JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB118492

Anti-Prominin 2 antibody

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Polyclonal Prominin 2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PROM2 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

PROML2, UNQ2521/PRO6014, PROM2, Prominin-2, PROM-2, Prominin-like protein 2, hPROML2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prominin 2 antibody (AB118492)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prominin 2 antibody (AB118492)

ab118492 at 0.5 μg/ml staining Prominin 2 in Human Lung, Respiratory Epithelium by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prominin 2 antibody (AB118492)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Prominin 2 antibody (AB118492)

ab118492 at 0.5 µg/ml staining Prominin 2 in Human Uterus by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human PROM2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8N271

style
left-column

Alternative Products

Primary Antibodies

AB74997

Anti-Prominin 2 antibody

  • 5
  • 1

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
Primary Antibodies

AB121685

Anti-ZNF750 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF750 antibody (AB121685)

  • 0
  • 0
Primary Antibodies

AB216347

Anti-SNAIL antibody [EPR21043]

20ul selling size|KO Validated|RabMAb|Recombinant

Western blot - Anti-SNAIL antibody [EPR21043] (AB216347)

  • 1
  • 1
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "15-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prominin-2 also known as PROM2 is a transmembrane glycoprotein weighing approximately 124 kDa. It is part of the prominin family and is mainly expressed in epithelial cells of various tissues including the kidney pancreas and intestine. Mechanically Prominin-2 is involved in the organization of membrane protrusions due to its ability to bind to cholesterol. It localizes to plasma membrane sites and plays a role in maintaining cell morphology.
Biological function summary

Prominin-2 participates in several processes involving cellular differentiation and maintenance. It does not form a part of any known complex but interacts with cellular membranes to influence lipid composition. Prominin-2 facilitates cellular processes like epithelial cell polarity and is implicated in maintaining stem cell populations. Its association with membrane structures is key to its function in these contexts.

Pathways

Prominin-2 acts in cellular polarity and wound healing pathways. In the polarity pathway Prominin-2 associates with proteins like CDC42 essential for establishing asymmetry in cells. Within wound healing it interacts with the MAPK signaling pathway where its involvement affects cell migration and repair mechanisms. These pathways underline the role of Prominin-2 in maintaining epithelial integrity and repair.

Research links Prominin-2 to certain forms of cancer and retinal degeneration. In cancer Prominin-2 promotes tumorigenic potential by influencing cancer cell stemness and resistance to apoptosis. Connections to cancer-related proteins like CD133 highlight its role in tumor biology. In retinal degeneration alterations in Prominin-2 expression correlate with visual impairment possibly through disruptions in retinal epithelial cell structure.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

See full target information PROM2
style
left-column

Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Radiology and oncology 57:325-336 PubMed37665741

2023

Prominin 2 decreases cisplatin sensitivity in non-small cell lung cancer and is modulated by CTCC binding factor.

Applications

Unspecified application

Species

Unspecified reactive species

Jiyang Tang,Dejun Shu,Zhimin Fang,Gaolan Yang

Andrology 2:559-71 PubMed24782439

2014

Effects of the oestrogen receptor antagonist Fulvestrant on expression of genes that affect organization of the epididymal epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

M F N Pereira,S A F Fernandes,A R Nascimento,E R Siu,R A Hess,C A Oliveira,C S Porto,M F M Lazari
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com