AB76747

Anti-Prokineticin 2/PK2 antibody

Name: Anti-Prokineticin 2/PK2 antibody (ab76747) | Abcam
Brand: Abcam Limited
SKU: AB76747
Price: 430 USD
Availability: InStock

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(15 Publications)

Rabbit Polyclonal Prokineticin 2/PK2 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 15 publications.

View Alternative Names

BV8, PROK2, Prokineticin-2, PK2, Protein Bv8 homolog

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prokineticin 2/PK2 antibody (AB76747)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prokineticin 2/PK2 antibody (AB76747)

A : ab76747 staining Prokinectin 2 in Mouse testis by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).
B : Negative control treated with preimmune serum.
Both sections counterstained with haematoxylin.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purity

Whole antiserum

Storage buffer

Constituents: Whole serum

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prokineticin 2 also known as PK2 is a peptide hormone weighing approximately 10 kDa. PK2 is largely expressed in the suprachiasmatic nucleus and various other brain regions including peripheral tissues such as the testes and intestines. Mechanically PK2 interacts with the prokineticin receptors PKR1 and PKR2 to produce its effects. It binds these G protein-coupled receptors (GPCRs) and activates intracellular signaling cascades influencing many physiological processes.

Biological function summary

PK2 plays significant roles in various regulatory functions in the body. It partakes in the circadian rhythm regulation reproductive functions and the modulation of pain perception. While PK2 functions independently it often interacts with other proteins in intricate signaling networks to achieve its biological effects. Its expression is responsive to environmental light and is intricately tied to the body’s clock system.

Pathways

PK2 is an essential component of the circadian rhythm and reproductive systems. In the circadian system PK2 acts within the light-entrainment pathway synchronizing biological rhythms. PK2 connects with proteins like BMAL1 and CLOCK forming links through feedback loops that are important for rhythm generation. In reproductive pathways PK2 influences gonadotropin-releasing hormone (GnRH) release contributing to fertility regulation.

PK2 involvement becomes notable in conditions like infertility and sleep disorders. PK2 dysregulation can contribute to abnormal circadian signals which may impact sleep patterns. Additionally the PK2-GnRH axis can affect reproductive health linking PK2 to fertility issues. The protein’s connection with other proteins like PKR1 during these pathological conditions underlines its potential as a target for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle.

See full target information PROK2

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Publications (15)

Recent publications for all applications. Explore the full list and refine your search

Movement disorders : official journal of the Movement Disorder Society 39:2091-2097 PubMed39051733

2024

Prokineticin-2 Is Highly Expressed in Colonic Mucosa of Early Parkinson's Disease Patients.

Applications

Unspecified application

Species

Unspecified reactive species

Gabriele Bellini,Francesco Rettura,Giovanni Palermo,Chiara Ippolito,Cristina Segnani,Clarissa Pierucci,Lorenzo Fontanelli,Daniela Frosini,Vincenzo Nardini,Christian Lambiase,Nunzia Bernardini,Carolina Pellegrini,Roberto Ceravolo

Arthritis research & therapy 25:236 PubMed38057865

2023

Prokineticin 2 is a catabolic regulator of osteoarthritic cartilage destruction in mouse.

Applications

Unspecified application

Species

Unspecified reactive species

Jiye Yang,Youngnim Shin,Hwee-Jin Kim,Hyo-Eun Kim,Jang-Soo Chun

Brain, behavior, and immunity 108:302-308 PubMed36549578

2022

Substance P and Prokineticin-2 are overexpressed in olfactory neurons and play differential roles in persons with persistent post-COVID-19 olfactory dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Tommaso Schirinzi,Roberta Lattanzi,Daniela Maftei,Piergiorgio Grillo,Henri Zenuni,Laura Boffa,Maria Albanese,Clara Simonetta,Roberta Bovenzi,Riccardo Maurizi,Laura Loccisano,Martina Vincenzi,Antonio Greco,Stefano Di Girolamo,Nicola B Mercuri,Francesco M Passali,Cinzia Severini

Nature communications 13:7703 PubMed36513690

2022

Locally organised and activated Fth1 neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Kun Wang,Muyun Wang,Ximing Liao,Shaoyong Gao,Jing Hua,Xiaodong Wu,Qian Guo,Wujian Xu,Jiaxing Sun,Yanan He,Qiang Li,Wei Gao

Annals of neurology 93:196-204 PubMed36218142

2022

Olfactory Neuron Prokineticin-2 as a Potential Target in Parkinson's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Tommaso Schirinzi,Daniela Maftei,Francesco M Passali,Piergiorgio Grillo,Henri Zenuni,Davide Mascioli,Riccardo Maurizi,Laura Loccisano,Martina Vincenzi,Anna Maria Rinaldi,Massimo Ralli,Stefano Di Girolamo,Alessandro Stefani,Roberta Lattanzi,Cinzia Severini,Nicola B Mercuri

Reproductive biology and endocrinology : RB&E 20:76 PubMed35501804

2022

Increased expression of prokineticin 2 and its receptor in endometrium of recurrent implantation failure patients decreased the expression of MMP9 important for decidualization.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Zhai,Linna Ma,Ziyin Chang,Ting Yu

Scientific reports 11:18399 PubMed34526577

2021

Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Kentaro Noda,Bianca Dufner,Haruyasu Ito,Ken Yoshida,Gianfranco Balboni,Rainer H Straub

The EMBO journal 40:e108614 PubMed34487375

2021

Single-cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin-driven circadian network.

Applications

Unspecified application

Species

Unspecified reactive species

Emma L Morris,Andrew P Patton,Johanna E Chesham,Alastair Crisp,Antony Adamson,Michael H Hastings

Nature communications 12:4220 PubMed34244497

2021

Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongyuan Bao,Yinlong Liu,Binglin Chen,Zong Miao,Yiming Tu,Chong Li,Honglu Chao,Yangfan Ye,Xiupeng Xu,Guangchi Sun,Pengzhan Zhao,Ning Liu,Yan Liu,Xiaoming Wang,Sin Man Lam,Valerian E Kagan,Hülya Bayır,Jing Ji

Oxidative medicine and cellular longevity 2020:7075836 PubMed32922653

2020

Methane Ameliorates Lipopolysaccharide-Induced Acute Orchitis by Anti-inflammatory, Antioxidative, and Antiapoptotic Effects via Regulation of the PK2/PKR1 Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Huang,Wenbo Zhang,Aijun Sun,Xi Zhang,Jinping Guo,Ruijuan Ji,Liang Qiao,Xuejun Sun,Dongbao Zhao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Prokineticin 2/PK2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prokineticin 2/PK2 antibody (AB76747)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purity

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (15)

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Primary Antibodies

Primary Antibodies

Primary Antibodies

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