Rabbit Polyclonal Progesterone Receptor antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PGR aa 550 to C-terminus.
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Publications
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- International journal of molecular sciences 23:2022The Role of Estriol and Estrone in Keratoconic Stromal Sex Hormone Receptors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPaulina Escandon,Sarah E Nicholas,Rebecca L Cunningham,David A Murphy,Kamran M Riaz,Dimitrios KaramichosPubMed 35055103
- Frontiers in oncology 11:7442562021Patient-Derived Xenografts Are a Reliable Preclinical Model for the Personalized Treatment of Epithelial Ovarian Cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiayu Chen,Ying Jin,Siyi Li,Cui Qiao,Xinxin Peng,Yan Li,Yu Gu,Wei Wang,Yan You,Jie Yin,Ying Shan,Yong-Xue Wang,Meng Qin,Hongyue Li,Yan Cai,Yu Dong,Siying Peng,Lingya PanPubMed 34671560
- Journal of morphology 282:720-7322021Prenatal development in Lagostomus maximus (Rodentia, Chinchillidae): A unique case among eutherian mammals of physiological embryonic death.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFrancisco Acuña,Claudio G Barbeito,Enrique L Portiansky,María A Miglino,Mirta A FlaminiPubMed 33638264
- Archives of oral biology 122:1050262020Donor variation and sex hormone receptors in periodontal ligament cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnja Quast,Viktor Martian,Annegret Bohnsack,Sarah Batschkus,Philipp Meyer-Marcotty,Nicolai MiosgePubMed 33348207
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide
Constituents: 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human PGR aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P06401
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Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Chimpanzee | Predicted | Predicted |
| Dog | Predicted | Predicted |
| Gorilla | Predicted | Predicted |
| Orangutan | Predicted | Predicted |
| Rabbit | Predicted | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.5-1 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rabbit, Dog, Chimpanzee, Gorilla, Orangutan | Dilution info - | Notes - |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.1-0.5 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rabbit, Dog, Chimpanzee, Gorilla, Orangutan | Dilution info - | Notes - |
Associated Products
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Target data
Function
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.Isoform ALigand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.Isoform BTranscriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.Isoform 4Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Alternative names
Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, NR3C3, PGR
Recommended products
Rabbit Polyclonal Progesterone Receptor antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PGR aa 550 to C-terminus.
Alternative names
Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, NR3C3, PGR
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide
Constituents: 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human PGR aa 550 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link P06401
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The progesterone receptor (PR) also known as NR3C3 is a nuclear receptor that functions as a transcription factor in response to the hormone progesterone. This receptor has a mass of approximately 99 kDa and is expressed in tissues such as the reproductive organs including the uterus ovaries and mammary glands. It is also found in non-reproductive tissues like the brain and bone. The receptor has two main isoforms PR-A and PR-B which differ slightly in structure but have unique biological roles.
- Biological function summary
The progesterone receptor plays a significant role in regulating gene expression related to reproductive processes. PR is not part of a larger complex by itself but interacts with various coactivators and corepressors to modulate transcription. In the uterus and mammary glands PR mediates the effects of progesterone by promoting cell proliferation and preparing tissues for pregnancy. In other systems PR also links to various metabolic and immunological pathways influencing cell cycle progression and immune response.
- Pathways
Progesterone receptor activity is integrated within the reproductive hormone signaling pathways and the Wnt signaling pathway. The receptor interacts directly with key proteins such as estrogen receptor (ER) and steroid receptor coactivator (SRC) complexes which are pivotal in modulating response to hormonal signals. These interactions underline the essential role of PR in maintaining hormonal balance and regulating reproductive functions.
- Associated diseases and disorders
The progesterone receptor associates with breast cancer and endometriosis. Aberrant expression or mutations in PR can contribute to the development and progression of breast cancer often linked with the estrogen receptor's influence. In endometriosis PR's altered functionality affects cellular response to progesterone contributing to tissue growth outside the uterus. These conditions also involve interactions with proteins like BRCA1 in breast cancer highlighting how PR connects to broader cellular and pathological networks.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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4 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody - C-terminal (ab191138)
Immunohistochemical analysis of paraffin-embedded Human Intestinal Cancer Tissue labeling Progesterone Receptor with ab191138 at 1 μg/ml.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody - C-terminal (ab191138)
Immunohistochemical analysis of paraffin-embedded Human Mammary Cancer Tissue labeling Progesterone Receptor with ab191138 at 1 μg/ml.
Western blot - Anti-Progesterone Receptor antibody - C-terminal (ab191138)
All lanes: Western blot - Anti-Progesterone Receptor antibody - C-terminal (ab191138) at 0.1 µg/mL
All lanes: Human T-47D whole cell lysates. at 50 µg
SecondaryAll lanes: Goat anti-Rabbit IgG-HRP for 1.5 hours at room temperature at 1/10000 dilution
Performed under reducing conditions.
Predicted band size: 98 kDa
Observed band size: 90 kDa, 99 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Progesterone Receptor antibody - C-terminal (ab191138)
Immunohistochemical analysis of paraffin-embedded Human Lung Cancer Tissue labeling Progesterone Receptor with ab191138 at 1 μg/ml.
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