AB64377

Anti-Prolactin/PRL antibody

Name: Anti-Prolactin/PRL antibody (ab64377) | Abcam
Brand: Abcam Limited
SKU: AB64377
Price: 515 USD
Availability: InStock

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(6 Publications)

Anti-Prolactin/PRL antibody (ab64377) is a rabbit polyclonal antibody detecting Prolactin/PRL in IHC-P. Suitable for Human.

- Trusted since 2008

View Alternative Names

Prolactin, PRL, Decidual prolactin, GHA1, Growth hormone A1, Lactogenic Hormone, Luteotropic Hormone, Mammotropin, Prolactin, Prolactin precursor

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prolactin/PRL antibody (AB64377)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prolactin/PRL antibody (AB64377)

ab64377, at a dilution of 1/200, staining Prolactin/PRL in formalin fixed, paraffin embedded human pituitary gland tissue by Immunohistochemistry.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200", "IHCP-species-notes": "<p></p>" } } }

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Product details

What is this antibody validated in?
Anti-Prolactin/PRL antibody (ab64377) is a rabbit polyclonal antibody and is validated for use in Immunohistochemistry (IHC-P) in Human samples.

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.6 Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prolactin (PRL) also known as mammotropin is a peptide hormone with a molecular mass of approximately 23 kDa. PRL is primarily expressed in the anterior pituitary gland but can also be found in other tissues such as the mammary glands brain and immune system. PRL plays an important role in lactation stimulating milk production in mammals. The PRL protein functions by binding to the prolactin receptor a member of the cytokine receptor family initiating signal transduction pathways.

Biological function summary

PRL influences a variety of physiological processes including reproduction metabolism and osmoregulation. It acts as a single entity rather than part of a larger protein complex affecting development and growth through its regulatory activities. In addition to lactation PRL also plays roles in the immune system cell proliferation and the production of surfactant in the lungs.

Pathways

Prolactin is deeply involved in the JAK-STAT signaling pathway and the MAPK/ERK pathway which are pivotal for transmitting signals from the prolactin receptor to the nucleus. Through these pathways PRL interacts with proteins like Janus kinase (JAK) and Signal Transducer and Activator of Transcription (STAT) proteins facilitating its wide range of biological effects. This interplay helps regulate gene expression critical for various physiological conditions.

PRL is linked to conditions such as hyperprolactinemia and prolactinoma. Hyperprolactinemia characterized by elevated levels of prolactin in the blood can lead to symptoms such as galactorrhea and infertility. In the context of prolactinoma an adenoma of the pituitary gland PRL's overproduction is common. These disorders often relate to proteins like dopamine which typically acts to inhibit PRL secretion from the pituitary gland and any disruption in this regulation can result in the aforementioned conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Prolactin acts primarily on the mammary gland by promoting lactation.

See full target information PRL

Additional targets

Prolactin/PRL

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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

The Journal of clinical endocrinology and metabolism 107:2318-2328 PubMed35485764

2022

Genome-wide DNA Methylation Differences in Nonfunctioning Pituitary Adenomas With and Without Postsurgical Progression.

Applications

Unspecified application

Species

Unspecified reactive species

Tobias Hallén,Gudmundur Johannsson,Rahil Dahlén,Camilla A M Glad,Charlotte Örndal,Angelica Engvall,Helena Carén,Thomas Skoglund,Daniel S Olsson

Aging 13:1422-1439 PubMed33472171

2020

Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Yiyuan Chen,Hua Gao,Qian Liu,Weiyan Xie,Bin Li,Sen Cheng,Jing Guo,Qiuyue Fang,Haibo Zhu,Zhuang Wang,Jichao Wang,Chuzhong Li,Yazhuo Zhang

Human & experimental toxicology 38:1244-1253 PubMed31319705

2019

Evaluation of screening for drug use using postmortem prolactin levels in serum and cerebrospinal fluid.

Applications

Unspecified application

Species

Unspecified reactive species

N Tani,T Ikeda,Y Aoki,A Shida,S Oritani,T Ishikawa

PloS one 13:e0198673 PubMed29949606

2018

Prolactin selectively transported to cerebrospinal fluid from blood under hypoxic/ischemic conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Naoto Tani,Tomoya Ikeda,Miho Watanabe,Junko Toyomura,Akihiro Ohyama,Takaki Ishikawa

Experimental and therapeutic medicine 14:5949-5955 PubMed29285144

2017

Icaritin inhibits decidualization of endometrial stromal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Aiwen Le,Zhong Hai Wang,Xiao Yun Dai,Tian Hui Xiao,Rong Zhuo,Baozhen Zhang,Zhonglin Xiao,Xiujun Fan

PLoS biology 11:e1001542 PubMed23630454

2013

PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.

Applications

IHC-P

Species

Mouse

Birgitte Holst,Kenneth L Madsen,Anna M Jansen,Chunyu Jin,Mattias Rickhag,Viktor K Lund,Morten Jensen,Vikram Bhatia,Gunnar Sørensen,Andreas N Madsen,Zhichao Xue,Siri K Møller,David Woldbye,Klaus Qvortrup,Richard Huganir,Dimitrios Stamou,Ole Kjærulff,Ulrik Gether

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Prolactin/PRL antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prolactin/PRL antibody (AB64377)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Additional targets

Publications (6)

Product promise