Rabbit Polyclonal PROKR2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PROKR2.
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- Cardiovascular research 81:28-372008Transgenic myocardial overexpression of prokineticin receptor-2 (GPR73b) induces hypertrophy and capillary vessel leakage.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKyoji Urayama,Deniz B Dedeoglu,Célia Guilini,Stefan Frantz,Georg Ertl,Nadia Messaddeq,Canan G NebigilPubMed 18806277
Key facts
- Host species
- Rabbit
- Storage buffer
Constituents: Whole serum
- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human PROKR2. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NFJ6
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50 | Notes - |
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1 product for Alternative Product
Target data
Function
Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.
Alternative names
GPR73L1, PKR2, PROKR2, Prokineticin receptor 2, PK-R2, G-protein coupled receptor 73-like 1, G-protein coupled receptor I5E, GPR73b, GPRg2
Recommended products
Rabbit Polyclonal PROKR2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human PROKR2.
Key facts
- Host species
- Rabbit
- Storage buffer
Constituents: Whole serum
- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human PROKR2. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NFJ6
- Purity
- Whole antiserum
- Specificity
This antibody reacts specifically with human PROKR2.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
PROKR2 also known as the Prokineticin Receptor 2 is a G protein-coupled receptor with a molecular weight of approximately 43 kDa. It binds to prokineticins which are small proteins involved in various biological processes. PROKR2 is expressed prominently in the central nervous system particularly in the hypothalamus and also in peripheral tissues such as the testis and the pituitary gland. The receptor when activated by its ligand facilitates intracellular signaling through downstream effectors.
- Biological function summary
This receptor plays an important role in the regulation of circadian rhythm and reproductive functions. PROKR2 forms part of a signaling complex that influences the release of gonadotropin-releasing hormone. It partners with prokineticin ligands to mediate its effects orchestrating processes like sleep-wake cycles and olfactory bulb function. Its activity is important in maintaining normal physiological functions related to these processes.
- Pathways
PROKR2 is deeply integrated into the hypothalamic-pituitary-gonadal (HPG) axis pathway influencing reproductive hormone release. Another important pathway is the circadian rhythm pathway where it links with proteins such as CLOCK and BMAL1. These pathways are essential for the daily regulation of biological rhythms and reproductive health aligning with environmental cues like light and darkness.
- Associated diseases and disorders
PROKR2 has associations with Kallmann syndrome a condition characterized by anosmia and hypogonadotropic hypogonadism. The receptor's abnormal expression or function can lead to impaired gonadal development. Another disorder related to PROKR2 is obesity where its signaling pathways intersect with leptin’s activity affecting body weight regulation. Understanding these connections is essential for developing therapeutic interventions in related disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PROKR2 antibody (ab42805)
ab42805 staining PROKR2 in umbilical cord (top) and placental villi (bottom) sections by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). On the right are negative controls
Ho: Hofbauer cells; Ec: Endothelial cells; Bv: Blood vessels.
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