comparative oncology.

Applications

Unspecified application

Species

Unspecified reactive species

Juthathip Jurutha,Yanika Piyasanti,Kornkanok Sritabtim,Suparat Chaipipat,Kannika Siripattarapravat,Sukumal Prukudom,Usuma Jermnak,Rungthiwa Sinsiri,Kakanang Wongsuppabut,Charuwan Wongsali,Nutawan Niyatiwatchanchai,Wijit Sutthiprapa,Napachanok Swainson,Wachiraphan Supsavhad

Pharmaceuticals (Basel, Switzerland) 17: PubMed39770574

2025

The Role of Curcumin in Preventing Naturally Occurring Leiomyoma in the Galline Model.

Applications

Unspecified application

Species

Unspecified reactive species

Kazim Sahin,Cemal Orhan,Mehmet Tuzcu,Nurhan Sahin,Ibrahim H Ozercan,Nashwa Kabil,Omer Kucuk,Bulent Ozpolat

Journal of translational medicine 22:352 PubMed38622667

2024

Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic.

Applications

Unspecified application

Species

Unspecified reactive species

Qiao Jin,Chiyuan Zhang,Ran Chen,Luping Jiang,Hongli Li,Pengcui Wu,Liang Li

International journal of molecular sciences 24: PubMed37686439

2023

Novel Correlation between TGF-β1/-β3 and Hormone Receptors in the Human Corneal Stroma.

Applications

Unspecified application

Species

Unspecified reactive species

Alexander J Choi,Brenna S Hefley,Sarah E Nicholas,Rebecca L Cunningham,Dimitrios Karamichos

The American journal of pathology 193:1762-1775 PubMed36822267

2023

Selective Modulation of the Keratoconic Stromal Microenvironment by FSH and LH.

Applications

Unspecified application

Species

Unspecified reactive species

Paulina Escandon,Sarah E Nicholas,Brenda Vasini,Rebecca L Cunningham,David A Murphy,Kamran M Riaz,Dimitrios Karamichos

International journal of molecular sciences 23: PubMed35055103

2022

The Role of Estriol and Estrone in Keratoconic Stromal Sex Hormone Receptors.

Applications

Unspecified application

Species

Unspecified reactive species

Paulina Escandon,Sarah E Nicholas,Rebecca L Cunningham,David A Murphy,Kamran M Riaz,Dimitrios Karamichos

Frontiers in oncology 11:744256 PubMed34671560

2021

Patient-Derived Xenografts Are a Reliable Preclinical Model for the Personalized Treatment of Epithelial Ovarian Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jiayu Chen,Ying Jin,Siyi Li,Cui Qiao,Xinxin Peng,Yan Li,Yu Gu,Wei Wang,Yan You,Jie Yin,Ying Shan,Yong-Xue Wang,Meng Qin,Hongyue Li,Yan Cai,Yu Dong,Siying Peng,Lingya Pan

Journal of morphology 282:720-732 PubMed33638264

2021

Prenatal development in Lagostomus maximus (Rodentia, Chinchillidae): A unique case among eutherian mammals of physiological embryonic death.

Applications

Unspecified application

Species

Unspecified reactive species

Francisco Acuña,Claudio G Barbeito,Enrique L Portiansky,María A Miglino,Mirta A Flamini

Archives of oral biology 122:105026 PubMed33348207

2020

Donor variation and sex hormone receptors in periodontal ligament cells.

Applications

Unspecified application

Species

Unspecified reactive species

Anja Quast,Viktor Martian,Annegret Bohnsack,Sarah Batschkus,Philipp Meyer-Marcotty,Nicolai Miosge
View all publications
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