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AB74997

Anti-Prominin 2 antibody

5

(1 Review)

|

(6 Publications )

Rabbit Polyclonal Prominin 2 antibody. Suitable for ELISA and reacts with Mouse, Rat, Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human PROM2 aa 300-350.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

ELISA

applications

Immunogen

Synthetic Peptide within Human PROM2 aa 300-350. The exact immunogen used to generate this antibody is proprietary information.

Q8N271

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Mouse": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Rat": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.02% Sodium azide
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Prominin-2 also known as PROM2 is a transmembrane glycoprotein weighing approximately 124 kDa. It is part of the prominin family and is mainly expressed in epithelial cells of various tissues including the kidney pancreas and intestine. Mechanically Prominin-2 is involved in the organization of membrane protrusions due to its ability to bind to cholesterol. It localizes to plasma membrane sites and plays a role in maintaining cell morphology.
Biological function summary

Prominin-2 participates in several processes involving cellular differentiation and maintenance. It does not form a part of any known complex but interacts with cellular membranes to influence lipid composition. Prominin-2 facilitates cellular processes like epithelial cell polarity and is implicated in maintaining stem cell populations. Its association with membrane structures is key to its function in these contexts.

Pathways

Prominin-2 acts in cellular polarity and wound healing pathways. In the polarity pathway Prominin-2 associates with proteins like CDC42 essential for establishing asymmetry in cells. Within wound healing it interacts with the MAPK signaling pathway where its involvement affects cell migration and repair mechanisms. These pathways underline the role of Prominin-2 in maintaining epithelial integrity and repair.

Research links Prominin-2 to certain forms of cancer and retinal degeneration. In cancer Prominin-2 promotes tumorigenic potential by influencing cancer cell stemness and resistance to apoptosis. Connections to cancer-related proteins like CD133 highlight its role in tumor biology. In retinal degeneration alterations in Prominin-2 expression correlate with visual impairment possibly through disruptions in retinal epithelial cell structure.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information PROM2

Alternative Names

PROML2, UNQ2521/PRO6014, PROM2, Prominin-2, PROM-2, Prominin-like protein 2, hPROML2
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Publications (6)

Recent publications for all applications. Explore the full list and refine your search

Stem cell research & therapy 16:340 PubMed40598356

2025

Prominin-2/FBXO22/BACH1 axis protects bone marrow mesenchymal stem cells against TBHP-induced ferroptosis and ameliorates intervertebral disc degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Yuzhu Xu,Lele Zhang,Mingliang Ji,Jun Lu

Stem cell research & therapy 16:213 PubMed40301995

2025

Targeting prominin-2/BACH1/GLS pathway to inhibit oxidative stress-induced ferroptosis of bone mesenchymal stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yuzhu Xu,Lele Zhang,Xuanfei Xu,Yuao Tao,Pengfei Xue,Yuntao Wang,Renjie Chai,Xiaotao Wu

CytoJournal 22:21 PubMed40134569

2025

Prominin 2 knockdown inhibits the growth, migration, and invasion of non-small cell lung cancer cells by repressing phosphatidylinositol 3 kinase/protein kinase B pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Biao He,Ze Chen,Liang Zhong,Xiaoyong Pang

Aging cell 23:e14204 PubMed38757782

2024

Identification of Prominin-2 as a new player of cardiomyocyte senescence in the aging heart.

Applications

Unspecified application

Species

Unspecified reactive species

D Maggiorani,Y Santin,K Formoso,E Drapé,H Martini,S Brun,G Cousin,O Lairez,F Lezoualc'h,A Parini,V Douin-Echinard,J Mialet-Perez

Radiology and oncology 57:325-336 PubMed37665741

2023

Prominin 2 decreases cisplatin sensitivity in non-small cell lung cancer and is modulated by CTCC binding factor.

Applications

Unspecified application

Species

Unspecified reactive species

Jiyang Tang,Dejun Shu,Zhimin Fang,Gaolan Yang

Andrology 2:559-71 PubMed24782439

2014

Effects of the oestrogen receptor antagonist Fulvestrant on expression of genes that affect organization of the epididymal epithelium.

Applications

Unspecified application

Species

Unspecified reactive species

M F N Pereira,S A F Fernandes,A R Nascimento,E R Siu,R A Hess,C A Oliveira,C S Porto,M F M Lazari
View all publications
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Product promise

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