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AB119999

Anti-Prol1 antibody

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(4 Publications)

Goat Polyclonal Prol1 antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 4 publications.
1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prol1 antibody (AB119999)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prol1 antibody (AB119999)

ab119999 (2.9 μg/ml) staining of cells in the submandibular salivery gland (SMG), but not in the sublingual salivery gland (SLG) in mouse.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P

applications

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab119999 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: 99% Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prol1 also known as Prolargin or PRELP represents a small leucine-rich proteoglycan with an approximate mass around 40 kDa. It is largely expressed in connective tissues such as cartilage and skin. Prol1 helps in maintaining the structural integrity of the extracellular matrix by interacting with collagen and its expression levels can vary across different types of connective tissues. It's notable for binding with extracellular matrix components playing a role in tissue organization.
Biological function summary

Prol1 contributes significant roles in connective tissue development and maintenance. It's not typically part of larger protein complexes but it binds directly to structural proteins like collagen and other matrix molecules. Prol1 also shows activity in modulating cell adhesion processes impacting how cells interact with the surrounding matrix. This capacity allows it to influence tissue repair mechanisms and homeostasis.

Pathways

Prol1 interacts prominently in extracellular matrix organization pathways and the collagen fibril organization pathway. It closely associates with proteins like decorin and biglycan which are also part of the small leucine-rich proteoglycan family. Through these pathways Prol1 ensures proper collagen alignment and structural integrity affecting matrix homeostasis and tissue resilience.

Prol1 relates to conditions such as osteoarthritis and spondyloepimetaphyseal dysplasia. The disruption or mutation of Prol1 can lead to abnormal collagen deposition which affects joint functionality and cartilage integrity. Additionally interactions with proteins like collagen II have been observed in such conditions indicating Prol1's role in disease mechanisms. Understanding Prol1's impact on these disorders helps in developing targeted therapeutic approaches.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Prol1
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Andrology 11:591-610 PubMed36374586

2022

Cytoskeletal protein SPTA1 mediating the decrease in erectile function induced by high-fat diet via Hippo signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Chen,Lei Wang,Zhan-Sen Huang,Jia-Xin Feng,Shi-Xiong Li,Zi-Jun Du,Ze-Bo Zhang,Jing Liu,Jian Yang,Zhi-Ming Hu,Zhi-Lin Wang,Jun Chen

PloS one 16:e0245607 PubMed33465144

2021

Bmi-1 regulates mucin levels and mucin O-glycosylation in the submandibular gland of mice.

Applications

Unspecified application

Species

Unspecified reactive species

Akihiko Kameyama,Risa Nishijima,Kimi Yamakoshi

Nature communications 11:991 PubMed32080185

2020

Tracing tumorigenesis in a solid tumor model at single-cell resolution.

Applications

Unspecified application

Species

Unspecified reactive species

Samantha D Praktiknjo,Benedikt Obermayer,Qionghua Zhu,Liang Fang,Haiyue Liu,Hazel Quinn,Marlon Stoeckius,Christine Kocks,Walter Birchmeier,Nikolaus Rajewsky

Biochimica et biophysica acta. Proteins and proteomics 1867:76-81 PubMed29753090

2018

A rapid separation and characterization of mucins from mouse submandibular glands by supported molecular matrix electrophoresis.

Applications

WB

Species

Unspecified reactive species

Akihiko Kameyama,Kimi Yamakoshi,Atsushi Watanabe
View all publications
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