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AB42805

Anti-PROKR2 antibody - Membrane Vesicle Marker

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(2 Publications)

Rabbit Polyclonal PROKR2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PROKR2.

View Alternative Names

GPR73L1, PKR2, PROKR2, Prokineticin receptor 2, PK-R2, G-protein coupled receptor 73-like 1, G-protein coupled receptor I5E, GPR73b, GPRg2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PROKR2 antibody - Membrane Vesicle Marker (AB42805)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PROKR2 antibody - Membrane Vesicle Marker (AB42805)

ab42805 staining PROKR2 in umbilical cord (top) and placental villi (bottom) sections by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). On the right are negative controls

Ho : Hofbauer cells; Ec : Endothelial cells; Bv : Blood vessels.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PROKR2. The exact immunogen used to generate this antibody is proprietary information.

Q8NFJ6

Specificity

This antibody reacts specifically with human PROKR2.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

PROKR2 also known as the Prokineticin Receptor 2 is a G protein-coupled receptor with a molecular weight of approximately 43 kDa. It binds to prokineticins which are small proteins involved in various biological processes. PROKR2 is expressed prominently in the central nervous system particularly in the hypothalamus and also in peripheral tissues such as the testis and the pituitary gland. The receptor when activated by its ligand facilitates intracellular signaling through downstream effectors.
Biological function summary

This receptor plays an important role in the regulation of circadian rhythm and reproductive functions. PROKR2 forms part of a signaling complex that influences the release of gonadotropin-releasing hormone. It partners with prokineticin ligands to mediate its effects orchestrating processes like sleep-wake cycles and olfactory bulb function. Its activity is important in maintaining normal physiological functions related to these processes.

Pathways

PROKR2 is deeply integrated into the hypothalamic-pituitary-gonadal (HPG) axis pathway influencing reproductive hormone release. Another important pathway is the circadian rhythm pathway where it links with proteins such as CLOCK and BMAL1. These pathways are essential for the daily regulation of biological rhythms and reproductive health aligning with environmental cues like light and darkness.

PROKR2 has associations with Kallmann syndrome a condition characterized by anosmia and hypogonadotropic hypogonadism. The receptor's abnormal expression or function can lead to impaired gonadal development. Another disorder related to PROKR2 is obesity where its signaling pathways intersect with leptin’s activity affecting body weight regulation. Understanding these connections is essential for developing therapeutic interventions in related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.
See full target information PROKR2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

American journal of translational research 12:5741-5751 PubMed33042453

2020

Tubal ectopic pregnancy occurrence is associated with high expressions of prokineticin receptors and aberrant secretion of inflammatory cytokines.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Ma,Zaiyi Li,Sujuan Xi,Quan Guo,Panlin Zhao,Weihao Li,Jing Ai,Xiaoxuan Chen

Cardiovascular research 81:28-37 PubMed18806277

2008

Transgenic myocardial overexpression of prokineticin receptor-2 (GPR73b) induces hypertrophy and capillary vessel leakage.

Applications

Unspecified application

Species

Unspecified reactive species

Kyoji Urayama,Deniz B Dedeoglu,Célia Guilini,Stefan Frantz,Georg Ertl,Nadia Messaddeq,Canan G Nebigil
View all publications
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Product promise

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