AB11301

Anti-Prolactin/PRL antibody [INN-hPRL-1]

Name: Anti-Prolactin/PRL antibody [INN-hPRL-1] (ab11301) | Abcam
Brand: Abcam Limited
SKU: AB11301

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(5 Publications)

Mouse Monoclonal Prolactin/PRL antibody. Suitable for IHC-P and reacts with Human samples. Cited in 5 publications.

View Alternative Names

Prolactin, PRL, Decidual prolactin, GHA1, Growth hormone A1, Lactogenic Hormone, Luteotropic Hormone, Mammotropin, Prolactin, Prolactin precursor

1 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prolactin/PRL antibody [INN-hPRL-1] (AB11301)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prolactin/PRL antibody [INN-hPRL-1] (AB11301)

ab11301 staining Prolactin/PRL in Human pituitary tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Heat-mediated antigen retrieval (EDTA pH 8.0) was used.

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

INN-hPRL-1

Isotype

IgG1

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Epitope

Epitope c.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." } } }

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Product details

This product should be stored undiluted. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

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Properties and storage information

Form

Liquid

Purification technique

Ion exchange chromatography

Storage buffer

Preservative: 0.09% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prolactin (PRL) also known as mammotropin is a peptide hormone with a molecular mass of approximately 23 kDa. PRL is primarily expressed in the anterior pituitary gland but can also be found in other tissues such as the mammary glands brain and immune system. PRL plays an important role in lactation stimulating milk production in mammals. The PRL protein functions by binding to the prolactin receptor a member of the cytokine receptor family initiating signal transduction pathways.

Biological function summary

PRL influences a variety of physiological processes including reproduction metabolism and osmoregulation. It acts as a single entity rather than part of a larger protein complex affecting development and growth through its regulatory activities. In addition to lactation PRL also plays roles in the immune system cell proliferation and the production of surfactant in the lungs.

Pathways

Prolactin is deeply involved in the JAK-STAT signaling pathway and the MAPK/ERK pathway which are pivotal for transmitting signals from the prolactin receptor to the nucleus. Through these pathways PRL interacts with proteins like Janus kinase (JAK) and Signal Transducer and Activator of Transcription (STAT) proteins facilitating its wide range of biological effects. This interplay helps regulate gene expression critical for various physiological conditions.

PRL is linked to conditions such as hyperprolactinemia and prolactinoma. Hyperprolactinemia characterized by elevated levels of prolactin in the blood can lead to symptoms such as galactorrhea and infertility. In the context of prolactinoma an adenoma of the pituitary gland PRL's overproduction is common. These disorders often relate to proteins like dopamine which typically acts to inhibit PRL secretion from the pituitary gland and any disruption in this regulation can result in the aforementioned conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Prolactin acts primarily on the mammary gland by promoting lactation.

See full target information PRL

Additional targets

Prolactin/PRL

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Acta neuropathologica 147:16 PubMed38228887

2024

Pituitary neuroendocrine tumors with PIT1/SF1 co-expression show distinct clinicopathological and molecular features.

Applications

Unspecified application

Species

Unspecified reactive species

Matthias Dottermusch,Alice Ryba,Franz L Ricklefs,Jörg Flitsch,Simone Schmid,Markus Glatzel,Wolfgang Saeger,Julia E Neumann,Ulrich Schüller

Scientific reports 13:19325 PubMed37935840

2023

Plasma level of omentin-1, its expression, and its regulation by gonadotropin-releasing hormone and gonadotropins in porcine anterior pituitary cells.

Applications

Unspecified application

Species

Unspecified reactive species

Natalia Respekta,Karolina Pich,Ewa Mlyczyńska,Kamil Dobrzyń,Christelle Ramé,Tadeusz Kamiński,Nina Smolińska,Joëlle Dupont,Agnieszka Rak

Scientific reports 13:18253 PubMed37880346

2023

Visfatin in the porcine pituitary gland: expression and regulation of secretion during the oestrous cycle and early pregnancy.

Applications

Unspecified application

Species

Unspecified reactive species

Karolina Szymanska,Ewa Zaobidna,Edyta Rytelewska,Ewa Mlyczynska,Patrycja Kurowska,Kamil Dobrzyn,Marta Kiezun,Barbara Kaminska,Nina Smolinska,Agnieszka Rak,Tadeusz Kaminski

mAbs 15:2254676 PubMed37698877

2023

Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders.

Applications

Unspecified application

Species

Unspecified reactive species

Stephanie Maciuba,Gregory D Bowden,Harrison J Stratton,Kazimierz Wisniewski,Claudio D Schteingart,Juan C Almagro,Philippe Valadon,Joshua Lowitz,Scott M Glaser,Grace Lee,Mahdi Dolatyari,Edita Navratilova,Frank Porreca,Pierre J M Rivière

Endocrine 76:228-236 PubMed35171439

2022

ACTH-secreting pituitary carcinoma with TP53, NF1, ATRX and PTEN mutations Case report and review of the literature.

Applications

Unspecified application

Species

Unspecified reactive species

Piotr Sumislawski,Roman Rotermund,Silke Klose,Anne Lautenbach,Annika K Wefers,Celina Soltwedel,Behnam Mohammadi,Frank Jacobsen,Christian Mawrin,Jörg Flitsch,Wolfgang Saeger

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Prolactin/PRL antibody [INN-hPRL-1]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prolactin/PRL antibody [INN-hPRL-1] (AB11301)

Key facts

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Epitope

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Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Additional targets

Publications (5)

Product promise