Rabbit Polyclonal Prominin 2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PROM2 conjugated to Keyhole Limpet Haemocyanin.
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Publications
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- Radiology and oncology 57:325-3362023Prominin 2 decreases cisplatin sensitivity in non-small cell lung cancer and is modulated by CTCC binding factor.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiyang Tang,Dejun Shu,Zhimin Fang,Gaolan YangPubMed 37665741
- Andrology 2:559-712014Effects of the oestrogen receptor antagonist Fulvestrant on expression of genes that affect organization of the epididymal epithelium.Applications:Unspecified applicationReactive species:Unspecified reactive speciesM F N Pereira,S A F Fernandes,A R Nascimento,E R Siu,R A Hess,C A Oliveira,C S Porto,M F M LazariPubMed 24782439
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human PROM2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q8N271
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 15.00000-20.00000 µg/mL | Notes - |
Associated Products
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1 product for Alternative Product
Target data
Alternative names
PROML2, UNQ2521/PRO6014, PROM2, Prominin-2, PROM-2, Prominin-like protein 2, hPROML2
Recommended products
Rabbit Polyclonal Prominin 2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PROM2 conjugated to Keyhole Limpet Haemocyanin.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human PROM2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q8N271
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Prominin-2 also known as PROM2 is a transmembrane glycoprotein weighing approximately 124 kDa. It is part of the prominin family and is mainly expressed in epithelial cells of various tissues including the kidney pancreas and intestine. Mechanically Prominin-2 is involved in the organization of membrane protrusions due to its ability to bind to cholesterol. It localizes to plasma membrane sites and plays a role in maintaining cell morphology.
- Biological function summary
Prominin-2 participates in several processes involving cellular differentiation and maintenance. It does not form a part of any known complex but interacts with cellular membranes to influence lipid composition. Prominin-2 facilitates cellular processes like epithelial cell polarity and is implicated in maintaining stem cell populations. Its association with membrane structures is key to its function in these contexts.
- Pathways
Prominin-2 acts in cellular polarity and wound healing pathways. In the polarity pathway Prominin-2 associates with proteins like CDC42 essential for establishing asymmetry in cells. Within wound healing it interacts with the MAPK signaling pathway where its involvement affects cell migration and repair mechanisms. These pathways underline the role of Prominin-2 in maintaining epithelial integrity and repair.
- Associated diseases and disorders
Research links Prominin-2 to certain forms of cancer and retinal degeneration. In cancer Prominin-2 promotes tumorigenic potential by influencing cancer cell stemness and resistance to apoptosis. Connections to cancer-related proteins like CD133 highlight its role in tumor biology. In retinal degeneration alterations in Prominin-2 expression correlate with visual impairment possibly through disruptions in retinal epithelial cell structure.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prominin 2 antibody (ab118492)
ab118492 at 0.5 μg/ml staining Prominin 2 in Human Lung, Respiratory Epithelium by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prominin 2 antibody (ab118492)
ab118492 at 0.5 µg/ml staining Prominin 2 in Human Uterus by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
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