Rabbit Polyclonal Prokineticin 2/PK2 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 13 publications.
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- Arthritis research & therapy 25:2362023Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiye Yang,Youngnim Shin,Hwee-Jin Kim,Hyo-Eun Kim,Jang-Soo ChunPubMed 38057865
- Brain, behavior, and immunity 108:302-3082022Substance P and Prokineticin-2 are overexpressed in olfactory neurons and play differential roles in persons with persistent post-COVID-19 olfactory dysfunction.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTommaso Schirinzi,Roberta Lattanzi,Daniela Maftei,Piergiorgio Grillo,Henri Zenuni,Laura Boffa,Maria Albanese,Clara Simonetta,Roberta Bovenzi,Riccardo Maurizi,Laura Loccisano,Martina Vincenzi,Antonio Greco,Stefano Di Girolamo,Nicola B Mercuri,Francesco M Passali,Cinzia SeveriniPubMed 36549578
- Annals of neurology 93:196-2042022Olfactory Neuron Prokineticin-2 as a Potential Target in Parkinson's Disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTommaso Schirinzi,Daniela Maftei,Francesco M Passali,Piergiorgio Grillo,Henri Zenuni,Davide Mascioli,Riccardo Maurizi,Laura Loccisano,Martina Vincenzi,Anna Maria Rinaldi,Massimo Ralli,Stefano Di Girolamo,Alessandro Stefani,Roberta Lattanzi,Cinzia Severini,Nicola B MercuriPubMed 36218142
- Reproductive biology and endocrinology : RB&E 20:762022Increased expression of prokineticin 2 and its receptor in endometrium of recurrent implantation failure patients decreased the expression of MMP9 important for decidualization.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJun Zhai,Linna Ma,Ziyin Chang,Ting YuPubMed 35501804
- Scientific reports 11:183992021Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKentaro Noda,Bianca Dufner,Haruyasu Ito,Ken Yoshida,Gianfranco Balboni,Rainer H StraubPubMed 34526577
- The EMBO journal 40:e1086142021Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEmma L Morris,Andrew P Patton,Johanna E Chesham,Alastair Crisp,Antony Adamson,Michael H HastingsPubMed 34487375
- Nature communications 12:42202021Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhongyuan Bao,Yinlong Liu,Binglin Chen,Zong Miao,Yiming Tu,Chong Li,Honglu Chao,Yangfan Ye,Xiupeng Xu,Guangchi Sun,Pengzhan Zhao,Ning Liu,Yan Liu,Xiaoming Wang,Sin Man Lam,Valerian E Kagan,Hülya Bayır,Jing JiPubMed 34244497
- Oxidative medicine and cellular longevity 2020:70758362020Methane Ameliorates Lipopolysaccharide-Induced Acute Orchitis by Anti-inflammatory, Antioxidative, and Antiapoptotic Effects via Regulation of the PK2/PKR1 Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChao Huang,Wenbo Zhang,Aijun Sun,Xi Zhang,Jinping Guo,Ruijuan Ji,Liang Qiao,Xuejun Sun,Dongbao ZhaoPubMed 32922653
- Bioscience reports 40:2020Dexmedetomidine alleviated neuropathic pain in dorsal root ganglion neurons by inhibition of anaerobic glycolysis activity and enhancement of ROS tolerance.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPeibin Liu,Tufeng Chen,Fang Tan,Jingling Tian,Lei Zheng,Yingqing Deng,Jiaxin Chen,Xinjin ChiPubMed 32285913
- Cells 8:2019Involvement of the Chemokine Prokineticin-2 (PROK2) in Alzheimer's Disease: From Animal Models to the Human Pathology.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRoberta Lattanzi,Daniela Maftei,Carla Petrella,Massimo Pieri,Giulia Sancesario,Tommaso Schirinzi,Sergio Bernardini,Christian Barbato,Massimo Ralli,Antonio Greco,Roberta Possenti,Giuseppe Sancesario,Cinzia SeveriniPubMed 31766244
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Constituents: Whole serum
- Form
Liquid
- Clonality
Polyclonal
Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Predicted |
| Mouse | Tested |
| Rat | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/100.00000 - 1/1000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Human, Rat | Dilution info - | Notes - |
Target data
Function
May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.
Alternative names
BV8, PROK2, Prokineticin-2, PK2, Protein Bv8 homolog
Recommended products
Rabbit Polyclonal Prokineticin 2/PK2 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 13 publications.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
Constituents: Whole serum
- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- The exact immunogen used to generate this antibody is proprietary information.
- Purity
Whole antiserum
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Prokineticin 2 also known as PK2 is a peptide hormone weighing approximately 10 kDa. PK2 is largely expressed in the suprachiasmatic nucleus and various other brain regions including peripheral tissues such as the testes and intestines. Mechanically PK2 interacts with the prokineticin receptors PKR1 and PKR2 to produce its effects. It binds these G protein-coupled receptors (GPCRs) and activates intracellular signaling cascades influencing many physiological processes.
- Biological function summary
PK2 plays significant roles in various regulatory functions in the body. It partakes in the circadian rhythm regulation reproductive functions and the modulation of pain perception. While PK2 functions independently it often interacts with other proteins in intricate signaling networks to achieve its biological effects. Its expression is responsive to environmental light and is intricately tied to the body’s clock system.
- Pathways
PK2 is an essential component of the circadian rhythm and reproductive systems. In the circadian system PK2 acts within the light-entrainment pathway synchronizing biological rhythms. PK2 connects with proteins like BMAL1 and CLOCK forming links through feedback loops that are important for rhythm generation. In reproductive pathways PK2 influences gonadotropin-releasing hormone (GnRH) release contributing to fertility regulation.
- Associated diseases and disorders
PK2 involvement becomes notable in conditions like infertility and sleep disorders. PK2 dysregulation can contribute to abnormal circadian signals which may impact sleep patterns. Additionally the PK2-GnRH axis can affect reproductive health linking PK2 to fertility issues. The protein’s connection with other proteins like PKR1 during these pathological conditions underlines its potential as a target for therapeutic intervention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prokineticin 2/PK2 antibody (ab76747)
A: ab76747 staining Prokinectin 2 in Mouse testis by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
B: Negative control treated with preimmune serum.
Both sections counterstained with haematoxylin.
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